#chemicalproteomics — Public Fediverse posts

I had a great time and hope to be back for the next event in 2028.

#CovalentInhibitor #DrugDiscovery #ChemicalProteomics #ChemBio #Chemistry #Science

(7/7)

Interesting talk by Darrin McKenzie at #CovModDrugDiscov.

He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells.

#CovalentInhibitor #DrugDiscovery #ChemBio #Chemistry #ChemicalProteomics #Science

The 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi.

He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics.

#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #ChemicalProteomics #Science

I am looking forward to an exciting meeting.

#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes
(2/2)

#ChemSky #Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes

Do you have experience in Organic Synthesis or Chemical Biology and are you looking for an exciting #postdoc position, in which you can apply your skills to the most exciting questions in microbiology? There are great opportunities available in the lab of Aaron Wright at Baylor University!

https://ejof.fa.us2.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX/job/19679?keyword=Postdoc%20Research%20Associate%20(Chemical%20Biology%20%2F%20Chemoproteomics)&mode=location&sortBy=POSTING_DATES_DESC

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #Synthesis #Microbes

Tom Muir
Matthew Disney
Laura Kiessling
Kathrin Lang
Peng Chen
(13/13)

#ChemBio #ChemicalBiology #Chemistry #DrugDiscovery #CovalentInhibitor #RNA #Glycotime #ChemicalProteomics #Protein #Imaging #Labeling

Interesting @biorxivpreprint by Seungmin Ahn and Jung-Min Kee. They developed a thioacetylene-based probe for the chemoproteomic profiling of protein-based radicals, especially thiyl radicals in E. coli.

https://doi.org/10.64898/2026.08.13.742689

#Chemistry #ChemBio #ChemPro #ChemicalProteomics

Congratulations to all authors! (4/4)

#ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #CovalentInhibitor

Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!

I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.

Check out details and registration here: https://lnkd.in/eWHFdTFx

#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio

The authors use affinity-based protein profiling with photoaffinity probes to elucidate PTM-dependent changes in protein ligandability in the proteome. To induce global changes of the PTM landscape, they use broad spectrum inhibitors like staurosporine to inhibit protein kinases and tunicamycin to inhibit N-linked glycosylation. Very interesting findings that many ligand interactions are affected either by direct or downstream effects. (2/2)

#ChemicalProteomics #ChemBio #DrugDiscovery #PAL #PTM

A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.

#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

RE: https://mstdn.science/@LED3hub/116002397339883235

Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.

If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.

#Chemistry #ChemBio #DrugDiscovery #degrader

We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".

If you are interested, make sure to come by!

https://www.universiteitleiden.nl/en/science/led3/led3-lectures

#ChemBio #Chemistry #ChemicalProteomics #TPD

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

Which cysteines are hyper-reactive in specific cancer types and tissues?

The lab of Balyn Zaro addresses this question by measuring cysteine reactivity across the whole NCI-60 panel that includes nine different cancer types.
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00396-4

Great to see them use the isoDTB tags that Patrick Zanon developed in our group for this extensive study. Glad that these tools are useful to other groups.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075

#ChemBio #Chemistry #ChemicalProteomics

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Excited to be at the meeting of the Institute for Chemical Neuroscience today. Looking forward to a great day of learning about #neuroscience on the clinical and molecular level as well as to discussing, how chemical tools can drive the field forward
https://i-cns.nl/en
#Chemistry #ChemBio #ChemicalProteomics

Excited to be at the meeting of the Institute for Chemical Neuroscience today. Looking forward to a great day of learning about #neuroscience on the clinical and molecular level as well as to discussing, how chemical tools can drive the field forward i-cns.nl/en #ChemSky #ChemBio #ChemicalProteomics

Excited to be at the meeting of the Institute for Chemical Neuroscience today. Looking forward to a great day of learning about #neuroscience on the clinical and molecular level as well as to discussing, how chemical tools can drive the field forward i-cns.nl/en #ChemSky #ChemBio #ChemicalProteomics

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

We explored the question, from which different areas of chemistry, including glycochemistry, peptide chemistry, materials chemistry and synthetic method development new electrophiles for covalent inhibitors can originate in order to keep expanding the druggable space. (2/2)

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #Glycotime #Peptides #Materials #Synthesis #Undruggable #CovalentInhibitors

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Very excited to visit Radboud University Nijmegen and to speak at the IMM colloquium. Looking forward to a full day of scientific exchange.

I am excited to present some of the newest work that our group performed at the @LED3hub in a brand new presentation. Curious how it will go and what the feedback will be.

Thank you for inviting me, Kevin Neumann.

#Chemistry #ChemBio #ChemPro #ProteoProbes #ChemicalProteomics

Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
https://www.nature.com/articles/s41589-023-01355-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery

It was great that I could present our work at #ISCPDD. I focused on the isoDTB tags (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075) and our recent Nature Chemistry publication on the selectivity of diverse electrophiles (https://www.nature.com/articles/s41557-025-01902-z).

#ChemBio #Chemistry #ChemPro #ProteoProbes #ChemicalProteomics

Great talk by Xiaoguang Lei at #ISCPDD. He talked about the identification of novel biosynthetic enzymes using #ChemicalProteomics and the use photoaffinity probes based on biosynthetic intermediates to fish for the relevant enzymes to identify e.g. an intermolecular Diels-Alderase.

https://www.nature.com/articles/s41557-020-0467-7
#Chemistry #ChemBio #ChemPro #ProteoProbes

Great to see our Nature Chemistry paper out in its final published and printed form.

If you want to check it out, you can find it here: https://www.nature.com/articles/s41557-025-01902-z

#Chemistry #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro

Exciting study by the group of Alexander Adibekian in JACS. They used antibodies modified with reversible, lysine-directed ketoboronates to develop KB-TACs as lysosomal degraders of membrane and extracellular proteins.

https://doi.org/10.1021/jacs.5c16611
#Chemistry #ChemBio #ChemicalProteomics #DrugDiscovery #TPD

Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)

https://doi.org/10.1101/2025.10.20.683548

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes

They also compared their identified ligand binding sites to those predicted by Boltz-2. They find that Boltz-2 predicts orthosteric binding well, but tends to also localize non-orthosteric binders to the orthosteric binding site. (2/2) #ChemSky #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes

Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. https://doi.org/10.1038/s41592-024-02553-7
#Chemistry #ChemBio #DrugDiscovery

Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. doi.org/10.1038/s415... #ChemSky #ChemBio #DrugDiscovery

A peptide-centric local stabil...

Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery.

Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery. #ChemSky

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

Research Scientist - Mass spectrometry - Ferguson Lab

University of California, San Diego

Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599

Research Scientist - Mass spectrometry - Ferguson Lab

University of California, San Diego

Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032