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13 results for “mice”
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https://www.europesays.com/ie/745706/ Needle-free mRNA vaccines protect mice against COVID-19 and flu #cancer #Covid19 #Éire #flu #IE #ImmuneResponse #immunity #inflammation #Ireland #Laboratory #MedicalResearch #MedicalSchool #Protein #Research #skin #Technology #Vaccine
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Carved pumpkins for Halloween are cute and all but be warned…
This Halloween, millions of households around the world will forsake plastic pumpkins for the real thing – especially in the U.S. where carving pumpkins has become somewhat of a pastime during Fall.
While it is Spring in Australia when Halloween hits, we do have pumpkins available for decoration, carving, etcetera, and you’ll find certain decoration fanatics do insist on carving the real thing. If so, do consider that ‘open’ pumpkins often attract pests, such as spiders, flies, and even mice.
Decaying pumpkins can be a major attraction for fruit flies as well as squash bugs, which could result in infestation that can be particularly difficult to rectify.
Here are a few tips to keep these pesty buggers away if carving a pumpkin is on your to-do list this year.
Keep pumpkins off the ground and elevated
Putting your pumpkins on raised platforms such as tables helps to limit moisture, which if present, can attract numerous pests.Clean the pumpkin thoroughly as well as cleaning any other attractants
Take care to remove all the seeds and pulp inside of the pumpkin, as this will aid in slowing down the decay of the pumpkin which attracts pests. Additionally, be sure to remove other potential food sources, such as sweets that may be left outside, to avoid additional sources of attraction for pests.Use natural pest deterrents
Cupboard staples such as spices can be natural deterrents for pests. Cayenne pepper or cinnamon for example, can be sprinkled onto the pumpkins interior and exterior to keep pests at bay.Consider using alternatives
Artificial pumpkins can be a great way to decorate for Halloween and get in the spooky spirit even if they usually end up in landfill. At least you’ll be without the risk of attracting pests. And if the landfill bit offends, try using your placcy pumpkin more than once – or better still, get a pumpkin made of ceramic, which is much better for the environment!********
Going Bananas: we’re seeing a lot of this fabulous ingredient around this season
That Magical Ingredient: haircare that delivers excellent results thanks to key natural ingredients
A tribute to Emilio Pucci: the designer who practically invented lifestyle
Great Tech and Lifestyle Upgrades for a Seamless Overseas Holiday
Australian Museum set to turn time waaaay back with mammoth dinosaur exhibition opening in November
Bedtime Stories: Let’s get adventurous, honey, let’s get adventurous
#CREAMMAGAZINE #halloween #howToCarveAPumpkin #POPCULTURE #pumpkinCarving -
In many parts of Africa, the Woodland Kingfisher’s (Halcyon senegalensis) arrival coincides with the onset of the rains, making it a familiar seasonal herald.
This species spends surprisingly little time fishing, hunting mainly large insects, as well as small lizards, frogs, and occasionally mice.
They typically perch quietly on an exposed branch or wire, then swoop down to seize prey on the ground.
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DATE: October 23, 2026 at 04:28AM
SOURCE: SCIENCE DAILY PSYCHOLOGY FEEDTITLE: Scientists discover a hidden messaging system deep inside the brain
URL: https://www.sciencedaily.com/releases/2026/10/261022081304.htm
A tiny region deep within the brain has surprised scientists by revealing a remarkably sophisticated communication system. Previously thought to broadcast the same chemical signal throughout the brain, this region actually sends targeted messages that help control learning, attention, and behavior, according to new research in mice.
URL: https://www.sciencedaily.com/releases/2026/10/261022081304.htm
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DATE: October 23, 2026 at 04:28AM
SOURCE: SCIENCE DAILY MIND-BRAIN FEEDTITLE: Scientists discover a hidden messaging system deep inside the brain
URL: https://www.sciencedaily.com/releases/2026/10/261022081304.htm
A tiny region deep within the brain has surprised scientists by revealing a remarkably sophisticated communication system. Previously thought to broadcast the same chemical signal throughout the brain, this region actually sends targeted messages that help control learning, attention, and behavior, according to new research in mice.
URL: https://www.sciencedaily.com/releases/2026/10/261022081304.htm
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TAP Air Portugal has received the awards for Best European Airline to Africa and Best European Airline to South America at the 2026 World Travel Awards.
TAP was also named European Airline with the Best Website at the 2026 World Travel Tech Awards.
At the same ceremony, the organisation presented the 2026 MICE Awards. TAP was voted Best European Airline.
https://www.paullotravel.com/tap-air-portugal-best-european-airline-africa-south-america-2026/
#tapairportugal #worldtravelawards #worldtraveltechawads #travel #2026besteuropeanairline #redbirdtravelnews
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:neomouse_color_fawn: AussieKitten ┇🔜 Cheddar Plushies | Art Comms CLOSED | YCH's OPEN @[email protected]Two year marriage anniversary with Rennick
Happy 2 years Rennick ❤️You are my entire world, you are my rock and I dunno what I'd do without you 🥹
Best two years of my life hands down, it's been so amazing being able to live together and wake up next to eachother everyday. You complete me 🥹❤️
#art #furry #furryfandom #furryartist #furryart #furryfyp #artwork #digitalart #digitalartist #illustration #anthro #animal #commsopen #mice #mouse #love #marriage -
New Take On Controversial TTRPG Companies.
I don’t think I’ve heard anyone say it yet.
This week has been another quiet news week around the TTRPG world and thank goodness for that. Wizards of the Coast employees continue to whine and beg for a union. Hasbro’s Q3 numbers came out. Yawn.
Chaosium, makers of Call of Cthulhu decided to start retroactively sanitizing some of the scary bigoted stuff out of their old products. Should I care? I mean, it’s their product to do with what they will, right?
So here’s my controversial take. Ready? If a TTRPG company is going to fail, LET THEM!
Let. Them. Fail.
I mean, honestly, if WotC employees fail to unionize, that’s on them. If Hasbro starts firing people left, center, and right, cool. Isn’t that what a lot of us have been wanting for years now? Aren’t they the ones everyone has been complaining about for the last three years minimum? I hope Tondro and Makenzie will be the first ones out the door. (I’m not worried about them finding employment elsewhere with their “impeccable” credentials.)
If WotC employees unionize successfully and get their way with Hasbro, okay. Great. When their next several products bomb, which they probably will anyway, it just looks bad on the people it always looks bad on. Hasbro’s Q3 numbers were far from a conversation starter. Dungeons & Dragons never came up as far as I know.
If WotC/Hasbro self-destruct, the fans win. If they suddenly figure out how to not make D&D suck out loud, the fans win. One way or another it’s going to be okay.
If Chaosium loses its older fanbase and fails to recover, yes we’ll be sad. I happen to like Call of Cthulhu and Basic RolePlaying Game (BRP.) It’s not like my copies of those games are going to spontaneously evaporate. Players will still connect. The reprints will still be around for a while. No big, really.
Alternatively, if Chaosium doubles down on proving they’re still a good company, that makes their games that much more appealing. If Chaosium caves to the angry old men complaining about censorship and goes back to the older printings of things they sanitized, that’s okay too.
Back in my day we had this saying that y’all kids don’t understand: If you find it offensive, don’t buy it.
I’m not worried about it one way or another. You’re going to do whatever you see fit no matter what some crotchety old fartz on the Internet try to say. Your mind will be made up one way or another. Do what you think is best. I literally say it all the time.
I haven’t picked up a single official D&D release in three years now. However, I’ve discovered my new forever game, Dragonbane in that time. I also found a rising star in Two Little Mice as a company with both the Outgunned line and Twilight Sword. I have a game for almost every occasion, mood, or scenario.
And get this—any game I don’t have on hand, I will simply create for myself. It’s not that hard. Anyone can do it. Will it ever be printed? Maybe not. It might never leave my notebooks. It might end up on my blog. It could eventually land on DriveThruRPG.com.
I still have my entire ICONS setting in handwritten notes. There are still plenty of untapped resources in terms of game systems, settings, and supplements on my shelves or pdf. I’ve pretty much come to the conclusion that no matter what happens, I’m never going to get tired of TTRPGs. I’ll be doing this until I’m 103 years old.
That’s also why I’m turning a little more toward solo gaming now. Twilight Sword is my dream variant on Final Fantasy. It’s also everything I love about TTJRPGs and anime/manga games. The monster book coming to BackerKit in November makes me even more hungry for official Twilight Sword content. What I do in my solo content may just stay with me, for fun, for my own enjoyment. Alternatively it could end up being on the blog here or DriveThruRPG.
What I’m getting at with all this is we always have a choice. I’m just choosing to focus my energy back on things I care about and let the big companies do whatever they’re going to do. Until official D&D in particular gets back into my crosshairs somehow, I don’t care what WotC does or doesn’t do. I’m just going to break out the popcorn and laugh at them.
I say it every year, but I think 2026 bears repeating it. This year I intend to write more, read more, and discuss cool TTRPGs as well as supplements. Most of all, let’s just have more fun. Let’s explore. Let’s save the kingdom from the evil warlord. Let’s discuss all the fun stuff in gaming that we love.
With the world in the state it finds itself in today, please be kind. Please be considerate to one another even if we don’t agree. Lastly, please pursue the thing that brings you the most joy without harm to others. Thank you!
#BringbackDnD #BringbackgoodDnD #DD #Dnd #DnD2024 #Dnd5E #Dnd5Eblog #Dnd5Eblogger #DnDBeGone #DnDBeyond #Dndblog #Dndblogger #Dndcommunity #DndDM #DungeonsDragons #DungeonsnDragons #Equality #Fantasy #FreeDnD #GetMakenzieOut #Hadozee #OpenDnD #Rpg #Rpgblog #Rpgblogger #Rpgwriter #Ttrpg #TTRPGblog #TTRPGblogger #Ttrpgdesign #Ttrpgwriter #Wizardsofthecoast #Wotc #WotCArt #Wotcconspiracies #Wotcsucks #DnDBeyond #WizardsDnD #D #DnDBeyond #DONTbringbackDarkSun #gaming #GetMakenzieOut #JustSayNoToBadDnD #NoJasonTondro #TTRPG -
DATE: October 22, 2026 at 10:00AM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: New biological marker could end trial and error in depression care
URL: https://www.psypost.org/blood-test-could-predict-if-an-antidepressant-will-work-for-you/
Major depressive disorder is often treated through trial and error, but a blood test may soon help doctors choose the right medication on the first try. Researchers have identified a circular RNA molecule in the blood that predicts whether a patient will respond to a common class of antidepressants. The findings were published in Molecular Psychiatry.
Millions of people globally experience major depressive disorder. Doctors frequently prescribe selective serotonin reuptake inhibitors, commonly known as SSRIs, as a first line of medical defense. These drugs block the reabsorption of serotonin in the brain, leaving more of the chemical available to help transmit messages between nerve cells.
Less than half of patients experience relief from their symptoms after trying their first prescribed antidepressant. This forces patients to spend months trying different medications before finding one that works. The prolonged wait imposes a heavy burden on individuals and adds substantial costs to the healthcare system.
Medical professionals currently lack biological tests to predict which drug will work for a specific person. Genetic tests exist to show how fast a person’s body might metabolize a drug. They cannot, however, forecast if the drug will actually relieve depression symptoms.
To find a better biological indicator, a team of researchers investigated circular RNAs. These are stable, loop-shaped genetic molecules that influence how other genes operate. Because they lack exposed ends, they resist degrading enzymes in the body, giving them a much longer lifespan than standard linear RNA molecules.
Circular RNAs are highly concentrated in the brain and help regulate how neurons connect and communicate. Some of these molecules can pass through the blood-brain barrier, the semi-permeable membrane that separates circulating blood from brain fluid. Because they leak into the bloodstream in a stable form, researchers can detect brain-derived circular RNAs using a standard blood draw.
The investigation was led by scientists Grigorios Papageorgiou, Eleni T. Tzavara, and Nikolaos Mellios of Circular Genomics and various research institutes in the United States and France, along with Madhukar H. Trivedi at the University of Texas Southwestern Medical Center. They focused on a specific circular RNA called CDR1as. This molecule is highly abundant in the brain but rarely found in other human tissues.
The researchers first analyzed baseline blood samples from patients enrolled in two independent clinical trials. They extracted RNA from the blood of patients diagnosed with major depressive disorder who were about to begin taking the SSRI sertraline. Using a technique that amplifies genetic material, the team measured the starting levels of CDR1as for each patient.
The team found that patients who did not respond to sertraline after eight weeks of treatment had notably higher baseline levels of CDR1as in their blood. Patients who experienced symptom relief had lower starting levels of the molecule. The researchers observed that unaffected control subjects also showed lower baseline levels of the molecule.
Taking advantage of the clinical trial design, the researchers also measured the patients’ blood at different intervals after they started taking sertraline. They discovered that patients who responded well to the drug experienced an increase in CDR1as levels after treatment began. Patients who did not respond to the medication saw no such increase in the molecule’s concentration.
To test if this molecule simply predicts general improvement rather than specific drug responses, the researchers looked at other treatment groups. They measured baseline blood levels in patients who were given a placebo pill. They also evaluated patients who failed to respond to sertraline and were subsequently switched to bupropion, a different type of antidepressant.
Baseline levels of CDR1as did not predict whether a patient would feel better on a placebo. The molecule also failed to predict if a patient would go on to experience remission while taking bupropion. This suggested the biomarker is specifically tied to the mechanisms of sertraline.
The research team then wanted to know if this predictive power applied to the entire SSRI drug class. They examined blood samples from patients in other clinical programs who were taking fluoxetine, citalopram, or escitalopram. They also analyzed samples from a small study of patients taking alternative medications like serotonin and norepinephrine reuptake inhibitors.
The researchers observed that CDR1as levels successfully identified patients who were faring well on various SSRIs, not just sertraline. When evaluating patients taking other classes of antidepressants, the molecule’s levels did not predict symptom relief. This pointed to a specific relationship between the circular RNA and SSRI medications as a whole.
To understand exactly how the brain produces this circular RNA, the team conducted experiments on mice. They administered different chemical compounds to the animals to block specific brain receptors. They then extracted brain tissue to measure changes in Cdr1as, the mouse equivalent of the human molecule.
When the researchers blocked the serotonin 5-HT2A receptor, levels of the circular RNA dropped across three different regions of the mouse brain. Blocking dopamine or glutamate receptors did not produce a similar drop in the molecule. This established a direct link between serotonin system activity and the production of the circular RNA.
The investigators conducted a final set of experiments on lab-grown human and mouse nerve cells. They treated the cells with chemicals that inhibit brain-derived neurotrophic factor, a protein that promotes the survival and growth of neurons. Inhibiting this protein’s receptors caused the cells to produce less of the circular RNA.
The researchers noted that certain medical conditions could interfere with the accuracy of this blood test. For instance, the test performed poorly in depressed patients who had a family history of mania, which is often a sign of undiagnosed bipolar disorder. When the researchers excluded these patients from their analysis, the test’s predictive accuracy improved.
Medical events that disrupt the blood-brain barrier might also artificially alter the amount of circular RNA in the bloodstream. Severe head trauma or strokes could potentially cause these brain molecules to leak into the blood at abnormal rates. Future research will need to verify how such physical injuries influence the test results.
The study authors noted that high baseline levels of the molecule correlated with specific depression symptoms like anhedonia and social withdrawal. These symptoms are often associated with a subtype of depression that is historically harder to treat with SSRIs. Further studies will need to explore exactly how this biological marker overlaps with different clinical subtypes of the disorder.
The study, “A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants,” was authored by Grigorios Papageorgiou, El Chérif Ibrahim, Victor Gorgievski, Gabriella Maxson, Evelyn Lozano, Eric Gordon, Antoine Lefrere, Marie-Julie Toupet, Philippe Courtet, Raoul Belzeaux, Jane Foster, Thomas Carmody, Roy H. Perlis, Madhukar H. Trivedi, Eleni T. Tzavara, and Nikolaos Mellios.
URL: https://www.psypost.org/blood-test-could-predict-if-an-antidepressant-will-work-for-you/
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #DepressionResearch #MentalHealth #DepressionCare #Antidepressants #SSRIs #PrecisionMedicine #Biomarkers #MedicalResearch #BrainHealth #HealthcareInnovation
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Insta360 Mic: E-Ink 2.4GHz Wireless Microphone System with 32-bit float Internal Recording https://www.newsshooter.com/2026/10/22/insta360-mic-e-ink-2-4ghz-wireless-microphone-system-with-32-bit-float-internal-recording/
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Bagudan, comédia reverse harem de Yūichirō Momose (Hypnosis Mic) e Hina Hinata, termina em 24/11 na Monthly Dessert: galãs de otome game viram colegas de classe. Você leu? #animebrasil #animenews
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Uai, a Mônica desceu para área dos animais sozinha. Depois foi Renata. E Mônica na casinha da árvore disse: Rê, me empresta.
Renata foi até a casinha da árvores, tirou alguma coisa da bolsinha do mic e Mônica esticou o casaco para ela passar e ninguém ver.
#EliminaçãoAFazenda #AFazenda18 #AFazenda