#tpd — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tpd, aggregated by home.social.
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
Exciting bioRxiv preprint by the group of Gunda Georg. They developed a tissue-specific PROTAC that recruits the E3 ligase scaffolding protein MAGEA11 that is highly expressed in many cancers and otherwise only in sperm and placenta. https://www.biorxiv.org/content/10.1101/2025.11.03.686228v1
#TPD #Chemistry #ChemBio -
Exciting study by the group of Alexander Adibekian in JACS. They used antibodies modified with reversible, lysine-directed ketoboronates to develop KB-TACs as lysosomal degraders of membrane and extracellular proteins.
https://doi.org/10.1021/jacs.5c16611
#Chemistry #ChemBio #ChemicalProteomics #DrugDiscovery #TPD -
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics -
Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes -
Interesting bioRxiv preprint by the groups of Peter Cossar and Alessio Ciulli. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC (MG-PROTAC) recruiting VHL. https://doi.org/10.1101/2025.11.17.688825
#DrugDiscovery #TPD #Chemistry #ChemBio -
Inspiring #Havinga Medal award lecture by Craig @crews at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio #TPDCongratulations, Craig Crews, on being recognized with this award for your truly groundbreaking work.
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Huge congratulations to Craig @crews from Yale on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#Chemistry #ChemBio #TPD -
Inspiring talk by Alex Bullock from the University of Oxford today at the Faculty of Science of Leiden University. He talked about his group's research into targeting proteins with mutations that cause neomorphic functions with inhibitors and degraders. https://www.nature.com/articles/s41467-025-58350-z
#ChemBio #Chemistry #DrugDiscovery #TPD -
We are very happy that Alex Bullock from the University of Oxford visited us today for a very well attended lecture. He talked about his group's work on making new E3 ligases available for degrader development using PROTACs and molecular glues. https://www.nature.com/articles/s41573-019-0047-y
#ChemBio #Chemistry #TPD #DrugDiscovery -
We are very excited to host Craig Crews
(@crews) - pioneer of targeted protein degradation as powerful modality in #DrugDisccovery - as one of the keynotes at the 5th Virtual @ChemBioTalks on September 30th.Register for free now: cvent.me/G1geWW
#ChemBio #Chemistry #TPD -
Great talk by Chris Parker of Scripps Research at the Dana Farber Targeted Protein Degradation Webinar Series.
He talked about his group's work on #ChemicalProteomic technologies and on new strategies to find protein degraders.
https://www.biorxiv.org/content/10.1101/2025.03.21.644652v1
#ChemBio #Chemistry #TPD -
Just published "Rarities in phonetics and phonology: Structural, typological, evolutionary, and social dimensions" edited by Natalia Kuznetsova, Cormac Anderson & Shelece Easterday #openaccess #tpd https://langsci-press.org/catalog/book/415
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Chemical Biology Postdoc in the Ferguson Lab at UCSD
University of California, San Diego
Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=91018 -
Just published "Epenthesis and beyond: Recent approaches to insertion in phonology and its interfaces" edited by Ji Yea Kim, Veronica Miatto, Andrija Petrović, & Lori Repetti. #openaccess #tpd https://langsci-press.org/catalog/book/469
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Chemical Biology Postdoc in the Ferguson Lab at UCSD
University of California, San Diego
Join our team working on #TPD #InducedProximity as a Postdoctoral fellow in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90...
https://jobrxiv.org/job/university-of-california-san-diego-27778-chemical-biology-postdoc-in-the-ferguson-lab-at-ucsd/?feed_id=90738 -
Interesting paper by the groups of Masoud Vedadi and Rima Al-awar in Nature Communications. New PROTACs for WDR5 that engage the E3 ligase DCAF1. Very interesting insights into the linker requirements from the ternary complex structure. #TPD #ChemBio https://doi.org/10.1038/s41467-024-54500-x
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Just published "Historical phonology of Mataguayan" by Andrey Nikulin & Javier Carol. #tpd #openaccess
https://langsci-press.org/catalog/book/413 -
Very interesting talk by Kyle Mangano of Amgen at the Dana-Farber Targeted Protein Degradation Webinar #TPD #TPDWebinar. He talked about his work on hijacking viral E3 ligases for targeted protein degradation using the VIPER-TAC modality. https://www.biorxiv.org/content/10.1101/2024.08.13.607762v1
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Just published "Constituency and convergence in the Americas" edited by Adam J. R. Tallman, Sandra Auderset & Hiroto Uchihara #openaccess #tpd https://langsci-press.org/catalog/book/291
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"PD-L1 is a promising target in cancer immunotherapy."
Strong candidate of understatement of the week, here on Monday.
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Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561
#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=72561 -
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Come and join us! Great opportunity for #postdoc or #phd in @TrujilloLab @RWTH to work in targeted protein degradation #TPD #endocytosis #ubiquitin
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644
#end...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis-2/?feed_id=71644 -
Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3 -
Postdoctoral Fellow - Ferguson Lab - Chemical Biology / Neurodegeneration @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #postdoc in cell/molecular biology to work on projects combining #TPD and #NeurodegenerativeDisease research!
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The Ferguson lab is recruiting for multiple postdoc positions in San Diego! @FleurMFerguson
Chemical Biology / Neurodegeneration
Med Chemistry, Chemical Biology
Cancer Chemical Biology, Pharmacology -
Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author -
Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or inefficient.
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Postdoctoral Fellow - Ferguson Lab - Chemical Biology / Neurodegeneration @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #postdoc in cell/molecular biology to work on projects combining #TPD and #NeurodegenerativeDisease research!
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Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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Our chemical tool #BCL6 #degrader is now available for free from the SGC as part of their donated chemical probes programme. We are very pleased to support this initiative which enables researchers to access quality tool compounds for their research. Remarkably, this is the first approved degrader on their list, with no doubt many more to follow! https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/CCT369260 #chemicalprobes #medchem #DrugDiscovery #tpd
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The eBook of Inducing Targeted Protein Degradation (Ed. Philipp Cromm, published by Wiley-VCH) is now available! Get yours today. Featuring a chapter by me and Erika Araujo. Print edition coming in December. #TPD #TargetedProteinDegradation #PROTAC
https://www.wiley.com/en-gb/Inducing+Targeted+Protein+Degradation%3A+From+Chemical+Biology+to+Drug+Discovery+and+Clinical+Applications-p-9783527350179 -
Interesting preprint @biorxivpreprint by the group of @DanNomura. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a #proteindegrader #TPD. Using #ABPP #ChemicalBiology, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. https://doi.org/10.1101/2022.11.04.512693
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I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup
