#abpp — Public Fediverse posts

RE: https://mstdn.science/@ABPP2027/116882439891258603

Very excited for the #ABPP conference in Leiden on June 2nd to 4th, 2027. Great news that we have Oncode Accelerator on board.

Are you also interested in being visible at this event? Reach out at [email protected] for sponsoring options.

Mailing list for all information: https://fd24.formdesk.com/universiteitleiden/ABPP

Very excited for the #ABPP conference in Leiden on June 2nd to 4th, 2027. Great news that we have Oncode Accelerator on board.

Are you also interested in being visible at this event? Reach out at [email protected] for sponsoring options.

Mailing list: fd24.formdesk.com/universiteit...

RE: https://bsky.app/profile/did:plc:4tytwyqkv6ha2gxkkc6bitq5/post/3mq4bdg6tf22q

Very much looking forward to the Symposium 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 in Cambridge (UK) on October 7th/8th!

I am very happy to be part of an amazing lineup of speakers including Ed Tate, Matthias Gehringer, Louise Walport, Megan Wright, Elena De Vita, Matthew Bogyo, Scott Lovell, David Heppner, Jonathan Pettinger and Steven Gygi.

Check out details and registration here: https://lnkd.in/eWHFdTFx

#DrugDiscovery #ABPP #ChemicalProteomics #Symposium #ChemBio

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)

https://doi.org/10.1101/2025.10.20.683548

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2) doi.org/10.1101/2025...

Tryptoline Stereoprobe Elabora...

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in @angewandtechemie.bsky.social. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemsky onlinelibrary.wiley....

Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in Angewandte Chemie. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemistry https://onlinelibrary.wiley.com/doi/10.1002/anie.202505581

#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#Chemistry #ChemBio

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!

If you are there on Saturday or Sunday morning and want to catch up, send me a message!

#ABPP #ChemBio

https://www.eventcreate.com/e/abpp2025/

He then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of #ABPP to study this modification. (3/5) https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00151

Inspiring keynote lecture by Uwe Grether of Roche at the #Lunteren meeting of the #SOC and #MCCB divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including #ABPP, #AI, #LSF and #HTE.

If you are looking for exciting scientific content (with a focus on #ChemBio, #Chemistry, #ABPP, #ChemicalProteomics) over on bluesky, check out these starter packs:
short list: https://go.bsky.app/C4URhFa
pack 1: https://go.bsky.app/3SyoVNw
pack 2: https://go.bsky.app/9keb2TP

Interesting preprint @biorxivpreprint by the group of @DanNomura. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a #proteindegrader #TPD. Using #ABPP #ChemicalBiology, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. https://doi.org/10.1101/2022.11.04.512693