#targetedproteindegradation — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #targetedproteindegradation, aggregated by home.social.
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Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)
#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success
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Last paper post of the year!
Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.
https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders -
🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?
🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028
📚 CSBJ: https://www.csbj.org/
#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation
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Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91599 -
Research Scientist - Mass spectrometry - Ferguson Lab
University of California, San Diego
Join our team working on #targetedproteindegradation #chemicalproteomics #molecularglues as a mass-spectrometry specialist in the Ferguson lab at UCSD
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scienti...
https://jobrxiv.org/job/university-of-california-san-diego-27778-research-scientist-mass-spectrometry-ferguson-lab/?feed_id=91032 -
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035
#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=52035 -
Postdoctoral Positions in Plant Proteostasis
RWTH Aachen University
Postdoctoral Positions in Plant Proteostasis to study #ubiquitinsignalling #endocytosis #targetedproteindegradation at the @RWTH in the @TrujilloLab
See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851
#Science...
https://jobrxiv.org/job/rwth-aachen-university-27778-postdoctoral-positions-in-plant-proteostasis/?feed_id=50851 -
Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3 -
The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by researchers @abbvie: a #CRISPR screen reveals molecular glue-like recruitment of #DCAF16.
#TargetedProteinDegradation #MonovalentDegraders
https://pubs.acs.org/doi/full/10.1021/acschembio.2c00747 -
https://www.nature.com/articles/s41589-022-01218-w
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. https://pubmed.ncbi.nlm.nih.gov/15039430/ #PROTACs -
An exciting new paper by researchers at Genentech led by Erin Dueber describes a ligase-agnostic #TargetedProteinDegradation platform based on direct 26S proteasome recruitment with macrocyclic PSMD2 ligands! Clever use of the D-enantiomeric macrocycle as an inactive control. These bifunctional ligands deliver target proteins to the 26S proteasome near the AAA+ unfoldase pore, bypassing the requirement for E3 ligase-mediated target ubiquitination prior to degradation!
https://www.nature.com/articles/s41589-022-01218-w -
Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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It's nice to be recognized again this year as a highly cited researcher. I thank the #targetedproteindegradation community for this honor.
#TPD #chemicalbiology -
The eBook of Inducing Targeted Protein Degradation (Ed. Philipp Cromm, published by Wiley-VCH) is now available! Get yours today. Featuring a chapter by me and Erika Araujo. Print edition coming in December. #TPD #TargetedProteinDegradation #PROTAC
https://www.wiley.com/en-gb/Inducing+Targeted+Protein+Degradation%3A+From+Chemical+Biology+to+Drug+Discovery+and+Clinical+Applications-p-9783527350179 -
@Laconde I love this story.#targetedproteindegradation
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Hello mastodon community! A brief intro: I’m a scientist in Eric Fischer’s lab and the Center for Protein Degradation at the Dana-Farber Cancer Institute excited about #targetedproteindegradation #ChemicalBiology and #InducedProximity I’m looking forward to this new experience! #Mastodon