#targetedproteindegradation — Public Fediverse posts

https://www.europesays.com/ch/64124/ C4 Therapeutics Q1 2026 loss $25M, cash $268M #C4Therapeutics #CashBalance #CCCC #cemsidomide #CollaborationRevenue #NetLoss #Q12026 #QuarterlyResults #Roche #RocheDACDeal #TargetedProteinDegradation

Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)

#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success

Last paper post of the year!

Amazing Nature Chemical Biology paper by the group of Christina Woo. PCMT1 installs cyclic imides on asparagines at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.

https://www.nature.com/articles/s41589-025-02106-9
#Chemistry #ChemBio #TPD #TargetedProteinDegradation #Degraders

🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?

🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation

Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3

https://www.nature.com/articles/s41589-022-01218-w
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. https://pubmed.ncbi.nlm.nih.gov/15039430/ #PROTACs

Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson

The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease

...
https://jobrxiv.org/job/university-of-california-san-diego-27778-postdoctoral-fellow-in-medicinal-chemistry-chemical-biology/?feed_id=32868

The eBook of Inducing Targeted Protein Degradation (Ed. Philipp Cromm, published by Wiley-VCH) is now available! Get yours today. Featuring a chapter by me and Erika Araujo. Print edition coming in December. #TPD #TargetedProteinDegradation #PROTAC
https://www.wiley.com/en-gb/Inducing+Targeted+Protein+Degradation%3A+From+Chemical+Biology+to+Drug+Discovery+and+Clinical+Applications-p-9783527350179

Hello mastodon community! A brief intro: I’m a scientist in Eric Fischer’s lab and the Center for Protein Degradation at the Dana-Farber Cancer Institute excited about #targetedproteindegradation #ChemicalBiology and #InducedProximity I’m looking forward to this new experience! #Mastodon

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup