#kinases — Public Fediverse posts

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé Farmaceutica in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
https://pubs.acs.org/doi/10.1021/acs.jcim.4c01260
#Chemistry #ChemBio #DrugDiscovery
CC: @LED3hub

A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1

#Chemistry #ChemBio #Proteomics #DrugDiscovery #Signalling

Interesting paper by the group of Peter Tonge in JACS. They studied the detailed kinetics of non-covalent BTK inhibitors. Interesting insights that clinical compounds showed increased residence times, while association rates remained nearly constant. https://pubs.acs.org/doi/10.1021/jacs.5c07063
#Kinases #DrugDiscovery #Chemistry #ChemBio #BTK #Kinetics

How #plants fend off #pathogens: The role of #calcium and #kinases

#immune_response #agriculture #bacteria #fungi #signalling #bi-kinase_module

https://phys.org/news/2025-01-fend-pathogens-role-calcium-kinases.html

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

Postdoc - Kinase biology and signalling

Barts Cancer Institute

Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase

See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917

Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic

"two Medicago truncatula cortical cell–specific, #membrane-bound #proteins of a CYCLIN-DEPENDENT KINASE-LIKE (CKL) family associate with, and are #phosphorylation substrates of, DMI2 and a subset of the LysM #receptor #kinases. CKL1 and CKL2 are required for AM #symbiosis and control expression of #transcription factors that regulate part of the #lipid provisioning program. Onset of lipid provisioning is coupled with..the REDUCED ARBUSCULAR #MYCORRHIZA 1 (RAM1) #regulon"

https://www.science.org/doi/10.1126/science.ade1124

Two #Hippo signaling modules converge on the #kinases #LATS1/2 to differentially regulate #YAP/#TAZ activation, orchestrating liver size and #tumorigenesis

Sixian Qi, Zhenxing Zhong, Fa-Xing Yu et al

https://www.embopress.org/doi/10.15252/embj.2022112126