#covalent — Public Fediverse posts

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-27-drug-discovery-on-an-undruggable-activity-7452806289342164992-ii04?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-27-drug-discovery-on-an-undruggable-activity-7452806289342164992-ii04?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

Great talk by Phillip Yesley from the group of Wim Velema at #Lunteren2026.

He discussed the use of mutational profiling to find covalent ligands for structured #RNA using acyl imidazoles as the reactive group.

https://onlinelibrary.wiley.com/doi/10.1002/ange.202517243
#Chemistry #ChemBio #Covalent #CovalentInhibitor

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery

Very excited that our group was awarded an NWO XS grant to support our research into new #covalent #antibiotics for Gram-negative bacteria!

Thank you to Storm van der Voort for help with finalizing the proposal.

Congratulations also to all other recipients of the grant!

https://www.nwo.nl/en/news/48-grants-for-the-open-competition-domain-science-xs
#ChemSky #ChemBio

Планировщики процессов для необычных областей знаний

Продолжаем обсуждать примечательные инструменты для автоматизации и управления рабочими процессами (и напоминаем про

https://habr.com/ru/companies/mws/articles/919126/

#workflow #работа_с_данными #Covalent #Cromwell #Cylc #Martian #MWS #MWS_Tables

Excited that our group was awarded a KIEM grant in collaboration with the group of Wiep Klaas Smits. Using this grant, we will establish new interdisciplinary connections and explore the development of #covalent #antibiotics against C. difficile.

https://www.staff.universiteitleiden.nl/news/2025/05/results-kiem-lottery-2025

Fanboy moment for me today at #FocusOnCovalentDrugs. Hearing Matthias Gehringer present for the first time. His reviews on covalent warheads are a must-read in my group for many years now.

#Chemistry #ChemBio #DrugDiscovery #covalent

https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01153
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01825

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio

Great keynote lecture by Marta Artola of the @LED3hub at #Lunteren. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked #covalent and non-covalent #inhibitors and #probes.
#chemistry #ChemBio
https://pubs.acs.org/doi/10.1021/jacs.2c05666

Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #MachineLearning
https://chemrxiv.org/engage/chemrxiv/article-details/658de2e266c13817293b8174

Thrilled to share our story on the first rationally designed #covalent #HDAC inhibitor! YSR734 uses an SNAr-reactive electrophile to engage a noncatalytic nitrosylation site cysteine in #HDAC2, showing in vitro activity in AML & #DuchenneMuscularDystrophy!
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01236

#JournalClub summaries of the CCC group meetings are now available online - just click the topic of your interest https://www.h-its.org/research/ccc/events/ The first slide deck from Dr. Michelle Ernst is on #intermolecular #covalent #interactions More to come on bonding & interactions!

#JournalClub summaries of the CCC group meetings are now available online - just click the topic of your interest https://www.h-its.org/research/ccc/events/ The first slide deck from Dr. Michelle Ernst is on #intermolecular #covalent #interactions More to come on bonding & interactions!

Great to see this paper by the groups of @mariovdstelt and Nathaniel Martin with first authors Alexander Bakker and Ioli Kotsogianni out in JACS. Exciting chemical biology and medicinal chemistry research to identify a new #covalent #antibiotic with activity in MRSA. @LED3hub https://doi.org/10.1021/jacs.2c10819

Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author

Interesting work by Samy Meroueh @IUMedSchool on the development and characterization of reversible #covalent cyanamide antagonists of TEAD-YAP1 that engage a conserved cysteine palmitoylation site in #TEAD.
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.2c01189

@Artanicus funny but not really because you are looking to attack the #coronavirus lipid bi-layer (w proteins inside) which is actually very tough
- way to do that is #saponification which would be by lye (#sodiumhydroxide) attacking the actual lipids
- or the soap benefit from saponification which is the #covalent attraction of lipid side of #soap
- or, my hypothesis, actually attach it to fully-covalent mineral oil aka #babyoil until you can get to soap, or coconut oil