#chemicalproteomics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #chemicalproteomics, aggregated by home.social.
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.
#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.
https://doi.org/10.26434/chemrxiv.15002030/v1
#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1 -
Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.
https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics -
"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.
#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B
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"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.
#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B
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"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.
#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B
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"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"
Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.
#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B
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We explored the question, from which different areas of chemistry, including glycochemistry, peptide chemistry, materials chemistry and synthetic method development new electrophiles for covalent inhibitors can originate in order to keep expanding the druggable space. (2/2)
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #Glycotime #Peptides #Materials #Synthesis #Undruggable #CovalentInhibitors
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Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.
https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro -
Very excited to visit Radboud University Nijmegen and to speak at the IMM colloquium. Looking forward to a full day of scientific exchange.
I am excited to present some of the newest work that our group performed at the @LED3hub in a brand new presentation. Curious how it will go and what the feedback will be.
Thank you for inviting me, Kevin Neumann.
#Chemistry #ChemBio #ChemPro #ProteoProbes #ChemicalProteomics
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Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
https://www.nature.com/articles/s41589-023-01355-w
#Chemistry #ChemBio #ChemPro #ProteoProbes -
Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery -
It was great that I could present our work at #ISCPDD. I focused on the isoDTB tags (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075) and our recent Nature Chemistry publication on the selectivity of diverse electrophiles (https://www.nature.com/articles/s41557-025-01902-z).
#ChemBio #Chemistry #ChemPro #ProteoProbes #ChemicalProteomics
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Great talk by Xiaoguang Lei at #ISCPDD. He talked about the identification of novel biosynthetic enzymes using #ChemicalProteomics and the use photoaffinity probes based on biosynthetic intermediates to fish for the relevant enzymes to identify e.g. an intermolecular Diels-Alderase.
https://www.nature.com/articles/s41557-020-0467-7
#Chemistry #ChemBio #ChemPro #ProteoProbes -
Great to see our Nature Chemistry paper out in its final published and printed form.
If you want to check it out, you can find it here: https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
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Exciting study by the group of Alexander Adibekian in JACS. They used antibodies modified with reversible, lysine-directed ketoboronates to develop KB-TACs as lysosomal degraders of membrane and extracellular proteins.
https://doi.org/10.1021/jacs.5c16611
#Chemistry #ChemBio #ChemicalProteomics #DrugDiscovery #TPD -
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics -
Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes -
Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)
https://doi.org/10.1101/2025.10.20.683548
#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes
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They also compared their identified ligand binding sites to those predicted by Boltz-2. They find that Boltz-2 predicts orthosteric binding well, but tends to also localize non-orthosteric binders to the orthosteric binding site. (2/2) #ChemSky #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes
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Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. https://doi.org/10.1038/s41592-024-02553-7
#Chemistry #ChemBio #DrugDiscovery -
Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. doi.org/10.1038/s415... #ChemSky #ChemBio #DrugDiscovery
A peptide-centric local stabil... -
Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery.
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Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery. #ChemSky
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I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2 -
A big thank you also to Stacey Paiva and her team at Nature Chemistry for their support and patience with me.
#CovalentInhibitor #DrugDiscovery #Proteomics #ChemicalProteomics #MassSpectrometry #Electrophiles #ProudPI #AcademicLife #NewPublication #Chemistry #ChemBio
(6/7) -
A big thank you also to Stacey Paiva and her team at Nature Chemistry for their support and patience with me.
#CovalentInhibitor #DrugDiscovery #Proteomics #ChemicalProteomics #MassSpectrometry #Electrophiles #ProudPI #AcademicLife #NewPublication #Chemistry #ChemBio
(6/7) -
A big thank you also to Stacey Paiva and her team at Nature Chemistry for their support and patience with me.
#CovalentInhibitor #DrugDiscovery #Proteomics #ChemicalProteomics #MassSpectrometry #Electrophiles #ProudPI #AcademicLife #NewPublication #Chemistry #ChemBio
(6/7) -
A big thank you also to Stacey Paiva and her team at Nature Chemistry for their support and patience with me.
#CovalentInhibitor #DrugDiscovery #Proteomics #ChemicalProteomics #MassSpectrometry #Electrophiles #ProudPI #AcademicLife #NewPublication #Chemistry #ChemBio
(6/7) -
A big thank you also to Stacey Paiva and her team at Nature Chemistry for their support and patience with me.
#CovalentInhibitor #DrugDiscovery #Proteomics #ChemicalProteomics #MassSpectrometry #Electrophiles #ProudPI #AcademicLife #NewPublication #Chemistry #ChemBio
(6/7) -
Excited that Christina Woo (Harvard University) will visit us for a @LED3hub Lecture.
Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #Chemistry and #ProteinDegradation.
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Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemistry #ChemBio -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032