#alzheimerdisease — Public Fediverse posts

Arsenio Paez research into Alzheimer Disease.

https://pubmed.ncbi.nlm.nih.gov/42447420/

#AlzheimerDisease #Demensia #Orexin #Sleep #Cognition #NonREMOscillatoryActivity #NeuralResilience #Research #ArsenioPaez

https://www.iflscience.com/brain-training-that-really-works-first-ever-clinical-proof-that-science-backed-exercises-can-reduce-levels-of-key-alzheimers-marker-84179

#IFLScience #BrainTraining #AlzheimerDisease #ScienceBacked

Il y a quelques jours sortait un rapport de cas pionnier : Amelioration fonctionnelle multidomaine (Rétablissement de la continence urinaire, Amélioration de la mobilité, récupération de la mémoire contextuelle et de travail, augmentation de l’expressivité émotionnelle) d'une patiente atteinte d'Alzheimer apres l'administration de Psilocybine (souche Enigma).

Laissant penser que des capacités fonctionnelles résiduelles persistent dans les stades avancés de la démence et peuvent être temporairement accessibles sous l’effet de la psilocybine.

J'imagine que, dans le futur, cette piste pourrait se coupler à des anticorps anti-amyloïde, par exemple.

#psilocybin #psychedeliques #psilocybine #alzheimerdisease

www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1813281/full

Cc: @denissalem @from_Otterspace @tcrouzet

Even Ars Technica has finally figured it out.

https://arstechnica.com/science/2026/04/whats-the-deal-with-alzheimers-disease-and-amyloid/

"To make matters worse, it turned out that much of that confidence in amyloid-β as the one true cause was built on fake data."

An article in STAT (2019, by Sharon Begley), discussed this. The author of that article passed away, but she was, IMHO, spot on.

https://www.statnews.com/2019/06/25/alzheimers-cabal-thwarted-progress-toward-cure/

(Note that there are folks who disagree with me (and these two aricles). )

https://www.statnews.com/2025/02/14/alzheimers-doctored-charles-piller-amyloid-hypothesis/

#medicine #AlzheimerDisease #science

"Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer’s disease."

"Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells – Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons"
https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/

A press release by the Salk institute on the paper:
"Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids", Currais et al. 2016
https://www.nature.com/articles/npjamd201612

#neuroscience #endocannabinoids #cannabinoids #AlzheimerDisease

Higher B12 Levels Linked to Slower Cognitive Decline

TOPLINE: H…
#NewsBeep #News #Nutrition #Alzheimerdisease;Alzheimer'sdisease;Alzheimer's #biologicalmarker #biomarker #CA #Canada #CVrisk;cardiovascularrisk;CVriskfactors;cardiovascularriskfactors;cardiovascularriskmanagement;CVriskmanagement #Dementia #Health #MBDA #memory #mildcognitiveimpairment;minimalcognitiveimpairment;MCI;mildcognitiveimpairment(MCI) #multi-biomarkerdiseaseactivity #vitamins
https://www.newsbeep.com/ca/270003/

Hola Titánicos cada 21 de septiembre se celebra el día mundial del Alzheimer, este año bajo el lema “El Alzheimer nos afecta a todos”

https://somosdisca.es/dia-mundial-del-alzheimer-2025/

#alzheimer #díamundialdelalzheimer #demencia #AlzheimerDisease #alzheimerjuvenil #alzheimerday #visibilidad #sistemanervioso #cuidados #cuidador #prevencion #dependencia #dependiente #cuidador #salud #enfermedad #enfermedadneurodegenerativa #discapacidad #disabilities #disability #titan #titanicos #titanico #gentetitanica #somosdisca

Mediterranean Diet Cuts Dementia-Linked Metabolites by 35% in APOE4 Carriers

Patients with 2 copies of the APOE4 gene—a major risk factor for Alzheimer disease (AD)—who ate a Mediterranean diet lowered their risk of dementia by 35%, according to study fi…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #alzheimerdisease #APOE4gene #Mediterranean
https://www.diningandcooking.com/2267333/mediterranean-diet-cuts-dementia-linked-metabolites-by-35-in-apoe4-carriers/

Filed under "huge if true":

"Lithium deficiency and the onset of Alzheimer’s disease", Aron et al. 2025
https://www.nature.com/articles/s41586-025-09335-x

#neuroscience #AlzheimerDisease

https://www.europesays.com/uk/356185/ Multidrug Therapy Could Help Both the Heart and the Brain #AlzheimerDisease;Alzheimer'sDisease;Alzheimer's #atherosclerosis #AtheroscleroticDiseaseOfTheCarotidArtery #Blood #brain #CombinationDrugTherapy #ElderCare #elderly #GeriatricMedicine #geriatrics #Health #heart #IncreasedBloodPressure #Lipids;LipidsManagement #Medication #MildCognitiveImpairment;MinimalCognitiveImpairment;MCI;MildCognitiveImpairment(MCI) #OlderAdults #SeniorCitizens #Seniors #UK #UnitedKingdom

Chemotherapy Linked to Brain Atrophy in Breast

Patients with breast cancer who undergo chemotherapy may…
#NewsBeep #News #Health #Alzheimerdisease;Alzheimer'sdisease;Alzheimer's #Brain #breast #breastcancer;malignantbreastneoplasm;breastcarcinoma #CA #Canada #cancer #carcinoma #chemotherapy #cognitiveimpairment #malignantneoplasia #malignantneoplasm #mammarygland #memory #memoryproblems #stroke;cerebrovascularaccident;CVA;cerebrovascularaccident(CVA)
https://www.newsbeep.com/ca/39969/

Chemotherapy Linked to Brain Atrophy in Breast

Patients with breast cancer who undergo chemotherapy …
#NewsBeep #News #Health #Alzheimerdisease;Alzheimer'sdisease;Alzheimer's #AU #Australia #Brain #breast #breastcancer;malignantbreastneoplasm;breastcarcinoma #Cancer #carcinoma #Chemotherapy #cognitiveimpairment #malignantneoplasia #malignantneoplasm #mammarygland #memory #memoryproblems #stroke;cerebrovascularaccident;CVA;cerebrovascularaccident(CVA)
https://www.newsbeep.com/au/38021/

https://www.europesays.com/uk/306857/ All Hype or Some Hope? #AlzheimerDisease;Alzheimer'sDisease;Alzheimer's #brain #cognition #CVRisk;CardiovascularRisk;CVRiskFactors;CardiovascularRiskFactors;CardiovascularRiskManagement;CVRiskManagement #Depression #ElderCare #elderly #GeriatricMedicine #geriatrics #Health #Hypertension #Memory #Nutrition #OlderAdults #SeniorCitizens #Seniors #Stroke;CerebrovascularAccident;CVA;CerebrovascularAccident(CVA) #UK #UnitedKingdom

All Hype or Some Hope?

Media co…
#NewsBeep #News #Nutrition #Alzheimerdisease;Alzheimer'sdisease;Alzheimer's #Brain #cognition #CVrisk;cardiovascularrisk;CVriskfactors;cardiovascularriskfactors;cardiovascularriskmanagement;CVriskmanagement #depression #eldercare #elderly #geriatricmedicine #geriatrics #Health #hypertension #Memory #olderadults #seniorcitizens #seniors #stroke;cerebrovascularaccident;CVA;cerebrovascularaccident(CVA) #UK #UnitedKingdom
https://www.newsbeep.com/uk/35900/

All Hype or Some Hope?

Media consum…
#NewsBeep #News #Nutrition #Alzheimerdisease;Alzheimer'sdisease;Alzheimer's #AU #Australia #Brain #cognition #CVrisk;cardiovascularrisk;CVriskfactors;cardiovascularriskfactors;cardiovascularriskmanagement;CVriskmanagement #depression #eldercare #elderly #geriatricmedicine #geriatrics #Health #hypertension #memory #olderadults #seniorcitizens #seniors #stroke;cerebrovascularaccident;CVA;cerebrovascularaccident(CVA)
https://www.newsbeep.com/au/35056/

https://www.europesays.com/uk/303157/ Combination CVD Meds Tied to Slower Cognitive Decline #AlzheimerDisease;Alzheimer's #antihypertensive #atherosclerosis #AtheroscleroticDiseaseOfTheCarotidArtery #brain #cognition #CVRisk;CardiovascularRisk;CVRiskFactors;CardiovascularRiskFactors;CardiovascularRiskManagement;CVRiskManagement #Dementia #ElderCare #elderly #GeriatricMedicine #geriatrics #Health #Hypertension #Lipids;LipidsManagement #Medication #OlderAdults #SeniorCitizens #Seniors #UK #UnitedKingdom

Doctors’ End-of-Life Choices Break the Norm

A new survey revealed that most doctors wo…
#NewsBeep #News #Healthcare #advancedcancer #Alzheimerdisease;Alzheimer's #assisteddeath #assistedsuicide #CA #Canada #cancer #carcinoma #end-of-lifecare #Health #healthrelatedqualityoflife #hospice/palliativecare #HRQOL #malignantneoplasia #malignantneoplasm #painmanagement #palliativecare #physician-assisteddeath #physician-assistedsuicide #QOL #qualityoflife #stress
https://www.newsbeep.com/ca/33089/

https://www.europesays.com/uk/279983/ The Ethical Minefield of Genetic Testing for All #AlzheimerDisease;Alzheimer's #birth #child #childhood #Children #DNASequence #DNASequencing #ethics #GeneticTesting #Genetics #Genomics;GenomicMedicine #heel #kids #NationalHealthService #neonate #Newborn #NHS #OvarianCancer;MalignantOvarianNeoplasm;OvaryCancer #Pediatrics #PreventiveScreening #Science #screening #UK #UKNationalHealthService #UKNHS #UnitedKingdom #UnitedKingdomNationalHealthService

SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
https://www.science.org/doi/10.1126/sciadv.ads5006

in vitro (ex vivo) work

#Alzheimer #Alzheimers #AlzheimerDisease #SARScov2 #COVID19 #dementia #amyloid

#science #health #medicine #AlzheimerDisease

A study has found that glycogen plays an important part in Alzheimer's Disease. It has previously been ignored as it was known to be stored in liver cells and and muscles. But now it has been found in brain cells in the past where small amounts have been beneficial. However now it is understood that it can accumulate and lead to the production of tau proteins. By breaking the glycogen down it may help to prevent Alzheimer's.
https://www.news-medical.net/news/20250701/Glycogen-metabolism-in-neurons-emerges-as-key-to-fighting-Alzheimers.aspx

Living with Alzheimer's in Ireland

Alzheimer’s: ‘I’ve lost my friend and my companion,’ says Úna Crawford O’Brien of fellow Fair City actor Bryan Murray

https://www.irishtimes.com/health/your-wellness/2025/04/08/alzheimers-ive-lost-my-friend-and-my-companion-says-una-crawford-obrien-of-fellow-fair-city-actor-bryan-murray/

#ireland #health #dementia #alzheimerDisease

Anti-amyloid drug trial shows signs of preventing Alzheimer’s dementia

https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

#AlzheimerDisease #science #medicine

Hola Titánicos cada 21 de septiembre se celebra el día mundial del Alzheimer, este año bajo el lema “Es hora de actuar por la demencia”, un evento instituido por la Organización Mundial de la Salud (OMS).

https://somosdisca.es/dia-mundial-del-alzheimer-2024/

#alzheimer #díamundialdelalzheimer #demencia #AlzheimerDisease #alzheimerjuvenile #alzheimerday #visibilidad #cuidados #dependencia #dependiente #cuidador #salud #enfermedad #enfermedadneurodegenerativa #discapacidad #disabilities #disability #titan #titanicos #titanico #gentetitanica #somosdisca

The #BloodBrainBarrier, a network of blood vessels and tissues that nurtures and protects the brain from harmful substances circulating in the blood—is disrupted in #AlzheimerDisease. Now, researchers at #MayoClinic and collaborators have uncovered unique #molecular signatures of blood-brain barrier #dysfunction that could point to new ways to diagnose and treat the disease. Their findings are published in Nature Communications.
https://medicalxpress.com/news/2024-06-vascular-brain-linked-alzheimer-disease.html #healthcare #publichealth #dementia

#JeffersonCenter for #Healthy #Aging opens #clinic for #LGBTQ+ #elders in #Philly.

All the #doctors at the #clinic are #geriatricians and base their care on the #4Ms #model: what #matters, #medication, #mentation and #mobility

#Mentation has to do with the #prevention and #treatment of #AlzheimerDisease and #Dementia.

#Women #Transgender #LGBTQ #LGBTQIA #Pennsylvania #Aging #Health #Healthcare

https://epgn.com/2023/10/25/jefferson-opens-clinic-for-lgbtq-older-adults-in-philly/

The Grenon family behind the faux "church" producing and marketing the poisonous MMS (Miracle Mineral Solution) are in court in Miami this week. MMS is a quack treatment for #HIV/#AIDS, #autism, #AlzheimerDisease, #COVID19, #leukemia and other conditions.
The Genesis II "church" and MMS quacks also operate in #Ireland.
https://www.miamiherald.com/news/state/florida/article277293398.html

I’ve absolutely loved “How Not to Study a Disease: The Story of Alzheimer’s” by Prof. Karl Herrup, so if you’d like to read a bit more in-depth about that, check out my latest post:

https://neurofrontiers.blog/book-review-how-not-to-study-a-disease/

#BookReview #alzheimer #Alzheimers #ScienceBook #AlzheimerDisease #science

Older adults with dementia but without close family: Who are they? And who cares for them?
#Health #Dementia #Family #Aging #Families #Caregiving #Seniors #Caregivers #Alzheimer #AlzheimerDisease
https://the-14.com/older-adults-with-dementia-but-without-close-family-who-are-they-and-who-cares-for-them/

New paper from the group of Mark Hipp (UMCG #Groningen) and collaborators: "The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system" About chaperones, disaggregases, #amyloid and more. Notes that fibril disaggregation can actually enhance #prion like spreading....
https://www.nature.com/articles/s41467-023-36058-2 #AlzheimerDisease

A few long form pieces outside my area of expertise: this on #AlzheimerDisease in #QuantaMagazine I found extremely interesting and also heartbreaking - it's a very complex disease and there is much scientific uncertainty around the causes. Worth a read: https://www.quantamagazine.org/what-causes-alzheimers-scientists-are-rethinking-the-answer-20221208/

Study Shows New Blood Test Can Detect 'Toxic' Protein Years Before Alzheimer's Symptoms Emerge

https://www.sciencedaily.com/releases/2022/12/221205153722.htm

#microbiology #immunology #molecularbiology #alzheimers #alzheimerdisease