#condensates — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #condensates, aggregated by home.social.
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RNA chaperone Hfq assembles into #condensates in response to stress in #Ecoli, but what leads to Hfq’s #PhaseSeparation? This study shows that #polyphosphate scaffolds the formation of Hfq condensates, which then stabilize polyA transcripts critical for recovery @PLOSBiology https://plos.io/4tI0xby
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Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates
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Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates
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Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates
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Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates
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Today I gave a short talk at the #EMBO workshop on Intracellular and organelle mechanobiology. I’m grateful to have been able to share my postdoc project and for the questions/comments! The whole workshop has been super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (1/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."
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"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."
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"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."
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"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."
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"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."
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PRPP amidotransferase (PPAT) is rate-limiting in purine synthesis. This study shows that PPAT forms intracellular #condensates in response to high purine demand via #PhaseSeparation (driven by TORC1-mediated macromolecular crowding of cytoplasm) @PLOSBiology https://plos.io/3Yw2VVb
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Synthetic compartments 'turbocharge' #bacteria for faster #protein production.
https://phys.org/news/2025-02-synthetic-compartments-turbocharge-bacteria-faster.html
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A new doctoral network supported by @MSCActions & UK Guarantee Scheme launches: "#Condensates at #Membrane Scaffolds-Integrated Systems as Synthetic Cell Compartments" (@ComeInCell). 17 #PhD positions open!
https://nachrichten.idw-online.de/2024/11/28/comeincell-launches-a-european-doctoral-network-to-train-the-next-generation-of-cell-scientists -
Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG
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Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG
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Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG
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Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG
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Condensates in Wnt/beta-catenin signaling: this study shows that formation of #BetaCatenin biomolecular #condensates that include the TF TCF/LEF1 is required for transcriptional activation of #Wnt target genes #PLOSBiology https://plos.io/3XU8qgG
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Bit late posting this here: Out now on #biorxiv: our grad student Katie took a deep dive into how different #IDRs affect the behaviour of #CBP #condensates in the nucleus. https://www.biorxiv.org/content/10.1101/2024.06.04.597392v2
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`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`
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Regulation of viral biomolecular #condensates:
#Phosphorylation in the intrinsically disordered region #IDR of #adenovirus protein 52K modulates its liquid-like properties and function in viral packagingNicholas Grams, Matthew Charman, Matthew Weitzman and colleagues
https://www.embopress.org/doi/full/10.1038/s44318-023-00021-0
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Functionalization of #ribonucleoprotein #condensates with #microtubule motors provides new tools for re-directing RNA to centrosomes or the cell periphery
Audrey Cochard, Zoher Gueroui et al
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This is really cool- great to see #singlemolecule *molecular* scale behaviour inside #condensates: https://www.nature.com/articles/s41586-023-06329-5
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Chromatin-associated condensates dysregulation in mendelian disorders
Università di Trento
#EU-funded #PhD project to address the contribution of #chromatin #condensates to define of the #genome architecture and nuclear #mechanobiology
See the full job description on jobRxiv: https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensa...
https://jobrxiv.org/job/universita-di-trento-27778-chromatin-associated-condensates-dysregulation-in-mendelian-disorders/?feed_id=47152 -
Scientists find link between #photosynthesis and 'fifth state of matter' (#BoseEinsteinCondensate)
"#Photosynthetic light harvesting is taking place in a system that is at room temperature and what's more, its structure is disordered—very unlike the pristine crystallized #materials and cold temperatures that you use to make #exciton #condensates."
https://phys.org/news/2023-05-scientists-link-photosynthesis-state.html
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“A University of Chicago study found links at the atomic level between photosynthesis and #exciton #condensates—a strange state of physics that allows energy to flow frictionlessly through a material. The finding is scientifically intriguing and may suggest new ways to think about designing electronics”
#UChicago
#Photosynthesis
#BoseEinsteinhttps://news.uchicago.edu/story/scientists-find-link-between-photosynthesis-and-fifth-state-matter
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Newly discovered #electrical activity within #cells could change the way researchers think about biological chemistry.
https://phys.org/news/2023-04-newly-electrical-cells-biological-chemistry.html
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Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=38696 -
Postdoctoral Position in Biological Physics @ZwickerGroup
Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.
#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=38116 -
🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature
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🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature
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🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature
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🧬 Malfunctioning #condensates in the cell can lead to the rare #BPTA syndrome, but also common diseases. This is a new #DiseaseMechanism, discovered our researchers in collaboration with #Charité Berlin and #UKSH, and published in the journal @Nature
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Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462 -
Ph.D. position in Biological Physics @ZwickerGroup
Come join us at @mpids for a #PhD in theoretical biophysics studying biomolecular #condensates.
#ScienceJobs #job @mpids
Göttingen #Germany #PhDStuden...
https://jobrxiv.org/job/max-planck-insitute-for-dynamics-and-self-organization-27778-ph-d-position-in-biological-physics-2/?feed_id=36462 -
Postdoctoral Position in Biological Physics @ZwickerGroup
Come join us at @mpids for an @ERC_Research funded #postdoc position to develop models of viscoelasticity of biomolecular #condensates.
#ScienceJobs #job @mpids #ER...
https://jobrxiv.org/job/max-planck-institute-for-dynamics-and-self-organization-27778-postdoctoral-position-in-biological-physics/?feed_id=36081 -
Happy to share new collaborative work on #singlemolecule imaging of biomolecular #condensates. They're less uniform than they seem! With #PappulabWashU @TingtingWu #MattKingLab #MinaFaragSci #WashUengineers
"Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates"
https://doi.org/10.1101/2023.01.26.525727