#gtpases — Public Fediverse posts

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

The structure of the GDP-bound state of the signal recognition particle-type GTPase FlhF allows comparison with GTP-loaded FlhF and elucidation of the conformational changes associated with GTP hydrolysis @IUCr #FlagellarAssembly #SRPGTPases #GTPases https://doi.org/10.1107/S2053230X24000979

#alt4u
Excerpted from figure legend:

Phylogenetic tree of the McrB #GTPases
The major clades in the #phylogenetic tree of the McrB GTPases are distinguished by the distinct versions of the Nx(xx)D signature motif. Each of the differently colored groups is characterized by distinct conserved genomic associations that are abundant within but not completely confined to the respective groups. This tree was built from the representatives of 90% identity clusters of all validated homologs.

@alexcc