#condensates — Public Fediverse posts

Outstanding talk by Milos Filipovic at #h2s2026 !

#Redox regulation of #condensates !

#stressgranules #ROS #RSS #Cysteine #Cys

@[email protected] @[email protected] @[email protected]

RNA chaperone Hfq assembles into #condensates in response to stress in #Ecoli, but what leads to Hfq’s #PhaseSeparation? This study shows that #polyphosphate scaffolds the formation of Hfq condensates, which then stabilize polyA transcripts critical for recovery @PLOSBiology https://plos.io/4tI0xby

Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927

#autophagy #optineurin #condensates

"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."

#neuron #condensates #cellMembrane #membranePotential

PRPP amidotransferase (PPAT) is rate-limiting in purine synthesis. This study shows that PPAT forms intracellular #condensates in response to high purine demand via #PhaseSeparation (driven by TORC1-mediated macromolecular crowding of cytoplasm) @PLOSBiology https://plos.io/3Yw2VVb

Synthetic compartments 'turbocharge' #bacteria for faster #protein production.

#condensates #mRNA

https://phys.org/news/2025-02-synthetic-compartments-turbocharge-bacteria-faster.html

A new doctoral network supported by @MSCActions & UK Guarantee Scheme launches: "#Condensates at #Membrane Scaffolds-Integrated Systems as Synthetic Cell Compartments" (@ComeInCell). 17 #PhD positions open!
https://nachrichten.idw-online.de/2024/11/28/comeincell-launches-a-european-doctoral-network-to-train-the-next-generation-of-cell-scientists

Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG

Bit late posting this here: Out now on #biorxiv: our grad student Katie took a deep dive into how different #IDRs affect the behaviour of #CBP #condensates in the nucleus. https://www.biorxiv.org/content/10.1101/2024.06.04.597392v2

`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`

https://www.nature.com/articles/s41477-024-01633-y

#meiosis

Regulation of viral biomolecular #condensates:
#Phosphorylation in the intrinsically disordered region #IDR of #adenovirus protein 52K modulates its liquid-like properties and function in viral packaging

Nicholas Grams, Matthew Charman, Matthew Weitzman and colleagues

https://www.embopress.org/doi/full/10.1038/s44318-023-00021-0

Functionalization of #ribonucleoprotein #condensates with #microtubule motors provides new tools for re-directing RNA to centrosomes or the cell periphery

Audrey Cochard, Zoher Gueroui et al

https://www.embopress.org/doi/full/10.15252/embj.2023114106

This is really cool- great to see #singlemolecule *molecular* scale behaviour inside #condensates: https://www.nature.com/articles/s41586-023-06329-5

Chromatin-associated condensates dysregulation in mendelian disorders

Università di Trento

#EU-funded #PhD project to address the contribution of #chromatin #condensates to define of the #genome architecture and nuclear #mechanobiology

See the full job description on jobRxiv: https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensa...
https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensates-dysregulation-in-mendelian-disorders/?feed_id=47152

Scientists find link between #photosynthesis and 'fifth state of matter' (#BoseEinsteinCondensate)

"#Photosynthetic light harvesting is taking place in a system that is at room temperature and what's more, its structure is disordered—very unlike the pristine crystallized #materials and cold temperatures that you use to make #exciton #condensates."

https://phys.org/news/2023-05-scientists-link-photosynthesis-state.html

“A University of Chicago study found links at the atomic level between photosynthesis and #exciton #condensates—a strange state of physics that allows energy to flow frictionlessly through a material. The finding is scientifically intriguing and may suggest new ways to think about designing electronics”

#UChicago
#Photosynthesis
#BoseEinstein

https://news.uchicago.edu/story/scientists-find-link-between-photosynthesis-and-fifth-state-matter

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696

Postdoctoral Position in Biological Physics @ZwickerGroup

Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.

https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=38116

#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=38116

🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature

https://www.molgen.mpg.de/4600883/

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462

Postdoctoral Position in Biological Physics @ZwickerGroup

Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.

https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=36081

#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=36081

Happy to share new collaborative work on #singlemolecule imaging of biomolecular #condensates. They're less uniform than they seem! With #PappulabWashU @TingtingWu #MattKingLab #MinaFaragSci #WashUengineers

"Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates"
https://doi.org/10.1101/2023.01.26.525727

Ph.D. position in Biological Physics @ZwickerGroup

Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.

https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=35286

#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=35286

...they 'just' correlate. It could very well be that the formation of condensates is a consequence of the difference observed rather than the cause. It could very well be that #condensates are a byproduct, a passive result of physical-chemical properties of highly abundant non translated mRNAs and their interacting proteins, and don't have a function per se. This, I would argue, should be the working model, until proven wrong. The end. 5/5

Let me rant about #condensates a propos this commentary👇. IMHO it illustrates a lot of the things that are wrong in #biology. From the top we are told "researchers are trying to work out how these ubiquitous beads form and what they do" [the condensates]. I would argue the first question should be "do they do anything?", but biologists abandoned 'Ockham's razor' long ago. The most parsimonious explanation would be condensates have no function... 1/n

#CellBiology #CellBio
https://www.nature.com/articles/d41586-022-03477-y

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem