#ptm — Public Fediverse posts

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, this study shows how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @PLOSBiology https://plos.io/3KuS7m1

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, this study shows how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @PLOSBiology https://plos.io/3KuS7m1

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, this study shows how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @PLOSBiology https://plos.io/3KuS7m1

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, this study shows how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @PLOSBiology https://plos.io/3KuS7m1

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, this study shows how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @PLOSBiology https://plos.io/3KuS7m1

Platinum Asset Management ( #PTM ) has released " Funds Under Management - 30 April 2025 " on Tue 06 May at 09:15 AEST #Australia #live #ASX #management #Tech
https://grafa.com/asset/platinum-asset-management-ltd-3782-ptm.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=ptm.asx

Platinum Asset Management ( #PTM ) has released " Funds Under Management - March 2025 " on Mon 07 Apr at 16:49 AEST #Australia #ASX #management #Tech #Japan
https://grafa.com/asset/platinum-asset-management-ltd-3782-ptm.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=ptm.asx

Platinum Asset Management ( #PTM ) has released " Funds Under Management - February 2025 " on Fri 07 Mar at 16:16 AEST #Australia #ASX #management #Tech #Japan
https://grafa.com/asset/platinum-asset-management-ltd-3782-ptm.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=ptm.asx

#PTM-Mamba is a new #PTM-Aware #protein #language model (#pLM)

https://www.biorxiv.org/content/10.1101/2024.02.28.581983v1

Seeing the high recall and low precision scores makes me wonder if it is time to talk more about the high #imbalance in PTM data and the prevalence of #PositiveUnlabeled samples residues

MSII filtering can be applied to #RTI/
#PTM datasets when converted to 3D. Great cooperation with LDA Sachsen-Anhalt and
#Fraunhofer IFF
creating a curvature based 2D/3D benchmark dataset: https://doi.org/10.5334/joad.116 @nfdi4objects @nfdi4culture

Une splendide et spectaculaire découverte au @MusTemploMayor . Alejandra Aguirre et Antonio nous proposent un contexte incroyablement complexe et passionnant à la fois. Avec des photos non moins précises de Mirsa Islas.

http://rb.gy/1wk2l

#ptm #archaeology #arqueología #mexico #Tenochtitlan

When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience https://t.ly/HHyP

When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience https://t.ly/HHyP

When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience https://t.ly/HHyP

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem

And to put it in hashtags, in case that makes it easier to find...
#PARP
#ADPribosylation
#posttranslationalmodification
#PTM
#biochemistry
#cellbiology
#nanopore
#RNA
#proteins
#biophysics
#condensates
#SustainableScience
#greenlabs
#womeninscience
#womeninstem

Portugal. The Man pushing their own cryptocurrency now 😢 #PTM