#massspec — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #massspec, aggregated by home.social.
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for GC-MS spectra intrepetation, whats better? Claude Opus or ChatGPT 5.5? #gcms #spectromist #massspec #analyticalchemistry #chromatography ahy -
for GC-MS spectra intrepetation, whats better? Claude Opus or ChatGPT 5.5? #gcms #spectromist #massspec #analyticalchemistry #chromatography ahy -
for GC-MS spectra intrepetation, whats better? Claude Opus or ChatGPT 5.5? #gcms #spectromist #massspec #analyticalchemistry #chromatography ahy -
for GC-MS spectra intrepetation, whats better? Claude Opus or ChatGPT 5.5? #gcms #spectromist #massspec #analyticalchemistry #chromatography ahy -
for GC-MS spectra intrepetation, whats better? Claude Opus or ChatGPT 5.5? #gcms #spectromist #massspec #analyticalchemistry #chromatography ahy -
Matrix Science will be attending BSPR2026 in Cambridge, UK, on 13-15 July. Come chat with us about the latest developments with Mascot. Abstract and early bird registration deadline is 15 May, so it's best to book your place soon!
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You can now use large language model (LLM) coding assistants to interact with Mascot Server. This includes anything that can be programmed with the LLM, from simple automation tasks to complex mining and merging of results.
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Mascot Newsletter, April 2026:
Mycobacteria spectral libraries.
Orthogonal translation systems for lysine aminoacylation.
Matrix Science at ASMS 2026.
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Mascot Newsletter, March 2026:
Search BLIB spectral libraries with Mascot.
PET hydrolase expressed in fruit flies.
UK office has moved.
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matrixscience.com is being overwhelmed by millions of HTTP requests from distributed botnets, essentially a distributed denial of service (DDoS) attack. We are forced to mitigate it by restricting access to certain pages of dynamic content.
https://www.matrixscience.com/whats_new/mitigations-against-uncontrolled-web-crawlers-and-bots.html
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Thunder-DDA-PASEF is an acquisition strategy for capturing more human leukocyte antigen (HLA) class I peptide ligands on Bruker timsTOF instruments. This month's blog shows how you can process Thunder-DDA-PASEF data with Mascot Distiller.
https://www.matrixscience.com/blog/processing-thunder-dda-pasef-data-with-mascot-distiller.html
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Using the blib2msp converter, Mascot Server can now search DDA spectral libraries in BLIB format. Here's an example for identifying mycobacteria.
https://www.matrixscience.com/blog/identifying-mycobacteria-with-custom-spectral-libraries.html
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Mascot Newsletter, February 2026:
Strange software errors? Check your disk space.
Proteomic signatures in human fingertip regeneration.
Customise columns in the search log.
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Mascot Server can create and search NIST MSP formatted spectral libraries but not BLIB -- until now! We have developed an MSP to BLIB to MSP converter that allows Mascot Server to use BLIB libraries.
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Mascot Newsletter, January 2026:
Ion intensity: peak area vs signal to noise?
Duplexing deuterated water-labeled samples for protein turnover rate estimation.
Role-based access with Mascot Security is useful in a variety of cases.
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Proteomics software is prone to filling up the disk with data and temp files, which can cause weird issues. This blog article lists the most common errors in Mascot products and how to free up disk space.
https://www.matrixscience.com/blog/strange-software-failures-check-your-disk-space.html
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🎁 Season’s Greetings & Gratitude
Thanks for choosing us in 2025.
Wishing you a peaceful holiday season and a successful new year — from our team to yours!#mswil #proteomics #LCMS #MassSpec #MassSpectrometry
#Proteomics #Chemistry #BioMedical #Pharmancy #Metabolomics #Physics #MSWil #MakingScienceWork -
Mascot Newsletter, December 2025:
NCBI nr FASTA replacement.
Immunoregulation during pregnancy.
Mascot Server as system service on Linux.
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After a fair bit of frustration, our new excimer laser is installed! We have it coupled to an Element 2, and new laser plus sector magnet (rather than quadupole) mass spectrometry is a steep learning curve for me. Nice to spend the afternoon tinkering in the lab though.
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When raw data is processed into peak lists, there is a choice: how should peak intensity be calculated? Mascot Distiller defaults to peak area. The alternative, signal-to-noise (S/N), can be useful with detecting diagnostic ions.
https://www.matrixscience.com/blog/peak-list-arcana-area-vs-signal-to-noise.html
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Mascot Newsletter, November 2025:
Top-3 quant with DDA-PASEF.
ZooMS peptide markers for South American Xenarthrans.
Migrating from Windows 10 to Linux could extend the lifetime of your hardware.
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The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database -- or you may be better off using TrEMBL.
https://www.matrixscience.com/blog/replacements-for-ncbi-nr.html
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Mascot Newsletter, October 2025:
Spectrum-centric DIA scoring.
Molecular mechanisms of SBK2 kinase on the heart.
Windows update issue with IIS (resolved).
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Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
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Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
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Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
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Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
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Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:
In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.
#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch
https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8
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Mascot Daemon can export protein level quant intensities for replicate LFQ, SILAC and iTRAQ/TMT. The latest version can also export intensity values calculated using the "Top-3" method, illustrated here with DDA-PASEF data.
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I just submitted my manuscript for November's meeting of the NVMS!
#MassSpec #Proteomics #Bioinformatics
@magnuspalmblad
@Stephanhacker2
https://www.nvms.nl/ -
We are pleased to announce a new distributor for Matrix Science products! Customers in India can now buy Mascot Server through BioInnovations, who provide instruments, software, services and consumables for life sciences and analytical and clinical labs. #proteomics #massspec
https://www.matrixscience.com/whats_new/new-mascot-distributor-in-india-bioinnovations.html
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Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA.
https://www.matrixscience.com/blog/probabilistic-spectrum-centric-scoring-for-dia.html
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Mascot Newsletter, August 2025:
Precursor detection for spectrum-centric DIA.
Reconstructing mediaeval monastic diets.
Microsoft has announced the end of Windows 10 support; your Mascot Server may be affected.
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🧵 Thread: 1️⃣/ Caroline Tokarski delivering a masterclass on how #massspec revolutionises our understanding of cultural materials! Her slide perfectly encapsulates the multifaceted insights we can extract - from artist intention to societal context. #teammasspec #heritage
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I love living in the kind of city where this is considered worthy of a plaque. #MassSpec #TeamMassSpec
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Big day at @LeibnizHKI 👏
Thuringia's Econ Minister Colette Boos-John joined us for #EuropeDay to see how EU funding powers science & jobs 💡Thuringia = hotspot for high-tech + health innovation! 💪
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Multimodal imaging of tissue using the combination of vibrational spectroscopy and mass spectrometry.
Applied Spectroscopy Reviews, 1–25
https://doi.org/10.1080/05704928.2025.2488469🦋 Follow us on Bluesky too: https://bsky.app/profile/clirspec.org
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Does anyone with a degree in chemistry have any idea what the authors mean with this? HOW did they end up with 5 different functional fractions? #chemistry #OC #HPLC #MassSpec
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I am super excited to be an invited speaker at AUS-oMicS 2025 in beautiful Cairns. I'll be talking about my work using mass spectrometry to track pollutants in the environment and assess their effects on biological systems via #metabolomics.
The oral abstract submission deadline has been extended until February 14th 2025. Submit yours today and register at https://www.ausomics.comSee you there!
#TeamMassSpec #massspectrometry #massspec #ozchem #science #australia
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Having a great time at the #EuBIC2025 developers meeting with our #SpectriPy hackathon for combined #rstats :rstats: / #Python :python: #MassSpec data analysis.
Here part of our team on a short hike ⛰️ to get some fresh air for our 🧠
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Looking for opinions on which 193 nm excimer laser ablation unit to get to couple with our Element 2 for high-res analysis trace and minor elements in carbonates (esp. speleothems). Trying to choose between RESOlution or ESL. If any geochemists/LAICPMS afficonados on here have OPINIONS on either of these (good or bad), please drop me a line!
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New publication from the lab in Methods in Enzymology 📖: A chapter on #massspec based study of #mitochondrial translocation proteins. Free copy available at: https://authors.elsevier.com/a/1jenP_1lc7fPeK
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Not sure if enough #massspec people are here but I need some help for #hplc #troubleshooting: Have you ever found brownish dirt in your LC valves? We see this now accumulating since several months but have changed neither protocols nor solvents. Doing #proteomics with MS-grade solvents using mostly C18 stage tipping sample prep and an Ultimate3000 LC. Any ideas welcome!
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Our new preprint, presenting PulsPhos, a novel method for proteome-wide measurement of the dynamics of protein phosphorylation at specific sites in living cells, is now out!
This required inventing an elegant strategy for measuring the pool of available phosphates in, which allows us to account for the complex biotransformations of phosphates that occur in intact cells.
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A passionate call by Jana for #OpenScience and #OpenData in #Exposomics and #MassSpec research.
And an impressive resource she and the #RECETOX labs at Masaryk University, CZ, have set up at zenodo.org/communities/rcx-balriLeading by example and using #Zenodo and #UseGalaxy as building blocks seems like the way to go!
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A passionate call by Jana for #OpenScience and #OpenData in #Exposomics and #MassSpec research.
And an impressive resource she and the #RECETOX labs at Masaryk University, CZ, have set up at zenodo.org/communities/rcx-balriLeading by example and using #Zenodo and #UseGalaxy as building blocks seems like the way to go!
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A passionate call by Jana for #OpenScience and #OpenData in #Exposomics and #MassSpec research.
And an impressive resource she and the #RECETOX labs at Masaryk University, CZ, have set up at zenodo.org/communities/rcx-balriLeading by example and using #Zenodo and #UseGalaxy as building blocks seems like the way to go!
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A passionate call by Jana for #OpenScience and #OpenData in #Exposomics and #MassSpec research.
And an impressive resource she and the #RECETOX labs at Masaryk University, CZ, have set up at zenodo.org/communities/rcx-balriLeading by example and using #Zenodo and #UseGalaxy as building blocks seems like the way to go!
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A passionate call by Jana for #OpenScience and #OpenData in #Exposomics and #MassSpec research.
And an impressive resource she and the #RECETOX labs at Masaryk University, CZ, have set up at zenodo.org/communities/rcx-balriLeading by example and using #Zenodo and #UseGalaxy as building blocks seems like the way to go!