home.social

#parp — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #parp, aggregated by home.social.

  1. europesays.com/pl/357258/ Polska sztuczna inteligencja ratuje serca noworodków. Ten system widzi to, co może umknąć lekarzowi #medtech #parp #PL #Poland #Polish #Polska #Polski #startup

  2. A regular firm favourite here on #CharityShopClassics Can’t resist a bit of High Quality #Parpage Herb Alpert - Bittersweet Samba £2 in Cats Protection I nearly didn’t get it, but it was on the Pye Label. On further inspection, is a South African Pressing in a Gatefold Sleeve #Parp

  3. Due to laziness, pressure of time and more laziness I will be having a creatively fashioned evening meal with the emphasis on pulses.

    #Parp

  4. The highest quality #CharityShopClassics #Parpage for you now Taken from Cassette - Ray Davis & His Button Down Brass - It’s Not Unusual #FunkyTrumpet Dedicated to @vinylcarbooty.bsky.social #Parp #BaBaBaa

  5. Some great work from an A/Prof Liz Caldon on predicting #PARP inhibition response in #cancer
    youtu.be/_Kej9mjRxzw?si=QlN_5C

  6. Some great work from an A/Prof Liz Caldon on predicting #PARP inhibition response in #cancer
    youtu.be/_Kej9mjRxzw?si=QlN_5C

  7. Some great work from an A/Prof Liz Caldon on predicting #PARP inhibition response in #cancer
    youtu.be/_Kej9mjRxzw?si=QlN_5C

  8. Some great work from an A/Prof Liz Caldon on predicting #PARP inhibition response in #cancer
    youtu.be/_Kej9mjRxzw?si=QlN_5C

  9. Unrepaired base excision repair #BER intermediates trigger #replication fork collapse and #PARP inhibitor sensitivity when present in template DNA strands, rather than in nascent strands behind forks – find Keith Caldecott, Steve Jackson, Nicolas Hoch and colleagues

    embopress.org/doi/full/10.1525

  10. Unrepaired base excision repair #BER intermediates trigger #replication fork collapse and #PARP inhibitor sensitivity when present in template DNA strands, rather than in nascent strands behind forks – find Keith Caldecott, Steve Jackson, Nicolas Hoch and colleagues

    embopress.org/doi/full/10.1525

  11. Unrepaired base excision repair #BER intermediates trigger #replication fork collapse and #PARP inhibitor sensitivity when present in template DNA strands, rather than in nascent strands behind forks – find Keith Caldecott, Steve Jackson, Nicolas Hoch and colleagues

    embopress.org/doi/full/10.1525

  12. Unrepaired base excision repair #BER intermediates trigger #replication fork collapse and #PARP inhibitor sensitivity when present in template DNA strands, rather than in nascent strands behind forks – find Keith Caldecott, Steve Jackson, Nicolas Hoch and colleagues

    embopress.org/doi/full/10.1525

  13. When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience t.ly/HHyP

  14. When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience t.ly/HHyP

  15. When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience t.ly/HHyP

  16. Did anyone else from team #ADPribosylation #PARP arrive on mastodon yet??
    Following them on the birdapp is the only reason I haven't deleted my account yet...

  17. Did anyone else from team #ADPribosylation #PARP arrive on mastodon yet??
    Following them on the birdapp is the only reason I haven't deleted my account yet...

  18. Did anyone else from team arrive on mastodon yet??
    Following them on the birdapp is the only reason I haven't deleted my account yet...

  19. Did anyone else from team #ADPribosylation #PARP arrive on mastodon yet??
    Following them on the birdapp is the only reason I haven't deleted my account yet...

  20. Discussion on #PARP resistance and multiple mechanisms that can lead to this challenging problem in the clinic.

    #POLtheta inhibitors may be able to overcome this resistance alone & w/PARP.

    ⬆️ levels of #POLtheta and certain mutations predict sensitivity

    #SABCS22 @[email protected]

  21. Discussion on #PARP resistance and multiple mechanisms that can lead to this challenging problem in the clinic.

    #POLtheta inhibitors may be able to overcome this resistance alone & w/PARP.

    ⬆️ levels of #POLtheta and certain mutations predict sensitivity

    #SABCS22 @[email protected]

  22. Dr Eileen O’Reilly at #MSK ordered germline & somatic testing soon after Jay’s diagnosis with #PancreaticCancer, years before it was an #ASCO guideline. He was found to have a gBRCA1 mutation - targetable by #PARP inhibitor #olaparib - allowing a welcome chemo break. So grateful for the eight years we had post-diagnosis.
    #PancreasCancer
    #BRCA

  23. Dr Eileen O’Reilly at #MSK ordered germline & somatic testing soon after Jay’s diagnosis with #PancreaticCancer, years before it was an #ASCO guideline. He was found to have a gBRCA1 mutation - targetable by #PARP inhibitor #olaparib - allowing a welcome chemo break. So grateful for the eight years we had post-diagnosis.
    #PancreasCancer
    #BRCA

  24. Dr Eileen O’Reilly at #MSK ordered germline & somatic testing soon after Jay’s diagnosis with #PancreaticCancer, years before it was an #ASCO guideline. He was found to have a gBRCA1 mutation - targetable by #PARP inhibitor #olaparib - allowing a welcome chemo break. So grateful for the eight years we had post-diagnosis.
    #PancreasCancer
    #BRCA

  25. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account

  26. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account

  27. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account