#mitophagy — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mitophagy, aggregated by home.social.
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Fully Funded Postdoc Position in Cancer Research
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/
#BasicdrugDiscovery #cancer #celldeath #mitochondria #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/?fsp_sid=1313 -
Fully Funded Postdoc Position in Cancer Research
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/
#BasicdrugDiscovery #cancer #celldeath #mitochondria #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-postdoc-position-in-cancer-research/?fsp_sid=683 -
Fully Funded PhD Position in Cancer Research
Hebrew University of Jerusalem
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606
#autophagy #cancer_biology #cell_death #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064 -
The ER membrane protein complex restricts #mitophagy by controlling BNIP3 turnover
Jose Delgado, Samantha Liu, Christopher Shoemaker et al
https://www.embopress.org/doi/full/10.1038/s44318-023-00006-z -
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983 -
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172 -
PhD studentships
Hebrew University of Jerusalem
Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165
#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165 -
Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1
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Exploitation of host cell #organelles by an intracellular #pathogen: #Brucella abortus not only uses the ER to replicate, but later also localizes to and fragments #mitochondria to aid bacterial egress via #mitophagy
Thierry Arnould et al
https://www.embopress.org/doi/10.15252/embj.2022112817 -
How are specific dysfunctional #mitochondria removed under steady-state conditions?
Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors
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What controls basal, #Parkin-independent #mitophagy?
E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively
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Interesting new paper from Orian Shirihai's group in @embojournal
"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
https://www.embopress.org/doi/full/10.15252/embj.2022111699Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast 🎧 👇
#mitochondria #mitophagy #metabolism
https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/
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How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?
Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase
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Enhancing #mitophagy promote survival of dopaminergic neurons; @NataliaMoskal3 &co show that effects of Probucol on lipid droplet expansion can augment mitophagy in neurons, improving locomotion in zebrafish & fly models of #ParkinsonsDisease #PLOSBiology https://plos.io/3IJQM6n
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Enhancing #mitophagy promote survival of dopaminergic neurons; @NataliaMoskal3 &co show that effects of Probucol on lipid droplet expansion can augment mitophagy in neurons, improving locomotion in zebrafish & fly models of #ParkinsonsDisease #PLOSBiology https://plos.io/3IJQM6n
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Enhancing #mitophagy promote survival of dopaminergic neurons; @NataliaMoskal3 &co show that effects of Probucol on lipid droplet expansion can augment mitophagy in neurons, improving locomotion in zebrafish & fly models of #ParkinsonsDisease #PLOSBiology https://plos.io/3IJQM6n
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Check out this week's selection of publications on #MembraneContactSites!
http://biomed.news/bims-mecosi/2023-02-05
Thanks to
@Bims_BiomedNews
for the collab! -
For #ThrowbackThursday, an episode of the #EMBOPodcast that aired this summer:
Orian Shirihai tells the story of a classic @embojournal paper on the mitochondrial life cycle.
The episode, "Fuse or Die" highlights the importance of my personal nemesis, the well-organised lab notebook.
#mitochondria #autophagy #NeurodegenerativeDisease #mitophagy #HistoryOfScience
https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/
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Check out our latest poster on the 'Diversity of mitophagy pathways at a glance' by Ian Ganley
and Anne Simonsen. The article is #openaccess thanks to @Co_Biologists #Readandpublish agreement with JISC: https://journals.biologists.com/jcs/article/135/23/jcs259748/285919/Diversity-of-mitophagy-pathways-at-a-glance
#cellbiology #research #openscience #autophagy #mitophagy -
by removing and replacing damaged parts, but on a smaller scale. The different types of maintenance and repair may be part of a continuum, rather than distinct categories.
#Mitophagy and mitochondrial dynamism are two processes that are closely connected. Mitophagy is the process of removing damaged #mitochondria from the #cell, while mitochondrial dynamism is the process of mitochondria fusing together and separating.
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All of these processes help to promote mitophagy and prevent the spread of damage from the damaged mitochondria to the healthy ones.
#PINK1 is a protein that plays an important role in a process called #mitophagy, which is a form of quality control for mitochondria. Mutations in the #PINK1 #gene have been linked to hereditary #Parkinson's disease in humans, but when the PINK1 gene is deleted in mice, it does not cause the same #neurodegenerative pattern seen in humans.
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Mfn2 and PINK1–Parkin Mitophagy Signaling is a mechanism for controlling the quality of #mitochondria in the body. #PINK1 and #Parkin are proteins that are linked to #Parkinson's disease, and mutations in their genes were the first to be identified as causing the disease. Scientists have studied how PINK1 interacts with Parkin, and how this interaction can lead to the destruction of damaged #mitochondria, which is called #mitophagy.
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Three recent papers have also implicated the mitochondrial fission protein Drp1 in cardiac #mitophagy, and it is suggested that if asymmetrical mitochondrial fission normally precedes mitophagy, then chronic suppression of fission by ablating Drp1 would have different consequences on #mitophagy depending on when it is assayed.