#iscpdd — Public Fediverse posts

I hope I could convey some of the great science that was presented in >50 talks at the 3rd International Symposium on Chemical Proteomics and Drug Discovery in Guangzhou.

If you want to read my summaries, check out #ISCPDD.

Thank you so much again to Zhengqiu Li for organizing and inviting me.

#Chemistry #ChemBio #DrugDiscovery #Chemoproteomics #ChemPro #ProteoProbes

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Great presentation by Billy Ng at #ISCPDD. He talked about the use of induced proximity to study protein O-GlcNAcylation. Exciting work on recruiters that bring together OGT and a target protein.
https://pubs.acs.org/doi/full/10.1021/jacs.3c14380
#Chemistry #ChemBio #Glycotime

Great talk by Nathanael Gray at #ISCPDD. He presented his group’s work on induced proximity to regulate transcription. Exciting data on recruiting a transcriptional activator (e.g. BRD4 or CDK9) to replace co-repressors on the death regulator BCL6 to induce cell death.

https://www.nature.com/articles/s41586-023-06348-2
#Chemistry #ChemBio #InducedProximity

Great talk by Xinyuan Fan at #ISCPDD. He talked about his group’s exciting work on using #photocatalysis to profile the proteins and the RNA in specific compartments in the cell on the example of mitochondria, Golgi, ER and lysosome.
https://doi.org/10.1038/s41557-025-01946-1
#ChemBio #Chemistry #ProximityLabeling

Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
https://www.nature.com/articles/s41589-023-01355-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery

It was great that I could present our work at #ISCPDD. I focused on the isoDTB tags (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075) and our recent Nature Chemistry publication on the selectivity of diverse electrophiles (https://www.nature.com/articles/s41557-025-01902-z).

#ChemBio #Chemistry #ChemPro #ProteoProbes #ChemicalProteomics

Interesting talk by Lei Wang at #ISCPDD. He talked about the application and synthetic optimization of natural products as #antibiotics against the most relevant #bacteria.

https://www.nature.com/articles/s41467-024-49629-8
#Chemistry #ChemBio #DrugDiscovery

Great talk by Xiaoguang Lei at #ISCPDD. He talked about the identification of novel biosynthetic enzymes using #ChemicalProteomics and the use photoaffinity probes based on biosynthetic intermediates to fish for the relevant enzymes to identify e.g. an intermolecular Diels-Alderase.

https://www.nature.com/articles/s41557-020-0467-7
#Chemistry #ChemBio #ChemPro #ProteoProbes

Great talk by Cheng Chang at #ISCPDD. He talked about his group’s work on πPrimeNovo for de novo sequencing in mass spectrometry-based #proteomics. He also presented the πHub database of human proteomics data.
https://www.nature.com/articles/s41467-024-55021-3
#MS #MassSpectrometry #DeNovoSequencing

Interesting talk by Xiangbing Qi at #ISCPDD. He talked about the design of compound libraries for high-throughput screening and their biological applications. Interesting applications of Herbert Waldmann’s Spacial Score metric. https://doi.org/10.1021/acs.jmedchem.3c00689
#HTS #Screening #Chemistry #DrugDiscovery

Interesting talk by Yun He at #ISCPDD. He talked about his group’s work on small molecule-drug conjugates for targeting specific cells. Great insights into the use of siderophore conjugates to get molecules into Gram-negative #bacteria.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202204139
#Antibiotics #Chemistry #ChemBio #DrugDiscovery

Insightful presentation by Minjia Tan at #ISCPDD. She talked about her group’s research into the use of the photoactivated ortho-nitrobenzyl alcohol (oNBA) reactive group and its application to studying protein complexes in live cells.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202507254
#ChemSky #ChemBio #Electrophiles #Crosslinking #XLMS

Great talk by Clive Chung at #ISCPDD. He presented his work on the use of #ChemcalProteomics to find cysteine-directed covalent inhibitors. Exciting insights into the NAIA chemistry as well as into the application to specific proteins of interest.
https://www.nature.com/articles/s41467-023-39268-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

Great talk by Itaru Hamachi at #ISCPDD. He talked about his group’s research into PhoxID. In this method, endogenous proteins are labeled with a photocatalyst by ligand-directed chemistry and used for proximity labeling of their environment.
https://www.pnas.org/doi/10.1073/pnas.2313887121
#Chemistry #ChemBio #ProximityLabeling

Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
https://pubs.acs.org/doi/full/10.1021/jacs.4c18083
#TPD #Chemistry #ChemBio #ChemicalProteomics

Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes

Great talk by Xuechen Li at #ISCPDD. He talked about the use of #miniproteins in #DrugDiscovery. Exciting insights into the synthesis of large libraries and their screening by #PhageDisplay including the use of mirror image phage display.

https://pubs.acs.org/doi/10.1021/jacsau.5c01181

#Chemistry #ChemBio #Peptides

Great talk by Xuechen Li at #ISCPDD. He talked about the use of #miniproteins in #DrugDiscovery. Exciting insights into the synthesis of large libraries and their screening by #PhageDisplay including the use of mirror image phage display. pubs.acs.org/doi/10.1021/... #ChemSky #ChemBio #Peptides

Discovery of d-Miniprotein Inh...

Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. https://doi.org/10.1038/s41592-024-02553-7
#Chemistry #ChemBio #DrugDiscovery

Insightful talk by Mingliang Ye at #ISCPDD. She talked about the use of #ChemicalProteomics for the study of target engagement in complex biological systems. Exciting insights into peptide-centric local stability assay (PELSA) and SICFA. doi.org/10.1038/s415... #ChemSky #ChemBio #DrugDiscovery

A peptide-centric local stabil...

Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery.

Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery. #ChemSky

It was a great pleasure to be at the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou. A huge thank you to Zhengqiu Li for the invitation and amazing hospitality. We had an amazing program. I will post some updates here soon.
#ChemBio #Chemistry #DrugDiscovery