#protac — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #protac, aggregated by home.social.
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Der Förderverein des HZI und die @tubraunschweig haben den Naturstoffforscher Craig Crews mit der #Inhoffen-Medaille 2026 ausgezeichnet! Crews ist ein Pionier der #PROTAC-Technologie und hat die Grenzen der #Wirkstoffforschung erweitert.
https://www.helmholtz-hzi.de/media-center/newsroom/news-detailseite/craig-crews-mit-inhoffen-medaille-2026-ausgezeichnet/ -
Amazing news that the first #PROTAC for targeted protein degradation has been approved by the FDA. Great to see an entirely new modality added to the therapeutic toolbox.
https://news.yale.edu/2026/05/07/yale-led-technology-receives-fda-approval-breast-cancer-treatment
Very curious to see, how the field of induced proximity will develop further into the future with so many additional exciting applications already shown in basic academic research. Curious, which other therapeutic areas will most profit from this development. (1/2)
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?
🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028
📚 CSBJ: https://www.csbj.org/
#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95939
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95939 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95680
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95680 -
Postdoctoral Fellow
Ruijin Hospital
The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.
See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95470
#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95470 -
Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q
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#PROTAC from @Novartis team recruiting DCAF1, an E3 ligase essential in cancer, rescues BTK degradation in a cell line that acquired resistance to a CRBN-recruiting PROTAC. Great mechanistic PoC, even though overall effect on cell viability is not as pronounced. https://www.biorxiv.org/content/10.1101/2023.04.09.536153v1
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Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3 -
Happy #Heterobifunctional Holidays from the Crewslab! #PROTAC #chemicalbiology #Yale
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First post an a short intro. I’m a medicinal chemist/drug discoverer in academia. My group works on a variety of areas: cancer and neuroscience mainly. For (permanent) fun, when my students discover an in vivo probe, it gets tattooed on me. Can’t wait for our #PROTAC project to be successful, may need my leg.
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The eBook of Inducing Targeted Protein Degradation (Ed. Philipp Cromm, published by Wiley-VCH) is now available! Get yours today. Featuring a chapter by me and Erika Araujo. Print edition coming in December. #TPD #TargetedProteinDegradation #PROTAC
https://www.wiley.com/en-gb/Inducing+Targeted+Protein+Degradation%3A+From+Chemical+Biology+to+Drug+Discovery+and+Clinical+Applications-p-9783527350179 -
Nice paper from the Schapira lab identifying potential #ligand binding pockets for future #PROTAC development.
https://www.sciencedirect.com/science/article/pii/S2001037022005049#b0040
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I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup