#proteinfolding — Public Fediverse posts

How Octopuses Hacked their Ribosome to Become Smart

https://fed.brid.gy/r/https://hackaday.com/2026/07/17/how-octopuses-hacked-their-ribosome-to-become-smart/

How Octopuses Hacked their Ribosome to Become Smart

https://web.brid.gy/r/https://hackaday.com/2026/07/17/how-octopuses-hacked-their-ribosome-to-become-smart/

New blog: AI-Designed Drugs — Accelerating Discovery with Protein Folding & Simulation. Discover how AI-driven protein folding and advanced chemical simulation are cutting discovery timelines, improving candidate quality, and enabling more efficient R&D. Read the article: https://wix.to/rJUJMx8

#AI
#Biotech
#Innovation
#DrugDiscovery
#ProteinFolding
#Pharmaceuticals
#ComputationalChemistry

New blog: AI-Designed Drugs — Accelerating Discovery with Protein Folding & Simulation. Discover how AI-driven protein folding and advanced chemical simulation are cutting discovery timelines, improving candidate quality, and enabling more efficient R&D. Read the article: https://wix.to/rJUJMx8

#AI
#Biotech
#Innovation
#DrugDiscovery
#ProteinFolding
#Pharmaceuticals
#ComputationalChemistry

Glutathione's Hidden Hand in Protein Assembly Revealed

Researchers found glutathione helps cells make proteins. This could help fight diseases like cancer. Learn what changes for cell health.

#CellBiology, #ProteinFolding, #Glutathione, #DiseaseResearch, #RockefellerUniversity

https://newsletter.tf/glutathione-helps-cells-make-proteins-correctly/

Scientists discovered a new job for glutathione in cells. It's like a supervisor making sure proteins are built right, which is more specific than just being an antioxidant.

#CellBiology, #ProteinFolding, #Glutathione, #DiseaseResearch, #RockefellerUniversity
https://newsletter.tf/glutathione-helps-cells-make-proteins-correctly/

#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife https://mastodon.social/@biohackingpathway/116342357588783749

#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife https://mastodon.social/@biohackingpathway/116342357588783749

Pipeline release! nf-core/proteinfold v2.0.0 - Montseny Brook Newt!
Protein 3D structure prediction pipeline
Please see the changelog: https://github.com/nf-core/proteinfold/releases/tag/2.0.0

#alphafold2 #colabfold #esmfold #proteinfoldprediction #proteinfolding #proteinsequences #proteinstructure #nfcore #openscience #nextflow #bioinformatics

Pipeline release! nf-core/proteinfold v2.0.0 - Montseny Brook Newt!
Protein 3D structure prediction pipeline
Please see the changelog: https://github.com/nf-core/proteinfold/releases/tag/2.0.0

#alphafold2 #colabfold #esmfold #proteinfoldprediction #proteinfolding #proteinsequences #proteinstructure #nfcore #openscience #nextflow #bioinformatics

`Surprisingly..extracted diffusion coefficient at the free energy barrier on the number of native contacts coordinate increases with protein length. This facilitation..in larger proteins is explained by increased cooperative native contact formation during folding, which reduces the roughness of the energy landscape... evolutionary optimization of the energy landscape..more efficient for protein folding than for other biomolecular processes`
https://doi.org/10.1103/2q9m-4scc
#proteinFolding #biophysics

`Surprisingly..extracted diffusion coefficient at the free energy barrier on the number of native contacts coordinate increases with protein length. This facilitation..in larger proteins is explained by increased cooperative native contact formation during folding, which reduces the roughness of the energy landscape... evolutionary optimization of the energy landscape..more efficient for protein folding than for other biomolecular processes`
https://doi.org/10.1103/2q9m-4scc
#proteinFolding #biophysics

From child prodigy to a race to be the one that puts humans in a zoo. Great look into our current trajectory. Who will wield the stick?

https://www.tribecafilm.com/films/thinking-game-2024

https://youtu.be/d95J8yzvjbQ

#DemisHassabis #AGI #AI #LLM #DeepMind #Google #Geopolitics #ProteinFolding #Science #ThinkingGame #MachineLearning #Energy

From child prodigy to a race to be the one that puts humans in a zoo. Great look into our current trajectory. Who will wield the stick?

https://www.tribecafilm.com/films/thinking-game-2024

https://youtu.be/d95J8yzvjbQ

#DemisHassabis #AGI #AI #LLM #DeepMind #Google #Geopolitics #ProteinFolding #Science #ThinkingGame #MachineLearning #Energy

When Google restricted AlphaFold 3's commercial use, three MIT PhD students rebuilt the protein folding model in four months. Their open-source version, Boltz-1, now has $28M in funding and a Pfizer partnership. The move highlights tensions between proprietary AI research and scientific openness in drug discovery infrastructure. #OpenScience #ProteinFolding #AIResearch https://www.implicator.ai/when-google-locked-the-door-three-mit-students-picked-the-lock/

When Google restricted AlphaFold 3's commercial use, three MIT PhD students rebuilt the protein folding model in four months. Their open-source version, Boltz-1, now has $28M in funding and a Pfizer partnership. The move highlights tensions between proprietary AI research and scientific openness in drug discovery infrastructure. #OpenScience #ProteinFolding #AIResearch https://www.implicator.ai/when-google-locked-the-door-three-mit-students-picked-the-lock/

Five years after AlphaFold reshaped protein folding, its open‑source spirit lives on in Gemini 2.0 – an AI co‑scientist that can argue hypotheses with a principal investigator. Could an agentic system become a true research partner? Dive into the debate and see how open science fuels the next leap. #AlphaFold #Gemini2 #AgenticSystem #ProteinFolding

🔗 https://aidailypost.com/news/alphafold-marks-5-years-new-gemini-20-ai-coscientist-debates

Why proteins fold and how GPUs help us fold

https://aval.bearblog.dev/nvidiaproteins/

#HackerNews #proteinfolding #GPUs #science #technology #research

Why proteins fold and how GPUs help us fold

https://aval.bearblog.dev/nvidiaproteins/

#HackerNews #proteinfolding #GPUs #science #technology #research

AlphaFold - The Single Most Important AI Breakthrough

https://www.youtube.com/watch?v=Vhcwjzeukts

#AlphaFold #AI #ML #MachineLearning #TwoMinutePapers #Google #DeepMind #Biology #ProteinFolding #Science #NobelPrize

AlphaFold - The Single Most Important AI Breakthrough

https://www.youtube.com/watch?v=Vhcwjzeukts

#AlphaFold #AI #ML #MachineLearning #TwoMinutePapers #Google #DeepMind #Biology #ProteinFolding #Science #NobelPrize

🧬 Can salt levels change how cell-penetrating peptides behave at membranes?

🔗 Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.004

📚 CSBJ: https://www.csbj.org/

#MolecularDynamics #PeptideAggregation #MembraneProtein #Biophysics #StructuralBiology #ProteinFolding #MembraneBiology

🧬 Can salt levels change how cell-penetrating peptides behave at membranes?

🔗 Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.004

📚 CSBJ: https://www.csbj.org/

#MolecularDynamics #PeptideAggregation #MembraneProtein #Biophysics #StructuralBiology #ProteinFolding #MembraneBiology

🧬 How do changes in a non-catalytic residue collapse an entire enzyme’s function?

🔗 Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.014

📚 CSBJ: https://www.csbj.org/

#Biophysics #Enzymology #StructuralBiology #Mutations #ProteinFolding

🧬 How do changes in a non-catalytic residue collapse an entire enzyme’s function?

🔗 Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.014

📚 CSBJ: https://www.csbj.org/

#Biophysics #Enzymology #StructuralBiology #Mutations #ProteinFolding

SimpleFold: Folding Proteins Is Simpler Than You Think

https://github.com/apple/ml-simplefold

#HackerNews #SimpleFold #Folding #Proteins #AI #Research #Bioinformatics #ProteinFolding #GitHub

SimpleFold: Folding Proteins Is Simpler Than You Think

https://github.com/apple/ml-simplefold

#HackerNews #SimpleFold #Folding #Proteins #AI #Research #Bioinformatics #ProteinFolding #GitHub

💥 Революция в биохимии! ИИ научился предсказывать и даже создавать белки 🧬. AlphaFold и Rosetta меняют всё: от медицины до экологии. Это начало новой эры в науке! 🔬🤖 #AlphaFold #ИИ #биохимия #наука #технологии #NobelPrize #AI #биотех #proteinfolding #DeepMind

Подробнее: https://scientia-et-innovatio.blogspot.com/2025/05/blog-post.html

Dr. Ali Hassanali from the Abdus Salam International Centre for Theoretical Physics (ICTP) is back with a new lecture! This time, Ali discusses the role of amide bonds and dipole moments in the dynamics and stability of protein folding. He investigates how amino acid sequences transform from unfolded to folded states, emphasizing the various interactions that play a crucial role in this fundamental biological process.

🎥 You can access this hashtag#OpenAccess lecture for free on Enabla and engage in meaningful online discussions with Dr. Hassanali and the Enabla community regarding protein folding dynamics and stability: https://enabla.com/pub/1024/about

This is a fantastic opportunity to expand your understanding of protein structure and the factors influencing it, including external conditions like pH and temperature, as well as the impact of post-translational modifications.

#Biophysics #ProteinFolding #MolecularBiology #OpenScience #AminoAcids

👨‍🔬🔍 Apparently, the secret to protein folding was hiding in the 400 Bad Request error all along! Who knew server security policies were the key to solving scientific mysteries? 🧪🔒
https://phys.org/news/2025-03-protein-mystery-core-fractions.html #proteinfolding #serversecurity #scientificbreakthrough #400BadRequest #technologynews #HackerNews #ngated

👨‍🔬🔍 Apparently, the secret to protein folding was hiding in the 400 Bad Request error all along! Who knew server security policies were the key to solving scientific mysteries? 🧪🔒
https://phys.org/news/2025-03-protein-mystery-core-fractions.html #proteinfolding #serversecurity #scientificbreakthrough #400BadRequest #technologynews #HackerNews #ngated

A protein folding mystery solved: Study explains core packing fractions

https://phys.org/news/2025-03-protein-mystery-core-fractions.html

#HackerNews #proteinfolding #science #research #corepacking #fractions #mysterysolved

A protein folding mystery solved: Study explains core packing fractions

https://phys.org/news/2025-03-protein-mystery-core-fractions.html

#HackerNews #proteinfolding #science #research #corepacking #fractions #mysterysolved

https://youtube.com/watch?v=P_fHJIYENdI&si=ECF7pagdnAgEwT4Z

Veritasium just released a great video of #ProteinFolding algorithms and #AlphaFold as part of the story.

The Veritasium team releases some of the best science videos around: accessible, clear and accurate. It's a great service to communicate this breakthrough to everyone.

#ScientificComputing #Bioinformatics #AI #MachineLearning #ScienceCommunication #ProteinDesign

P.S. shame about the anthropomorphic hype at the end

https://youtube.com/watch?v=P_fHJIYENdI&si=ECF7pagdnAgEwT4Z

Veritasium just released a great video of #ProteinFolding algorithms and #AlphaFold as part of the story.

The Veritasium team releases some of the best science videos around: accessible, clear and accurate. It's a great service to communicate this breakthrough to everyone.

#ScientificComputing #Bioinformatics #AI #MachineLearning #ScienceCommunication #ProteinDesign

P.S. shame about the anthropomorphic hype at the end

On this note: are you interested in #tech, #selfHosting, #science, #computationalScience, #HPC, #liberatoryTech, or just #POSIX in general but otherwise lack the resources, financial or otherwise? Get in touch with me and we can have a chat about maybe getting you some time. I can't promise when things will be ready or how much I can offer, but.

No generative AI training, please. 'Classic' ML that doesn't generate trash, contribute to surveillance, or rely on stolen data is fine though.

EDIT: please feel free to boost! DMs for initial contact are fine; while I run my server, I do not run yours so just a hello and a general area of interest are all I ask that you put in there. If you feel a project or interest is sensitive we can arrange another chat medium from there. I just wanna get a sense of who you are since I'll be, you know, letting you access the computer sitting in my office lmao.

EDIT 2: I can also specifically help to some degree if you're interested in learning about #computationalChemistry, #proteinFolding, or running a few different types of #simulations.

EDIT 3: If you're interested in writing/deploying/understanding #webDesign, #webTech, etc, that's also possible. I'm not trying to limit anything here, mostly just tagging with what things I know.

EDIT 4: jesus christ Audrey. Anyway, "a sense of who you are" does NOT have to include personally identifying information. I mean much more informal and useful stuff than that, such as what you're interested in and wanna work on. I want you to get to know me a little bit, too, because we'll both need a degree of trust and if you feel you can't trust me then please don't force yourself to.

RE: https://fire.asta.lgbt/notes/a3911f2wi43200mf

On this note: are you interested in #tech, #selfHosting, #science, #computationalScience, #HPC, #liberatoryTech, or just #POSIX in general but otherwise lack the resources, financial or otherwise? Get in touch with me and we can have a chat about maybe getting you some time. I can't promise when things will be ready or how much I can offer, but.

No generative AI training, please. 'Classic' ML that doesn't generate trash, contribute to surveillance, or rely on stolen data is fine though.

EDIT: please feel free to boost! DMs for initial contact are fine; while I run my server, I do not run yours so just a hello and a general area of interest are all I ask that you put in there. If you feel a project or interest is sensitive we can arrange another chat medium from there. I just wanna get a sense of who you are since I'll be, you know, letting you access the computer sitting in my office lmao.

EDIT 2: I can also specifically help to some degree if you're interested in learning about #computationalChemistry, #proteinFolding, or running a few different types of #simulations.

EDIT 3: If you're interested in writing/deploying/understanding #webDesign, #webTech, etc, that's also possible. I'm not trying to limit anything here, mostly just tagging with what things I know.

EDIT 4: jesus christ Audrey. Anyway, "a sense of who you are" does NOT have to include personally identifying information. I mean much more informal and useful stuff than that, such as what you're interested in and wanna work on. I want you to get to know me a little bit, too, because we'll both need a degree of trust and if you feel you can't trust me then please don't force yourself to.

RE: https://fire.asta.lgbt/notes/a3911f2wi43200mf

#TerrenceDeacon - #Philosophy of #Biological #Information

https://www.youtube.com/watch?v=KH5p7uFMr3c

#PhilosophyOfBiology #Biology #PhilosophyOfScience #Science #Shannon #Signal #Signals #Complexity #Encoding #DNA #Protein #Chemistry #Folding #ProteinFolding #Evolution #EvolutionaryBiology #CloserToTruth #RobertKuhn

#TerrenceDeacon - #Philosophy of #Biological #Information

https://www.youtube.com/watch?v=KH5p7uFMr3c

#PhilosophyOfBiology #Biology #PhilosophyOfScience #Science #Shannon #Signal #Signals #Complexity #Encoding #DNA #Protein #Chemistry #Folding #ProteinFolding #Evolution #EvolutionaryBiology #CloserToTruth #RobertKuhn

Nobel Prize in Chemistry 2024:

David Baker, USA, is honored for his work in computational protein design,

the other half is shared by Demis Hassabis and John M. Jumper, both UK, for their contributions to protein structure prediction

https://www.chemistryviews.org/nobel-prize-in-chemistry-2024/

#chemistry #chemistryviews #chemviews #chemiverse #nobelprize2024 #2024nobelprize #chemistrynobelprize #nobelprizeinchemistry #proteinfolding #biochemistry #ai

Nobel Prize in Chemistry 2024:

David Baker, USA, is honored for his work in computational protein design,

the other half is shared by Demis Hassabis and John M. Jumper, both UK, for their contributions to protein structure prediction

https://www.chemistryviews.org/nobel-prize-in-chemistry-2024/

#chemistry #chemistryviews #chemviews #chemiverse #nobelprize2024 #2024nobelprize #chemistrynobelprize #nobelprizeinchemistry #proteinfolding #biochemistry #ai

Biologists are so ridiculous. They’re folding proteins, and they’re telling you they need supercomputers for that. I’ll have you know I just folded a fitted sheet, with my bare hands. #Biology #ProteinFolding

Biologists are so ridiculous. They’re folding proteins, and they’re telling you they need supercomputers for that. I’ll have you know I just folded a fitted sheet, with my bare hands. #Biology #ProteinFolding

#AlanLove - #PhilosophyOfMolecularBiology & #Genes

https://www.youtube.com/watch?v=btP7EFuVxxs

#Philosophy #PhilosophyOfBiology #Biology #PhilosophyOfScience #Science #Genetics #Evolution #Gene #Classification #Protein #Proteins #ProteinFolding #AlphaFold #SideEffects #CloserToTruth #RobertKuhn

#AlanLove - #PhilosophyOfMolecularBiology & #Genes

https://www.youtube.com/watch?v=btP7EFuVxxs

#Philosophy #PhilosophyOfBiology #Biology #PhilosophyOfScience #Science #Genetics #Evolution #Gene #Classification #Protein #Proteins #ProteinFolding #AlphaFold #SideEffects #CloserToTruth #RobertKuhn

3-JUL-2024
Do genes-in-pieces code for proteins that fold in pieces?

https://www.eurekalert.org/news-releases/1050362
the method used is called #FrustrationAnalysis - I like that.
#science #ProteinFolding #nanoworld

3-JUL-2024
Do genes-in-pieces code for proteins that fold in pieces?

https://www.eurekalert.org/news-releases/1050362
the method used is called #FrustrationAnalysis - I like that.
#science #ProteinFolding #nanoworld

"This is the story of how Jumper’s team at Google DeepMind pulled off their coup in protein science, and what it means for the future of artificial intelligence in biology."

https://www.quantamagazine.org/how-ai-revolutionized-protein-science-but-didnt-end-it-20240626/

#MachineLearning #Biology #Proteins #GoogleDeepMind #ProteinFolding

"This is the story of how Jumper’s team at Google DeepMind pulled off their coup in protein science, and what it means for the future of artificial intelligence in biology."

https://www.quantamagazine.org/how-ai-revolutionized-protein-science-but-didnt-end-it-20240626/

#MachineLearning #Biology #Proteins #GoogleDeepMind #ProteinFolding

Insights into Alzheimer’s disease from single-cell genomic approaches

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #BrainAging #Aging #BrainDiseases #Brain #Neurodegeneration #Alzheimer
#Neuroinflammation #Inflammation #ImmuneResponse #MetabolicStress #ProteinFolding #Lipid #LipidSignaling #LipidMetabolism #Metabolism #DNAdamage #CellSenescence #Senescence #VascularCells #Vascular

https://www.nature.com/articles/s41593-022-01222-2