#condensates — Public Fediverse posts

RNA chaperone Hfq assembles into #condensates in response to stress in #Ecoli, but what leads to Hfq’s #PhaseSeparation? This study shows that #polyphosphate scaffolds the formation of Hfq condensates, which then stabilize polyA transcripts critical for recovery @PLOSBiology https://plos.io/4tI0xby

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927

#autophagy #optineurin #condensates

"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."

#neuron #condensates #cellMembrane #membranePotential

Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG

`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`

https://www.nature.com/articles/s41477-024-01633-y

#meiosis

Regulation of viral biomolecular #condensates:
#Phosphorylation in the intrinsically disordered region #IDR of #adenovirus protein 52K modulates its liquid-like properties and function in viral packaging

Nicholas Grams, Matthew Charman, Matthew Weitzman and colleagues

https://www.embopress.org/doi/full/10.1038/s44318-023-00021-0

This is really cool- great to see #singlemolecule *molecular* scale behaviour inside #condensates: https://www.nature.com/articles/s41586-023-06329-5

Happy to share new collaborative work on #singlemolecule imaging of biomolecular #condensates. They're less uniform than they seem! With #PappulabWashU @TingtingWu #MattKingLab #MinaFaragSci #WashUengineers

"Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates"
https://doi.org/10.1101/2023.01.26.525727

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem