#abpp — Public Fediverse posts

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)

#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)

https://doi.org/10.1101/2025.10.20.683548

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2) doi.org/10.1101/2025...

Tryptoline Stereoprobe Elabora...

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#Chemistry #ChemBio #DrugDiscovery #ABPP
https://www.nature.com/articles/s41587-025-02737-2

Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in @angewandtechemie.bsky.social. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemsky onlinelibrary.wiley....

Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in Angewandte Chemie. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemistry https://onlinelibrary.wiley.com/doi/10.1002/anie.202505581

#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#Chemistry #ChemBio

#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#Chemistry #ChemBio

#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#Chemistry #ChemBio

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!

If you are there on Saturday or Sunday morning and want to catch up, send me a message!

#ABPP #ChemBio

https://www.eventcreate.com/e/abpp2025/

Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!

If you are there on Saturday or Sunday morning and want to catch up, send me a message!

#ABPP #ChemBio

https://www.eventcreate.com/e/abpp2025/

Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!

If you are there on Saturday or Sunday morning and want to catch up, send me a message!

#ABPP #ChemBio

https://www.eventcreate.com/e/abpp2025/

He then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of #ABPP to study this modification. (3/5) https://pubs.acs.org/doi/full/10.1021/acs.jproteome.3c00151

Inspiring keynote lecture by Uwe Grether of Roche at the #Lunteren meeting of the #SOC and #MCCB divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including #ABPP, #AI, #LSF and #HTE.

If you are looking for exciting scientific content (with a focus on #ChemBio, #Chemistry, #ABPP, #ChemicalProteomics) over on bluesky, check out these starter packs:
short list: https://go.bsky.app/C4URhFa
pack 1: https://go.bsky.app/3SyoVNw
pack 2: https://go.bsky.app/9keb2TP

Interesting preprint @biorxivpreprint by the group of @DanNomura. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a #proteindegrader #TPD. Using #ABPP #ChemicalBiology, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. https://doi.org/10.1101/2022.11.04.512693