#antibiotic — Public Fediverse posts

Experimental #antibiotic kills deadly #superbug, opens whole new class of #drugs
Relatively large molecule clogs a transport system, leading to lethal toxicity. In this case, the new #drug—dubbed #zosurabalpin—fights off the #GramNegative #bacterium carbapenem-resistant Acinetobacter baumannii, aka CRAB. Though it may sound obscure, it's an opportunistic, invasive #bacteria that often strikes hospitalized and critically ill patients, causing deadly #infections worldwide. https://arstechnica.com/science/2024/01/experimental-antibiotic-reveals-entirely-new-way-to-kill-drug-resistant-bacteria/

At last some good news:
Scientists hail new #antibiotic that can kill drug-resistant bacteria

#Zosurabalpin has defeated strains of pneumonia and sepsis in mice, raising hopes for human trials
https://www.theguardian.com/science/2024/jan/03/scientists-new-class-antibiotic-kill-drug-resistant-bacteria?CMP=Share_AndroidApp_Other

Scientists hail new antibiotic that can kill drug-resistant bacteria | Infectious diseases | The Guardian
https://www.theguardian.com/science/2024/jan/03/scientists-new-class-antibiotic-kill-drug-resistant-bacteria

#Antibiotic
#DrugResistantBacteria
#NewAntibiotic
#Zosurabalpin
#Sepsis
#LPS
#Lipopolysaccharide
#GramNegativeBacteria

This is interesting - providing individualised antibiotic plans safely reduces #carbapenem prescriptions.

But isn't this just what happens in specialties, like #hematology or #intensivecare, that get regular #microbiology / #infectiousdisease #MDT review of their #antibiotic prescriptions?
#IDmastodon #medicine #oncology #orthopedics #ICU #AMR #pediatrics #criticalcare
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad518/7255898?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=cid&utm_medium=email

Based on a nanosystem, the core of which is #polyoxometalate (containing #molybdenum and iron). A broad-spectrum #antibiotic, #tetracycline, is attached to the surface of the polyoxometalate.
#Chemistry #Nanotechnology #Pharmaceutical #sflorg
https://www.sflorg.com/2023/01/nt01182301.html