#covalent — Public Fediverse posts

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-27-drug-discovery-on-an-undruggable-activity-7452806289342164992-ii04?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery

Планировщики процессов для необычных областей знаний

Продолжаем обсуждать примечательные инструменты для автоматизации и управления рабочими процессами (и напоминаем про

https://habr.com/ru/companies/mws/articles/919126/

#workflow #работа_с_данными #Covalent #Cromwell #Cylc #Martian #MWS #MWS_Tables

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

Great keynote lecture by Marta Artola of the @LED3hub at #Lunteren. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked #covalent and non-covalent #inhibitors and #probes.
#chemistry #ChemBio
https://pubs.acs.org/doi/10.1021/jacs.2c05666

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author