#chemicalproteomics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #chemicalproteomics, aggregated by home.social.
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Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes
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Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes
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Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes
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Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes
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Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes
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Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling
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Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling
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Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling
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Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling
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Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling
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Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.
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Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.
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Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.
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Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.
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Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.
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Congratulations to all authors! (4/4)
#ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #CovalentInhibitor
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Congratulations to all authors! (4/4)
#ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #CovalentInhibitor
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Congratulations to all authors! (4/4)
#ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #CovalentInhibitor
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Congratulations to all authors! (4/4)
#ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #CovalentInhibitor
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Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!
I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.
Check out details and registration here: https://lnkd.in/eWHFdTFx
#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio
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Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!
I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.
Check out details and registration here: https://lnkd.in/eWHFdTFx
#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio
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Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!
I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.
Check out details and registration here: https://lnkd.in/eWHFdTFx
#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio
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Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!
I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.
Check out details and registration here: https://lnkd.in/eWHFdTFx
#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio
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The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)
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The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)
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The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)
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The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)
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The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075 -
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075 -
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075 -
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075 -
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075 -
Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.
https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics -
Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.
https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics