#ubiquitination — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ubiquitination, aggregated by home.social.
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#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481 -
Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1
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How are specific dysfunctional #mitochondria removed under steady-state conditions?
Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors
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A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage -
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage -
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage -
A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage -
Surprising interplay between #SMC5/6 and #transcription-regulating #PAF1 complexes in #Arabidopsis #DNAdamage response:
Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for #histone H2B #ubiquitination at DNA double-strand breaks
https://www.embopress.org/doi/10.15252/embj.2022112756 -
Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or inefficient.