#trna — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #trna, aggregated by home.social.
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We've just released major update of #SeqTagger
Notable changes in v2.1a:
- signal standarisation
- rolling-window classification
- new models: b07_RNA004_tRNA & b13_RNA004_mRNA
- backward-compatible with v1 models
- as before, very high speed, precision & recovery!For the first time, SeqTagger supports #tRNA #demultiplexing natively thanks to new rolling-window classification (b07_RNA004_tRNA).
Try it yourself https://github.com/novoalab/SeqTagger
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Pathogenic variants in the #ribosome -associated endoribonuclease SLFN14 cause inherited #thrombocytopenia, but why? This study shows that type II #tRNA cleavage by mutant SLFN14 drives global translational repression and cell death @PLOSBiology https://plos.io/3QegRCk
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Installation of tRNA modifications is key to protein synthesis.
In her presentation at #Biochemistry2026, Carine Tisné presented her group's in depth work on structural and functional studies to understand the underlying processes on the example of m1A.
https://pubs.acs.org/doi/10.1021/acs.accounts.3c00568
#Biochemistry #RNA #tRNA #Modification #ProteinSynthesis #Chemistry #ChemBio #cryoEM #Crystallography
CC: @gdch -
🧬 RNA types work together in protein synthesis 🔬—mRNA carries code, tRNA delivers amino acids, and rRNA builds proteins efficiently 📘.
#TypesOfRNA #mRNA #tRNA #rRNA #ProteinSynthesis #MolecularBiology #LifeScienceStudents #Biotechnology #BiologyConcepts #BioResire -
🧬 Understanding RNA types is essential 🔬—mRNA, tRNA, and rRNA work together to drive accurate protein synthesis in cells 📘.
#TypesOfRNA #mRNA #tRNA #rRNA #MolecularBiology #ProteinSynthesis #LifeScienceStudents #Biotechnology #Microbiology #BioResire
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DATE: December 15, 2025 at 05:30PM
SOURCE: BioWorld MedTechDirect article link at end of text block below.
.@alltrna advances #tRNA-based strategy for stop #codon diseases
Here are any URLs found in the article text:
Articles can be found by scrolling down the page at https://www.bioworld.com/topics/85-bioworld-medtech .
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It's primitive... but it works... mostly...
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-------------------------------------------------#healthcare #healthtech #healthcaretech #healthtechnology #medgadget #medicine #doctor #hospital #medtech
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Uncovering the unique roles of #Exportin_5 in #RNA export within #Drosophila cells.
https://phys.org/news/2024-09-uncovering-unique-roles-exportin-rna.html
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https://www.nature.com/articles/s41467-024-49132-0
"Our structures explain how the hierarchy of the pre-tRNA processing reactions is ensured." 🤯
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Using a collection of locus-barcoded yeast strains and the TAP collection, the van Leeuwen lab identified a factor involved in the regulation of tRNA transcription by RNA #polymerase III. Barcode sequencing was used for the identification of proteins binding to a region of chromatin.
The newly identified Fpt1 (YKR011C) factor was identified in our own large-scale screens to affect growth of yeast cells that lack the pol III regulator Maf1.
https://pubmed.ncbi.nlm.nih.gov/37995691/
http://hub05.hosting.pasteur.fr/GIM_interactions/ -
Designt, verändert und vollkommen neu zusammengesetzt: Das Erbgut eines neuen Hefestamms ist zu mehr als der Hälfte im Labor geschaffen. Bald soll das ganze Genom künstlich sein.#Hefe #Genom #Synthetisch #Biologie #Chromosom #Neochromosom #TRNA #Erbgut #Bierhefe #Saccharomyces #Cerevisiae
Hefe mit zur Hälfte künstlichem Erbgut -
#Queuosine-#tRNA promotes sex-dependent learning and memory formation by maintaining #codon-biased translation elongation speed
Francesca Tuorto and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2022112507 -
This is cool:
"Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC–MS/MS" -
https://www.nature.com/articles/s41587-023-01743-6
"We show that default nanopore sequencing settings discard the vast majority of tRNA reads, leading to poor sequencing yields and biased representations of tRNA abundances based on their transcript length. Re-processing of raw nanopore current intensity signals leads to a 12-fold increase in the number of recovered tRNA reads and enables recapitulation of accurate tRNA abundances"
#transferRNA #tRNA #nanopore #sequencing #singleMolecule #biosensor #nanosensor #nanotech
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Interesting review from Reuven Agami on protein translation in oncogenesis
"Proteome diversification by mRNA translation in cancer"
#mRNA #translation #tRNA #cancer
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01103-0
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Retrotechtacular: Understanding Protein Synthesis Through Interpretive Dance - With the principles of molecular biology very much in the zeitgeist these days, we... - https://hackaday.com/2021/08/01/retrotechtacular-understanding-protein-synthesis-through-interpretive-dance/ #retrotechtacular #molecularbiology #proteinsynthesis #translation #aminoacid #ribosome #dance #mrna #trna #art
