#chempro — Public Fediverse posts

A couple of weeks back I had the great opportunity to present some of our group's recent work in a virtual presentation at Rutgers University. A huge thank you to Joel Freundlich and Stephen Burley for inviting me (and for the gift that I just received). Thank you also to all that took the time to attend and participate in the discussion.

#ChemicalProteomics #ChemPro #Presenting #Science #Chemistry

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

We explored the question, from which different areas of chemistry, including glycochemistry, peptide chemistry, materials chemistry and synthetic method development new electrophiles for covalent inhibitors can originate in order to keep expanding the druggable space. (2/2)

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #Glycotime #Peptides #Materials #Synthesis #Undruggable #CovalentInhibitors

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)

https://doi.org/10.1101/2025.10.20.683548

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes