#covalentinhibitors — Public Fediverse posts

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

A covalent KEAP1 activator in the clinics: A team at Vividion led by Matt Patricelli developed a covalent molecular glue for KEAP1, which leads to suppression of NRF2-dependent cancer growth. Excited to see, how the three clinical programs that Vividion built based on #CovalentInhibitors discovered by #ChemicalProteomics will progress. (7/12)
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1187/771133/A-covalent-allosteric-molecular-glue-suppresses?searchresult=1

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors

Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases

Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases

Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases

Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases

Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases

Amazing paper by the groups of Li Ye and Ben Cravatt of @scripps.edu in @cp-cell.bsky.social. They developed the vCATCH method to map in vivo, to which tissues and cell types #CovalentInhibitors bind with spatial resolution in whole intact mouse bodies. https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013650%3Fshowall%3Dtrue
#Chemistry #ChemBio

Amazing paper by the groups of Li Ye and Ben Cravatt of @scripps.edu in @cp-cell.bsky.social. They developed the vCATCH method to map in vivo, to which tissues and cell types #CovalentInhibitors bind with spatial resolution in whole intact mouse bodies. https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013650%3Fshowall%3Dtrue
#Chemistry #ChemBio

Amazing paper by the groups of Li Ye and Ben Cravatt of @scripps.edu in @cp-cell.bsky.social. They developed the vCATCH method to map in vivo, to which tissues and cell types #CovalentInhibitors bind with spatial resolution in whole intact mouse bodies. https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013650%3Fshowall%3Dtrue
#Chemistry #ChemBio

Amazing paper by the groups of Li Ye and Ben Cravatt of @scripps.edu in @cp-cell.bsky.social. They developed the vCATCH method to map in vivo, to which tissues and cell types #CovalentInhibitors bind with spatial resolution in whole intact mouse bodies. https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013650%3Fshowall%3Dtrue
#Chemistry #ChemBio

Amazing paper by the groups of Li Ye and Ben Cravatt of @scripps.edu in @cp-cell.bsky.social. They developed the vCATCH method to map in vivo, to which tissues and cell types #CovalentInhibitors bind with spatial resolution in whole intact mouse bodies. https://www.cell.com/cell/fulltext/S0092-8674(25)01365-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425013650%3Fshowall%3Dtrue
#Chemistry #ChemBio

Very excited to see this study by the group of David Konrad out in JACS Au.

Ortho-dichloroacrylophenone is a highly reactive, cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

https://pubs.acs.org/doi/10.1021/jacsau.5c00692
#ChemBio #Chemistry #ChemPro #ProteoProbes #CovalentInhibitors

Very excited to see this study by the group of David Konrad out in JACS Au.

Ortho-dichloroacrylophenone is a highly reactive, cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

https://pubs.acs.org/doi/10.1021/jacsau.5c00692
#ChemBio #Chemistry #ChemPro #ProteoProbes #CovalentInhibitors

Very excited to see this study by the group of David Konrad out in JACS Au.

Ortho-dichloroacrylophenone is a highly reactive, cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

https://pubs.acs.org/doi/10.1021/jacsau.5c00692
#ChemBio #Chemistry #ChemPro #ProteoProbes #CovalentInhibitors

Very excited to see this study by the group of David Konrad out in JACS Au.

Ortho-dichloroacrylophenone is a highly reactive, cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

https://pubs.acs.org/doi/10.1021/jacsau.5c00692
#ChemBio #Chemistry #ChemPro #ProteoProbes #CovalentInhibitors

Interesting paper by the group of Alexander Dömling in Green Chemistry. They used an Ugi four-component reaction followed by product precipitation for the efficient synthesis and purification of a >1200-member acrylamide library.

https://pubs.rsc.org/en/content/articlelanding/2025/gc/d5gc04440e
#CovalentInhibitors #Chemistry #ChemBio

Interesting paper by the group of Alexander Dömling in Green Chemistry. They used an Ugi four-component reaction followed by product precipitation for the efficient synthesis and purification of a >1200-member acrylamide library.

https://pubs.rsc.org/en/content/articlelanding/2025/gc/d5gc04440e
#CovalentInhibitors #Chemistry #ChemBio

Interesting paper by the group of Alexander Dömling in Green Chemistry. They used an Ugi four-component reaction followed by product precipitation for the efficient synthesis and purification of a >1200-member acrylamide library.

https://pubs.rsc.org/en/content/articlelanding/2025/gc/d5gc04440e
#CovalentInhibitors #Chemistry #ChemBio

Interesting paper by the group of Alexander Dömling in Green Chemistry. They used an Ugi four-component reaction followed by product precipitation for the efficient synthesis and purification of a >1200-member acrylamide library.

https://pubs.rsc.org/en/content/articlelanding/2025/gc/d5gc04440e
#CovalentInhibitors #Chemistry #ChemBio

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202415873
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201915519
#Chemistry #ChemBio #Electrophiles

Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.

https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery

Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.

https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery

Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.

https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery

Exciting talk by Kevin Neumann at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.

https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3548
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202500273
#Chemistry #ChemBio #DrugDiscovery

Great talk by Marta Artola at #NWOCHAINS. She talked about the use of modified sugars as inhibitors and molecular #chaperones in #DrugDiscovery. Exciting insights into the use of cyclic sulfamates and sulfamidates as reactive groups for #CovalentInhibitors.
https://pubs.acs.org/doi/10.1021/acscentsci.7b00214
#Chemistry #ChemBio