#mitochondrial — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mitochondrial, aggregated by home.social.
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Researchers at Rice University and Baylor College of Medicine utilized a non-editing #CRISPR technique to safely increase #mitochondrial production in heart cells, improving cellular energy levels without causing cellular burnout or malfunction.
#MolecularBiology #Bioengineering #Genetics #sflorg
https://www.sflorg.com/2026/03/mbio03092601.html -
What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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What is the therapeutic potential of correcting mutations by base editing of the #MitochondrialGenome? This study shows that #mitochondrial #BaseEditing can indeed functionally create & correct mitochondrial pathogenic #mutations in patient-derived cells @PLOSBiology https://plos.io/3ZMa2K2
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#Fungal infections are hard to treat due to #DrugResistance. @blake_billmyre &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @PLOSBiology https://plos.io/4dz3iVm
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“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
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“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
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“We detailed the genetic, clinical, and molecular profiles of two Han Chinese families with MDD. These families exhibited a range of depression severities and notably low penetrance of MDD. Additionally, distinctive mtDNA polymorphisms associated with haplogroups H2 were identified.” #isogg #dna #mtDNA #mitochondrial #epigenetics #geneadons
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#Space Travel Damages #Astronauts At The Cellular Level
#Mitochondrial damage is causing accelerated a#ging in astronauts and could hamper long-term space missions
The report produced by the Guy Foundation, an independent British research foundation, cited multiple causes behind the cellular damage: #radiation and #zerogravity. While residents on the International Space Station exercise constantly to stave off muscle and bone loss, there’s no workout to help your cells.
https://jalopnik.com/space-travel-is-damaging-astronauts-at-the-cellular-lev-1851692078 -
These findings suggest that elevated FI score of mtDNA variants might contribute to premature aging in young adulthood. (Preprint) #isogg #dna #mitochondrial #mtDNA #haplogroup #aging #geneadons #epigenetics #geneticgenealogy
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CW: nature and violence = natural?
@freeschool right, I was talking about the concept of deep time, as described in the Wiki article. The reason for running them together as one word is simply that there's no way to tag phrases as far as I know.
The origin of the post was a conversation I was having elsenet about why modern #humans show evidence of #maternal #inheritance from #Neanderthals via #mitochondrial #DNA, but no evidence of #paternal inheritance via the Y #chromosome.
Their explanation was basically "our ancestors killed all the men and took all the women." Which is possible, of course: there are certainly plenty of examples of that in recorded human #history. But I have hard time believing it's the *only* thing that happened between two species (or subspecies: the line is fuzzy) that interacted with each over over tens and perhaps hundreds of thousands of years.
Another and IMO more likely explanation is that #hybrid #fertility is sex-linked. e.g. the rare #fertile #mules are always female. If the same applied in this case, that would explain why the #Neanderthal Y chromosome disappeared in mixed #human populations.
There are definitely applications to modern behavior. 🙂 But really, I'd mainly just like people to get away from always assuming the bloodiest possible explanation for observed #biological phenomena, whether in humans or any other animal.
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The evolutionary history of plant #plastid & #mitochondrial proteomes reveals that major changes in #organelle biology may have facilitated #plant diversification and the emergence of major lineages such as land plants @Parthkr21 @watertoland #PLOSBiology https://plos.io/3wngsUn
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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Are there specific lipid-based mechanism for shaping inner #mitochondrial #membrane?
Itay Budin, Padmini Rangamani and coworkers at UC San Diego show that #cristae formation is controlled by #cardiolipin and #lipid saturation, in addition to protein-mediated shaping
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"Here, we have addressed the roles of Foxp3+CD4+ regulatory T cells (Tregs) in the healthful activities of #exercise via immunologic, transcriptomic, histologic, metabolic, and #biochemical analyses of acute and chronic exercise models in mice. Exercise rapidly induced expansion of the muscle Treg compartment, thereby guarding against overexuberant production of interferon-γ and consequent #metabolic disruptions, particularly #mitochondrial aberrancies."
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Was Walfänger am Anfang des 20. Jahrhunderts über Bord kippten, haben Genetiker nun untersucht. Ihr Ergebnis: Die Jagd auf die Tiere hat mütterliche Linien ausgelöscht.#Wale #Südgeorgien #Südatlantik #Südhalbkugel #Walfang #Walfänger #Genetik #DNA #Erbgut #mitochondrial #mDNA #KernDNA #Tier #Zoologie #Meeressäuger #Buckelwal #Finnwal #Blauwal #Biologie #ErdeUmwelt
Südgeorgien: Eine Insel übersät mit Walknochen -
Natural killer #NKcell #reprogramming into mature T cells is actively inhibited by the #NuRD complex and #BCL11B-mediated regulation of #H3K27 acetylation - which also inhibit #OPA1-dependent #mitochondrial fusion in #Tcells
Peng Li and collaborators
https://www.embopress.org/doi/full/10.15252/embj.2023113448 -
#Exosomal secretion of #mitochondrial DNA in response to #caspase1 activation promotes #inflammation in Behçet's syndrome
Hyota Takamatsu, Atsushi Kumanogoh and coworkers
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A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress
#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth
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Nucleo-cytoplasmic interaction in seedless cybrid #citrus.
#mitochondrial #genome #chloroplast
https://phys.org/news/2023-07-nucleo-cytoplasmic-interaction-seedless-cybrid-citrus.html
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Nucleo-cytoplasmic interaction in seedless cybrid #citrus.
#mitochondrial #genome #chloroplast
https://phys.org/news/2023-07-nucleo-cytoplasmic-interaction-seedless-cybrid-citrus.html
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#PERK signaling promotes #mitochondrial elongation by remodeling membrane #phosphatidic acid
Luke Wiseman and coworker
https://www.embopress.org/doi/full/10.15252/embj.2023113908 -
MitoQ, a #mitochondrial #antioxidant that is available to the public as a #diet #supplement, was found in a mouse study to reverse the detrimental effects that #HIV and #antiretroviral therapy (#ART) have on mitochondria in the #brain, #heart, #aorta, #lungs, #kidney and #liver.
#Medical #sflorg
https://www.sflorg.com/2023/03/med03242301.html -
Highlighted in issue 6: #Phytosulfokine balancing growth and defense in #plants
Reviews on HIF regulation of #metabolic crosstalk in tumor #microenvironment, and #evolutionary origins of #auxin responses
Further:
Phase separation of #Hippo signalling complexes
#Mitochondrial oxidative stress checkpoint via DNA-PKcs and ATMCover by @tatsuofukagawa1 and colleagues
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How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?
Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase
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Does accumulation of #macromolecules in the highly protein-rich #mitochondrial matrix regulate solute diffusion and biochemical reactions?
Using FRAP analysis of #organelle-targeted fusion peptides, Werner Koopman and colleagues report macromolecular crowding as a stress-dependent determinant of matrix mobility and viscosity -
PhD position: New therapies for the treatment of mitochondrial disease @UCAM
Come join us in #UCAM as a #PhD to work in the field of #Mitochondrial disease
#ScienceJobs #job #Mitochondria
Murcia #Spain #PhDStudent
https://jobrxiv.org/job/universidad-catolica-san-antonio-de-murcia-27778-phd-position-new-therapies-for-the-treatment-of-mitochondrial-disease/?feed_id=37145 -
What is the role of #DNAdamage #kinase #DNAPKcs in the cellular response to #oxidative stress?
Benjamin Chen at UT Southwestern, Hsinyu Lee at National Taiwan University, and coworkers implicate it as part of a #checkpoint that modulates #ANT2-#VDAC2-mediated ADP-ATP exchange over #mitochondrial membranes to limit #OXPHOS-derived ROS
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How to protect cells from excess accumulation of #mitochondrial precursor #proteins in the #cytosol?
Lena Krämer, Johannes Herrmann and collaborators identify #MitoStores - #cytoplasmic storage #granules serving as buffers in #yeast cells upon overwhelmed mitochondrial import -
Can you repeat that?!🌾🍚
#Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both #mitochondrial #RNA splicing and editing and is crucial for #endosperm #development
https://doi.org/10.1111/jipb.13402
@wileyplantsci
#JIPB #PlantScience #AgriTech