#tpd — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tpd, aggregated by home.social.
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Interesting paper by the groups of Jongmin Park, Juyong Lee and Hankum Park in Nature Communications. They developed muscle-specific PROTACs engaging the E3 ligase KLHL41. Great to see the most potent molecules with covalent KLHL41 ligands.
https://www.nature.com/articles/s41467-026-73252-4
#Chemistry #ChemBio #TPD -
Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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HESTA cuts new deal with AIA Australia, cuts fees
Home > Superannuation > HESTA cuts new deal with AIA Australia, cuts fees Mike Taylor Managing Editor and…
#NewsBeep #News #Australia #AIAAustralia #apra #AU #deathcover #groupinsurance #Hesta #performancetest #tpd
https://www.newsbeep.com/au/656327/ -
HESTA cuts new deal with AIA Australia, cuts fees
Home > Superannuation > HESTA cuts new deal with AIA Australia, cuts fees Mike Taylor Managing Editor and…
#NewsBeep #News #Australia #AIAAustralia #apra #AU #deathcover #groupinsurance #Hesta #performancetest #tpd
https://www.newsbeep.com/au/656327/ -
Second suspect arrested in crash that killed toddler at Country Club, Valencia
TUCSON, Ariz. (13 News) – A second suspect has been arrested after a …
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #BreakingNews #16-year-oldboyarrested #anna #ChristianIsaiahRandall #CountryClub #crash #Crime #Headlines #localnews #Pregnantwomaninjuredincrash #SamanthaBracamonte #streetracing #Topstories #TopStories #TPD #traffic #tucson #Tucsonnews #TucsonPolice
https://www.newsbeep.com/us/582987/ -
Second suspect arrested in crash that killed toddler at Country Club, Valencia
TUCSON, Ariz. (13 News) – A second suspect has been arrested after a …
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #BreakingNews #16-year-oldboyarrested #anna #ChristianIsaiahRandall #CountryClub #crash #Crime #Headlines #localnews #Pregnantwomaninjuredincrash #SamanthaBracamonte #streetracing #Topstories #TopStories #TPD #traffic #tucson #Tucsonnews #TucsonPolice
https://www.newsbeep.com/us/582987/ -
Second suspect arrested in crash that killed toddler at Country Club, Valencia
TUCSON, Ariz. (13 News) – A second suspect has been arrested after a high-speed crash at Valencia and…
#Spain #ES #Europe #Europa #EU #Valencia #16-year-oldboyarrested #Anna #breakingnews #ChristianIsaiahRandall #countryclub #crash #Crime #localnews #Pregnantwomaninjuredincrash #SamanthaBracamonte #streetracing #tpd #traffic #tucson #tucsonnews #tucsonpolice
https://www.europesays.com/spain/3990/ -
Toddler killed, suspect arrested in Tucson crash at Country Club, Valencia
TUCSON, Ariz. (13 News) – One man is facing a murder charge and authorities are looking for another…
#Spain #ES #Europe #Europa #EU #Valencia #Anna #breakingnews #ChristianIsaiahRandall #countryclub #crash #Crime #localnews #Pregnantwomaninjuredincrash #SamanthaBracamonte #tpd #traffic #tucson #tucsonnews #tucsonpolice
https://www.europesays.com/spain/2553/ -
Vehicle cut in half in Tucson deadly crash at Valencia, Country Club
TUCSON, Ariz. (13 News) – For the second time in little more than a month, authorities responded to…
#Spain #ES #Europe #Europa #EU #Valencia #breakingnews #countryclub #crash #localnews #tpd #traffic #tucson #tucsonnews #tucsonpolice
https://www.europesays.com/spain/822/ -
Crash shuts down Tucson intersection
TUCSON, Ariz. (13 News) – The Tucson Police Department says a serious crash has shut down an intersection.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #BreakingNews #crash #Headlines #road #roadclosure #Topstories #TopStories #TPD #traffic #tucson #TucsonPolice
https://www.newsbeep.com/us/528201/ -
https://www.europesays.com/sk/18477/ Veľký krach: Jeden z TOP slovenských e-shopov vyhlásil bankrot. Obrovské straty a dlhy, je to jeho koniec? #ANDREASHOP #EShop #elektronika #firmy #konkurz #krach #SK #Slovak #SlovakRepublic #Slovakia #Slovenčina #SlovenskáRepublika #Slovensko #TPD
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https://www.europesays.com/ch/30702/ Bringing proteins together to take cancer apart #BiomedicalResearch #cancer #Chemistry #DrugDiscovery #InducedProximity #Novartis #Oncology #SanDiego #TargetedProteinDegradation #TPD
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We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
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We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
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We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
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We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
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Police say at least two shot in Tucson
TUCSON, Ariz. (13 News) – The Tucson Police Department says at least two people are being treated for…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #BreakingNews #Crime #Headlines #localnews #Shooting #Topstories #TopStories #TPD #TucsonPolice #tucsonshooting #violentcrime
https://www.newsbeep.com/us/469167/ -
Police say at least two shot in Tucson
TUCSON, Ariz. (13 News) – The Tucson Police Department says at least two people are being treated for…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #BreakingNews #Crime #Headlines #localnews #Shooting #Topstories #TopStories #TPD #TucsonPolice #tucsonshooting #violentcrime
https://www.newsbeep.com/us/469167/ -
RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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RE: https://mstdn.science/@LED3hub/116002397339883235
Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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We are looking forward to the LED3 Lecture of Christina Woo on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
Exciting bioRxiv preprint by the group of Gunda Georg. They developed a tissue-specific PROTAC that recruits the E3 ligase scaffolding protein MAGEA11 that is highly expressed in many cancers and otherwise only in sperm and placenta. https://www.biorxiv.org/content/10.1101/2025.11.03.686228v1
#TPD #Chemistry #ChemBio -
Superannuation funds accused of delaying disability insurance claims
William Johns is deeply frustrated by the way some of Australia’s major superannuation funds are treating their members.…
#NewsBeep #News #Business #ASFA #AU #Australia #disbailityclaims #insurance #insuranceclaims #mentalhealthclaims #mentalheath #super #superconsumersaustralia #superfunds #superannuation #Totalandpermanentdisability #tpd
https://www.newsbeep.com/au/348050/ -
Exciting study by the group of Alexander Adibekian in JACS. They used antibodies modified with reversible, lysine-directed ketoboronates to develop KB-TACs as lysosomal degraders of membrane and extracellular proteins.
https://doi.org/10.1021/jacs.5c16611
#Chemistry #ChemBio #ChemicalProteomics #DrugDiscovery #TPD -
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics -
Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes -
Interesting bioRxiv preprint by the groups of Peter Cossar and Alessio Ciulli. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC (MG-PROTAC) recruiting VHL. https://doi.org/10.1101/2025.11.17.688825
#DrugDiscovery #TPD #Chemistry #ChemBio -
Inspiring #Havinga Medal award lecture by Craig @crews at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio #TPDCongratulations, Craig Crews, on being recognized with this award for your truly groundbreaking work.
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Inspiring #Havinga Medal award lecture by Craig @crews at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio #TPDCongratulations, Craig Crews, on being recognized with this award for your truly groundbreaking work.
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Inspiring #Havinga Medal award lecture by Craig @crews at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio #TPDCongratulations, Craig Crews, on being recognized with this award for your truly groundbreaking work.
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Huge congratulations to Craig @crews from Yale on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#Chemistry #ChemBio #TPD -
Huge congratulations to Craig @crews from Yale on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#Chemistry #ChemBio #TPD