#phosphoproteomics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #phosphoproteomics, aggregated by home.social.
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A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
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Our new preprint, presenting PulsPhos, a novel method for proteome-wide measurement of the dynamics of protein phosphorylation at specific sites in living cells, is now out!
This required inventing an elegant strategy for measuring the pool of available phosphates in, which allows us to account for the complex biotransformations of phosphates that occur in intact cells.
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The #phosphoproteomics data also supports the importance of the large exon missing from the 1251 aa exoform.
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#Phosphoproteomics reveal pervasive rewiring of #Cdk1 and Polo kinase phosphorylations during yeast #meiosis, ensuring the occurrence of two successive divisions without intervening S-phase
Lori Koch, Adele Marston et al
https://www.embopress.org/doi/full/10.1038/s44318-024-00059-8
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Estimation of activity changes for >500 kinases & transcription factors in >1,000 cancer samples & cell lines identifies drivers of signalling dysregulation & patient survival ➡️ https://www.embopress.org/doi/full/10.15252/msb.202110631
@pedrobeltrao IMSB ETH
@saezlab UniHeidelberg
@Epetsalaki EMBL-EBI
#CancerGenomics #Genomics #Phosphoproteomics #SystemsBiology -
@edwardlau fantastic, #phosphoproteomics and #transcriptional profiling kinetics of #chromatin remodeling ?
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@seemasainson @J_Cell_Sci @Dev_journal
#integrins, #transcription factors , #cadhedrins, #phosphoproteomics, #glycomics, #biofilm, #quorum receptors, #idiotype, #immnoglobulin subclass swithcing, #immunogenetics, #cytogenetics, #phylogenetics #metabolmics , #reverse vaccinology, etc.?