#drugdesign — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #drugdesign, aggregated by home.social.
-
To treat diseases, proteins are often targeted for inhibition. Recently, PROTACs emerged as an alternative approach, degrading proteins by recruiting a ubiquitinase followed by a protease.
In J Med Chem, Darci Trader (UC California) and colleagues demonstrated that the protease can be engaged without ubiquitinase recruitment. Though early-stage and less active than PROTACs, this offers a promising new direction.