#d2b — Public Fediverse posts

An interesting article by Jonathan Powell about the power of direct-to-biology approaches in Drug Discovery.

www.linkedin.com/pulse/direct...

#DrugDiscovery #D2B #DirectToBiology #ChemSky #ChemBio

Direct-to-Biology: From Emergi...

An interesting article by Jonathan Powell about the power of direct-to-biology approaches in Drug Discovery.

https://www.linkedin.com/pulse/direct-to-biology-from-emerging-technology-core-drug-discovery-ebjae

#DrugDiscovery #D2B #DirectToBiology

Interesting ChemRxiv preprint by the group of Tom Wennekes with first author Jun Yang Ong. They show that chlorotriazine (ClTriZ) reactive groups are compatible with dual click direct-to-biology (D2B) approaches and can yield potent and selective protein labeling tools.

https://chemrxiv.org/doi/full/10.26434/chemrxiv-2025-4kzhd
#Chemistry #ChemBio #Glycotime #D2B

"Rapid Antibiotic Discovery using a Direct-to-Biology Approach"

Storm van der Voort from the group of Hermen Overkleeft and our group at the @LED3hub presented his exciting research into efficiently finding new antibacterially active #CovalentInhibitors using a direct-to-biology approach and into finding their targets using residue-specific chemoproteomics with the isoDTB-ABPP technology at #NWOCHAINS.

#Bacteria #Antibiotics #Chemistry #ChemBio #ChemicalProteomics #D2B

Interesting paper by the group of Ashraf Brik in JACS. Pd-mediated modification of cyclic peptides allows to combinatorially generate S-arylated derivatives and directly screen them for activity in cells.

https://pubs.acs.org/doi/10.1021/jacs.5c09059
#ChemSky #ChemBio #DirectToBiology #D2B