#gpcr — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #gpcr, aggregated by home.social.
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Creating a GPCR family activated by an inert ligand
🧪 Evolved muscarinic GPCRs, responsive only to CNO
⚙️ Achieved cell signaling without native ligands
📊 Used mutant receptors to study signaling pathways for msd#GPCR #MolecularEvolution #DREADD #Pharmacology #CellEngineering
https://dev.https://tnyp.me/CcS0q4hQ/m
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https://www.europesays.com/dk/46638/ Which Obesity Stock is the Better Buy Right Now? #GPCR #NovoNordisk #NVOStock #TypeIIDiabetes #ZacksInvestmentResearch
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🧬 Can entropy help us decode how hormone receptors make real-time decisions?
🔗 Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.024
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #Biophysics #GPCR #Entropy #MolecularPharmacology #AllostericModulation #DrugDiscovery #MolecularDynamics
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🧬 Can entropy help us decode how hormone receptors make real-time decisions?
🔗 Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.024
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #Biophysics #GPCR #Entropy #MolecularPharmacology #AllostericModulation #DrugDiscovery #MolecularDynamics
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💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?
🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039
📚 CSBJ: https://www.csbj.org/
#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling
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💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?
🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039
📚 CSBJ: https://www.csbj.org/
#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling
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β-arrestins regulate #GPCR signaling & trafficking, adopting multiple conformational states with different outcomes. This study shows how receptor CXCR7 induces stepwise conformational changes in β- #arrestin 2, uncovering an arginine switch mechanism of activation @PLOSBiology https://plos.io/3UfTd71
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β-arrestins regulate #GPCR signaling & trafficking, adopting multiple conformational states with different outcomes. This study shows how receptor CXCR7 induces stepwise conformational changes in β- #arrestin 2, uncovering an arginine switch mechanism of activation @PLOSBiology https://plos.io/3UfTd71
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β-arrestins regulate #GPCR signaling & trafficking, adopting multiple conformational states with different outcomes. This study shows how receptor CXCR7 induces stepwise conformational changes in β- #arrestin 2, uncovering an arginine switch mechanism of activation @PLOSBiology https://plos.io/3UfTd71
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β-arrestins regulate #GPCR signaling & trafficking, adopting multiple conformational states with different outcomes. This study shows how receptor CXCR7 induces stepwise conformational changes in β- #arrestin 2, uncovering an arginine switch mechanism of activation @PLOSBiology https://plos.io/3UfTd71
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Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
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Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
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Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
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Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
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Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysiker der #UniLeipzig weisen Mechanismus der #Signalübertragung durch Adrenalin-bindenden #Rezeptor auf atomarer Ebene nach. Mit den Ergebnissen könnten Forschende künftig Nebenwirkungen bei #Entwicklung von Wirkstoffen umgehen.
#GPCR @SFB1423 -
Biophysiker der #UniLeipzig weisen Mechanismus der #Signalübertragung durch Adrenalin-bindenden #Rezeptor auf atomarer Ebene nach. Mit den Ergebnissen könnten Forschende künftig Nebenwirkungen bei #Entwicklung von Wirkstoffen umgehen.
#GPCR @SFB1423 -
Biophysiker der #UniLeipzig weisen Mechanismus der #Signalübertragung durch Adrenalin-bindenden #Rezeptor auf atomarer Ebene nach. Mit den Ergebnissen könnten Forschende künftig Nebenwirkungen bei #Entwicklung von Wirkstoffen umgehen.
#GPCR @SFB1423 -
The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#contentFor #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.
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The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#contentFor #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.
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The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#contentFor #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look! -
For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look! -
For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look! -
For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look! -
#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
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#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
(1/2)
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#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
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#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
(1/2)
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#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
(1/2)
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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Research reveals molecular mechanism of asymmetric #calcium_sensitive #receptor activation.
https://phys.org/news/2023-11-reveals-molecular-mechanism-asymmetric-calcium-sensitive.html
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Research reveals molecular mechanism of asymmetric #calcium_sensitive #receptor activation.
https://phys.org/news/2023-11-reveals-molecular-mechanism-asymmetric-calcium-sensitive.html
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#Glucagon #receptor structures uncover new #arrestin interaction mechanism.
#signalling #transduction #GPCR
https://phys.org/news/2023-08-glucagon-receptor-uncover-arrestin-interaction.html
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#Glucagon #receptor structures uncover new #arrestin interaction mechanism.
#signalling #transduction #GPCR
https://phys.org/news/2023-08-glucagon-receptor-uncover-arrestin-interaction.html
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First preprint about my work at Schrödinger:
We show how to predict ligand efficacy via absolute binding free energy perturbation on different receptor conformations — confirming and utilizing the principle that the functional response of a receptor is mainly determined by the thermodynamics of ligand binding.
https://chemrxiv.org/engage/chemrxiv/article-details/64b1cccaae3d1a7b0db45aa8
#FEP #FreeEnergy #LigandEfficacy #GPCR #DrugDiscovery #DrugDesign #Thermodynamics #GPCRs #BindingFreeEnergy
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First preprint about my work at Schrödinger:
We show how to predict ligand efficacy via absolute binding free energy perturbation on different receptor conformations — confirming and utilizing the principle that the functional response of a receptor is mainly determined by the thermodynamics of ligand binding.
https://chemrxiv.org/engage/chemrxiv/article-details/64b1cccaae3d1a7b0db45aa8
#FEP #FreeEnergy #LigandEfficacy #GPCR #DrugDiscovery #DrugDesign #Thermodynamics #GPCRs #BindingFreeEnergy