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#mitophagy — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #mitophagy, aggregated by home.social.

  1. The ER membrane protein complex restricts #mitophagy by controlling BNIP3 turnover
    Jose Delgado, Samantha Liu, Christopher Shoemaker et al
    embopress.org/doi/full/10.1038

  2. PhD studentships

    Hebrew University of Jerusalem

    Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

    See the full job description on jobRxiv: jobrxiv.org/job/hebrew-univers

    #ScienceJobs #hiring #research #mitophagy
    Rehovot #Israel #PhD...
    jobrxiv.org/job/hebrew-univers

  3. PhD studentships

    Hebrew University of Jerusalem

    Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

    See the full job description on jobRxiv: jobrxiv.org/job/hebrew-univers

    #ScienceJobs #hiring #research #mitophagy
    Rehovot #Israel #PhD...
    jobrxiv.org/job/hebrew-univers

  4. PhD studentships

    Hebrew University of Jerusalem

    Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

    See the full job description on jobRxiv: jobrxiv.org/job/hebrew-univers

    #ScienceJobs #hiring #research #mitophagy
    Rehovot #Israel #PhD...
    jobrxiv.org/job/hebrew-univers

  5. Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology plos.io/3qfaUZ1

  6. Exploitation of host cell #organelles by an intracellular #pathogen: #Brucella abortus not only uses the ER to replicate, but later also localizes to and fragments #mitochondria to aid bacterial egress via #mitophagy
    Thierry Arnould et al
    embopress.org/doi/10.15252/emb

  7. How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

  8. How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

  9. How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

  10. How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

  11. How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

  12. What controls basal, #Parkin-independent #mitophagy?

    E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

    embopress.org/doi/10.15252/emb

  13. What controls basal, #Parkin-independent #mitophagy?

    E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

    embopress.org/doi/10.15252/emb

  14. What controls basal, #Parkin-independent #mitophagy?

    E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

    embopress.org/doi/10.15252/emb

  15. What controls basal, #Parkin-independent #mitophagy?

    E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

    embopress.org/doi/10.15252/emb

  16. Interesting new paper from Orian Shirihai's group in @embojournal
    "Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
    embopress.org/doi/full/10.1525

    Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast 🎧 👇

    #mitochondria #mitophagy #metabolism

    embo.org/podcasts/fuse-or-die-

  17. How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

    Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

    embopress.org/doi/10.15252/emb

  18. How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

    Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

    embopress.org/doi/10.15252/emb

  19. How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

    Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

    embopress.org/doi/10.15252/emb

  20. How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

    Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

    embopress.org/doi/10.15252/emb

  21. Enhancing #mitophagy promote survival of dopaminergic neurons; @NataliaMoskal3 &co show that effects of Probucol on lipid droplet expansion can augment mitophagy in neurons, improving locomotion in zebrafish & fly models of #ParkinsonsDisease #PLOSBiology plos.io/3IJQM6n