#proteoprobes — Public Fediverse posts

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

RE: https://mstdn.science/@ABPP2027/116136570431382767

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am very excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: https://www.universiteitleiden.nl/en/science/led3/abpp2027

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #Chemistry #ChemBio #DrugDiscovery

Interesting paper by the group of Rolf Breinbauer in Organic & Biomolecular Chemistry. They synthesized three α-fluoromethyl naphthoquinone-based probes as potentially reduction-activated probes for oxidoreductases, but found promiscuous reactivity.

https://pubs.rsc.org/en/content/articlelanding/2025/ob/d5ob01320h
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes #ChemicalProteomics

Very excited to see this study by the group of David Konrad out in JACS Au.

Ortho-dichloroacrylophenone is a highly reactive, cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

https://pubs.acs.org/doi/10.1021/jacsau.5c00692
#ChemBio #Chemistry #ChemPro #ProteoProbes #CovalentInhibitors

Interesting bioRxiv preprint by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

https://www.biorxiv.org/content/10.1101/2025.10.13.681063v1
#Chemistry #ChemBio #ABPP #ChemPro #ProteoProbes

We explored the question, from which different areas of chemistry, including glycochemistry, peptide chemistry, materials chemistry and synthetic method development new electrophiles for covalent inhibitors can originate in order to keep expanding the druggable space. (2/2)

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes #DrugDiscovery #Glycotime #Peptides #Materials #Synthesis #Undruggable #CovalentInhibitors

I hope I could convey some of the great science that was presented in >50 talks at the 3rd International Symposium on Chemical Proteomics and Drug Discovery in Guangzhou.

If you want to read my summaries, check out #ISCPDD.

Thank you so much again to Zhengqiu Li for organizing and inviting me.

#Chemistry #ChemBio #DrugDiscovery #Chemoproteomics #ChemPro #ProteoProbes

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Very excited to visit Radboud University Nijmegen and to speak at the IMM colloquium. Looking forward to a full day of scientific exchange.

I am excited to present some of the newest work that our group performed at the @LED3hub in a brand new presentation. Curious how it will go and what the feedback will be.

Thank you for inviting me, Kevin Neumann.

#Chemistry #ChemBio #ChemPro #ProteoProbes #ChemicalProteomics

Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
https://www.nature.com/articles/s41589-023-01355-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

It was great that I could present our work at #ISCPDD. I focused on the isoDTB tags (https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201912075) and our recent Nature Chemistry publication on the selectivity of diverse electrophiles (https://www.nature.com/articles/s41557-025-01902-z).

#ChemBio #Chemistry #ChemPro #ProteoProbes #ChemicalProteomics

Great talk by Xiaoguang Lei at #ISCPDD. He talked about the identification of novel biosynthetic enzymes using #ChemicalProteomics and the use photoaffinity probes based on biosynthetic intermediates to fish for the relevant enzymes to identify e.g. an intermolecular Diels-Alderase.

https://www.nature.com/articles/s41557-020-0467-7
#Chemistry #ChemBio #ChemPro #ProteoProbes

Great to see our Nature Chemistry paper out in its final published and printed form.

If you want to check it out, you can find it here: https://www.nature.com/articles/s41557-025-01902-z

#Chemistry #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro

Great talk by Clive Chung at #ISCPDD. He presented his work on the use of #ChemcalProteomics to find cysteine-directed covalent inhibitors. Exciting insights into the NAIA chemistry as well as into the application to specific proteins of interest.
https://www.nature.com/articles/s41467-023-39268-w
#Chemistry #ChemBio #ChemPro #ProteoProbes

Geat talk by Yu Rao at #ISCPDD. He talked about his group’s work on PROTACs and the use of degradation-based protein profiling (DBPP) to characterize target engagement.
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202308186
#TPD #Chemistry #ChemBio #DrugDiscovery #ChemicalProteomics #ChemPro #ProteoProbes

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo of Scripps Research with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)

https://doi.org/10.1101/2025.10.20.683548

#Chemistry #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes

They also compared their identified ligand binding sites to those predicted by Boltz-2. They find that Boltz-2 predicts orthosteric binding well, but tends to also localize non-orthosteric binders to the orthosteric binding site. (2/2) #ChemSky #ChemBio #ChemicalProteomics #ChemPro #ProteoProbes