#iscpdd — Public Fediverse posts

I hope I could convey some of the great science that was presented in >50 talks at the 3rd International Symposium on Chemical Proteomics and Drug Discovery in Guangzhou.

If you want to read my summaries, check out #ISCPDD.

Thank you so much again to Zhengqiu Li for organizing and inviting me.

#Chemistry #ChemBio #DrugDiscovery #Chemoproteomics #ChemPro #ProteoProbes

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Great presentation by Billy Ng at #ISCPDD. He talked about the use of induced proximity to study protein O-GlcNAcylation. Exciting work on recruiters that bring together OGT and a target protein.
https://pubs.acs.org/doi/full/10.1021/jacs.3c14380
#Chemistry #ChemBio #Glycotime

Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
https://www.nature.com/articles/s41589-023-01355-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

It was great that I could present our work at #ISCPDD. I focused on the isoDTB tags (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075) and our recent Nature Chemistry publication on the selectivity of diverse electrophiles (https://www.nature.com/articles/s41557-025-01902-z).

#ChemBio #Chemistry #ChemPro #ProteoProbes #ChemicalProteomics

Great talk by Xiaoguang Lei at #ISCPDD. He talked about the identification of novel biosynthetic enzymes using #ChemicalProteomics and the use photoaffinity probes based on biosynthetic intermediates to fish for the relevant enzymes to identify e.g. an intermolecular Diels-Alderase.

https://www.nature.com/articles/s41557-020-0467-7
#Chemistry #ChemBio #ChemPro #ProteoProbes

Great talk by Cheng Chang at #ISCPDD. He talked about his group’s work on πPrimeNovo for de novo sequencing in mass spectrometry-based #proteomics. He also presented the πHub database of human proteomics data.
https://www.nature.com/articles/s41467-024-55021-3
#MS #MassSpectrometry #DeNovoSequencing

Great talk by Clive Chung at #ISCPDD. He presented his work on the use of #ChemcalProteomics to find cysteine-directed covalent inhibitors. Exciting insights into the NAIA chemistry as well as into the application to specific proteins of interest.
https://www.nature.com/articles/s41467-023-39268-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics

Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes