#kinases — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #kinases, aggregated by home.social.
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)
#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology
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Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases -
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases -
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases -
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases -
Interesting J. Med. Chem. paper by the group of Michael Waring. They developed alkynylpyridopyrimidinones that covalently target Cys775 of EGFR to allow development of #CovalentInhibitors even against the C797S resistance mutant.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02924
#Chemistry #ChemBio #DrugDiscovery #Kinases -
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
Protocols All experimental procedures involving mice were carried out in accordance with UK Home Office, Canadian Council on…
#NewsBeep #News #Health #GB #general #Kinases #LifeSciences #Metabolism #Metabolomics #Microbiome #type2diabetes #UK #UnitedKingdom
https://www.newsbeep.com/uk/306460/ -
Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé Farmaceutica in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
https://pubs.acs.org/doi/10.1021/acs.jcim.4c01260
#Chemistry #ChemBio #DrugDiscovery
CC: @LED3hub -
Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé Farmaceutica in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
https://pubs.acs.org/doi/10.1021/acs.jcim.4c01260
#Chemistry #ChemBio #DrugDiscovery
CC: @LED3hub -
Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé Farmaceutica in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
https://pubs.acs.org/doi/10.1021/acs.jcim.4c01260
#Chemistry #ChemBio #DrugDiscovery
CC: @LED3hub -
A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics -
How #plants fend off #pathogens: The role of #calcium and #kinases
#immune_response #agriculture #bacteria #fungi #signalling #bi-kinase_module
https://phys.org/news/2025-01-fend-pathogens-role-calcium-kinases.html
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How #plants fend off #pathogens: The role of #calcium and #kinases
#immune_response #agriculture #bacteria #fungi #signalling #bi-kinase_module
https://phys.org/news/2025-01-fend-pathogens-role-calcium-kinases.html
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How #plants fend off #pathogens: The role of #calcium and #kinases
#immune_response #agriculture #bacteria #fungi #signalling #bi-kinase_module
https://phys.org/news/2025-01-fend-pathogens-role-calcium-kinases.html
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How #plants fend off #pathogens: The role of #calcium and #kinases
#immune_response #agriculture #bacteria #fungi #signalling #bi-kinase_module
https://phys.org/news/2025-01-fend-pathogens-role-calcium-kinases.html
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Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297 -
Allostery in #kinases, a special issue of eLife, including our work on CaMKII.
#biophysics #neuroscience #openaccess
https://elifesciences.org/articles/97084 -
Allostery in #kinases, a special issue of eLife, including our work on CaMKII.
#biophysics #neuroscience #openaccess
https://elifesciences.org/articles/97084 -
Allostery in #kinases, a special issue of eLife, including our work on CaMKII.
#biophysics #neuroscience #openaccess
https://elifesciences.org/articles/97084 -
Allostery in #kinases, a special issue of eLife, including our work on CaMKII.
#biophysics #neuroscience #openaccess
https://elifesciences.org/articles/97084 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064