#proteindegrader — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #proteindegrader, aggregated by home.social.
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Interesting preprint @biorxivpreprint by the group of @DanNomura. They put an electrophilic handle on the CDK4/6 inhibitor Ribociclib and show that it converts it into a #proteindegrader #TPD. Using #ABPP #ChemicalBiology, they identify RNF126 as responsible E3 ligase. Furthermore, they identify a minimal motif engaging RNF126 and use it to convert various protein ligands into degraders for e.g. CDK4, BCR-ABL and c-ABL, PDE5, BRD4, AR and AR-V7, BTK, SMARCA2, and LRRK2. https://doi.org/10.1101/2022.11.04.512693