#inhibitor — Public Fediverse posts

#Human ACE2‑specific benzothiazole-based allosteric #inhibitor against pan ‑ #sarbecoviruses, https://etidiohnew.blogspot.com/2026/06/human-ace2specific-benzothiazole-based.html

Computational #design of an ultrapotent #deltacoronavirus miniprotein #inhibitor, https://etidiohnew.blogspot.com/2026/05/computational-design-of-ultrapotent.html

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-27-drug-discovery-on-an-undruggable-activity-7452806289342164992-ii04?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

The virus entry #inhibitor ARN-75039 provides therapeutic #protection against #Lassa virus infection in guinea pigs, https://etidiohnew.blogspot.com/2026/04/the-virus-entry-inhibitor-arn-75039.html

A #clinical #SARS-CoV-2 #Mpro #inhibitor blocks replication of multiple #enteroviruses and confers oral in vivo protection in animal models, https://etidiohnew.blogspot.com/2026/03/a-clinical-sars-cov-2-mpro-inhibitor.html

Coadministration of #ribavirin and #arenaviral entry #inhibitor LHF-535 enhances antiviral benefit against authentic #Lassa virus, https://etidiohnew.blogspot.com/2025/04/coadministration-of-ribavirin-and.html

A #coronavirus assembly #inhibitor that targets the viral #membrane protein, https://etidiohnew.blogspot.com/2025/03/a-coronavirus-assembly-inhibitor-that.html

Unveiling the ethylene-inhibiting mechanism of the allelochemical Myrigalone A 🌱🧪

👉 https://www.mauromaver.eu/posts/posts_omnia/focus_II/2/

#Science #Research #academia #PlantScience #Plant #scientificwriting #editorial #allelopathy #ethylene #inhibitor

#Synergistic activity of an #RNA #polymerase PA-PB1 interaction #inhibitor with #oseltamivir vs #human & avian #influenza viruses in #cell culture & in ovo, Antiviral Res.: https://www.sciencedirect.com/science/article/abs/pii/S016635422400189X?via%3Dihub

The PA-PB1 interaction inhibitor '54' acts synergistically with oseltamivir vs influenza A & B. '54' & oseltamivir combined at low doses inhibit viral progeny production & proteins expression in cell culture. 54 inhibits avian influenza replication both in cell culture & in embryonated chicken eggs.

#Efficacy of #host #cell serine #protease #inhibitor MM3122 against #SARS-CoV-2 for #treatment and #prevention of #COVID19, J Virol.: https://doi.org/10.1128/jvi.01903-23

Herein, we demonstrate that MM3122 potently inhibits viral replication in human lung epithelial cells and is also effective against the EG.5.1 variant of SARS-CoV-2.

Effect of #ACE #Inhibitor and #ARB Initiation on Organ Support–Free Days in #Patients Hospitalized With #COVID19
A Randomized Clinical Trial - JAMA: https://jamanetwork.com/journals/jama/fullarticle/2803515?guestAccessKey=4694d866-267a-4a5d-9bbb-54479425c945&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=etoc&utm_term=041123

TRPC6 #inhibitor (BI 764198) to reduce #risk and severity of #ARDS due to #COVID19: a phase II randomised controlled trial http://thorax.bmj.com/cgi/content/short/thorax-2022-219668v1?rss=1

Design of CD73 #inhibitor|s

Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.

#MedChem @chemistry #Science #Research

https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01287

#CUO246 from #Novartis is a promising DNA #gyrase/#topoisomerase IV dual #inhibitor active against Gram-positive and Gram-negative #bacteria.
https://journals.asm.org/doi/full/10.1128/aac.00921-22