#mitochondrial — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mitochondrial, aggregated by home.social.
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Researchers identified the repurposed drug #Sildenafil as a highly promising and effective treatment capable of improving the disease course of Leigh Syndrome, a severe and previously untreatable #mitochondrial disorder affecting brain energy metabolism.
#Neurology #CellBiology #MolecularBiology #Pharmaceutical #sflorg
https://www.sflorg.com/2026/03/cbio03112601.html -
Researchers at Rice University and Baylor College of Medicine utilized a non-editing #CRISPR technique to safely increase #mitochondrial production in heart cells, improving cellular energy levels without causing cellular burnout or malfunction.
#MolecularBiology #Bioengineering #Genetics #sflorg
https://www.sflorg.com/2026/03/mbio03092601.html -
Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html -
Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html -
Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html -
Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html -
Paternal #mitochondrial inheritance is the transmission of mitochondrial DNA from a male parent to its offspring, a biological phenomenon recently proven to occur in plants far more frequently than the traditional paradigm of strict maternal inheritance dictates.
#MolecularPlantPhysiology #Genetics #PlantBiology #Botany #sflorg
https://www.sflorg.com/2026/03/bot03092601.html -
https://www.europesays.com/ch/26014/ NAD+ boosters may also boost gut microbes and beneficial metabolites #CardioProtection #intramuscular #mitochondrial #NadPlus #NAD+ #Nestlé #NeuroProtection #ribosid #supplementation
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#Mitochondrial proteins are synthesized with presequences that target them to the #mitochondrion, but why are some more efficient than others? This study identifies presequences which recruit Hsp90 co-chaperones & TOMM34 to confer prioritized import efficiency @PLOSBiology plos.io/4m6spBN
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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#Fungal infections are hard to treat due to #DrugResistance. @blake_billmyre &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @PLOSBiology https://plos.io/4dz3iVm
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“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
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“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
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“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
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“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
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“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
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“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
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“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
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“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
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SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025
#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun
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SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025
#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun
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“We detailed the genetic, clinical, and molecular profiles of two Han Chinese families with MDD. These families exhibited a range of depression severities and notably low penetrance of MDD. Additionally, distinctive mtDNA polymorphisms associated with haplogroups H2 were identified.” #isogg #dna #mtDNA #mitochondrial #epigenetics #geneadons
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#Space Travel Damages #Astronauts At The Cellular Level
#Mitochondrial damage is causing accelerated a#ging in astronauts and could hamper long-term space missions
The report produced by the Guy Foundation, an independent British research foundation, cited multiple causes behind the cellular damage: #radiation and #zerogravity. While residents on the International Space Station exercise constantly to stave off muscle and bone loss, there’s no workout to help your cells.
https://jalopnik.com/space-travel-is-damaging-astronauts-at-the-cellular-lev-1851692078 -
These findings suggest that elevated FI score of mtDNA variants might contribute to premature aging in young adulthood. (Preprint) #isogg #dna #mitochondrial #mtDNA #haplogroup #aging #geneadons #epigenetics #geneticgenealogy
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#Mitochondrial calcium signaling in #pigmentation: @jyotitanwar1993 @MotianiRaj1 &co show that mito Ca2+ uniporter MCU regulates #melanogenesis by activating NFAT2 & Keratin 5; targeting this axis could be used to treat pigmentary disorders #PLOSBiology https://plos.io/4eswpbV
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#Mitochondrial calcium signaling in #pigmentation: @jyotitanwar1993 @MotianiRaj1 &co show that mito Ca2+ uniporter MCU regulates #melanogenesis by activating NFAT2 & Keratin 5; targeting this axis could be used to treat pigmentary disorders #PLOSBiology https://plos.io/4eswpbV
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#Mitochondrial calcium signaling in #pigmentation: @jyotitanwar1993 @MotianiRaj1 &co show that mito Ca2+ uniporter MCU regulates #melanogenesis by activating NFAT2 & Keratin 5; targeting this axis could be used to treat pigmentary disorders #PLOSBiology https://plos.io/4eswpbV
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#Mitochondrial calcium signaling in #pigmentation: @jyotitanwar1993 @MotianiRaj1 &co show that mito Ca2+ uniporter MCU regulates #melanogenesis by activating NFAT2 & Keratin 5; targeting this axis could be used to treat pigmentary disorders #PLOSBiology https://plos.io/4eswpbV
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#Mitochondrial calcium signaling in #pigmentation: @jyotitanwar1993 @MotianiRaj1 &co show that mito Ca2+ uniporter MCU regulates #melanogenesis by activating NFAT2 & Keratin 5; targeting this axis could be used to treat pigmentary disorders #PLOSBiology https://plos.io/4eswpbV
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Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
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Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
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Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
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Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
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Upregulating #mitochondrial Ca2+ uniporter (MCU) helps #ColorectalCancer cell growth, but what about its regulators? Study shows that MICU2 ensures metabolic flexibility between #glycolysis & #OxPhos and regulates #cancer cell proliferation #PLOSBiology https://plos.io/40pW69s
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New publication from the lab in Methods in Enzymology 📖: A chapter on #massspec based study of #mitochondrial translocation proteins. Free copy available at: https://authors.elsevier.com/a/1jenP_1lc7fPeK
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A price for carrying our endosymbiont? Somatic nuclear #mitochondrial DNA (#Numt) insertions arise spontaneously and accumulate in #brain tissues over the human lifespan @ArthurZhou10 @kalpitark @MitoPsychoBio @ryan_e_mills &co #PLOSBiology https://plos.io/3AyrkAq
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Cell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
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Cell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
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Cell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
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Cell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
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Cell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
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Pam16 & Pam18 are essential for #mitochondrial protein import in eukaryotes, but not in #Trypanosomes. @aschneiderlab show that TbPam16/18 have been repurposed to regulate #replication of #maxicircles within the T. brucei mitochondrial genome #PLOSBiology https://plos.io/3STOEis
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The human gut microbiome
Influences #health and #disease through metabolic, immune, and neurobehavioral pathways. The composition of #gut #microbiota is affected by diet, drugs, and environment.
Athletes can boost performance by optimizing their gut microbiome, which affects mitochondrial health.
#Fiber, polyphenols, and healthy fats boost #microbiome and #mitochondrial function, while ultra-processed foods harm gut health. Fermented foods and #probiotics can restore it.
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#PMAT: Researchers develop a new tool for efficient assembly of #plant #mitochondrial #genomes.
https://phys.org/news/2024-05-pmat-tool-efficient-mitochondrial-genomes.html
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#PMAT: Researchers develop a new tool for efficient assembly of #plant #mitochondrial #genomes.
https://phys.org/news/2024-05-pmat-tool-efficient-mitochondrial-genomes.html
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#PMAT: Researchers develop a new tool for efficient assembly of #plant #mitochondrial #genomes.
https://phys.org/news/2024-05-pmat-tool-efficient-mitochondrial-genomes.html