#gpcr — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #gpcr, aggregated by home.social.
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🧬 Can entropy help us decode how hormone receptors make real-time decisions?
🔗 Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.024
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #Biophysics #GPCR #Entropy #MolecularPharmacology #AllostericModulation #DrugDiscovery #MolecularDynamics
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💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?
🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039
📚 CSBJ: https://www.csbj.org/
#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling
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💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?
🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039
📚 CSBJ: https://www.csbj.org/
#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling
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β-arrestins regulate #GPCR signaling & trafficking, adopting multiple conformational states with different outcomes. This study shows how receptor CXCR7 induces stepwise conformational changes in β- #arrestin 2, uncovering an arginine switch mechanism of activation @PLOSBiology https://plos.io/3UfTd71
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Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.https://biorxiv.org/content/10.1101/2024.10.31.621373v1
Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)
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Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysicists at #UniLeipzig demonstrate mechanism of #signalling by adrenaline-binding #receptor at atomic level. In the future, researchers could use the results to avoid side effects when developing drugs.
#GPCR @SFB1423 -
Biophysiker der #UniLeipzig weisen Mechanismus der #Signalübertragung durch Adrenalin-bindenden #Rezeptor auf atomarer Ebene nach. Mit den Ergebnissen könnten Forschende künftig Nebenwirkungen bei #Entwicklung von Wirkstoffen umgehen.
#GPCR @SFB1423 -
The version of record of our #Nematostella #GPCR #neuropeptide paper has now been published
https://elifesciences.org/articles/90674#contentFor #cnidarian #neuroscience there are lots of new deorphanised receptors described in the paper. We also identified orthologs across cnidarian species, including corals, #Exaiptasia etc. so the resource is not limited to Nematostella.
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New study shows that the C-terminal fragment of the #GPCR #muscarinicM2receptor, translated from an #IRES, localizes to the #mitochondrial inner membrane & is upregulated upon stress exposure, reducing respiration & #ROS to protect cells #PLOSBiology https://plos.io/3Uomtb8
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For our #Nematostella neuropeptide-GPCR screen paper https://elifesciences.org/reviewed-preprints/90674v1, we have now published a detailed protocol here:
https://www.bio-protocol.org/exchange/preprintdetail?type=3&id=2493
If you are interested in #GPCR #neuropeptide #pharmacology #cnidaria #neuroscience have a look! -
#BC007 ist ein potenzieller Wirkstoffkandidat gegen das #PostCovidSyndrom und andere #Autoimmunkrankheiten mit funktionellen Autoantikörpern gegen #GProtein gekoppelte Rezeptoren #gpcr Es handelt sich um ein #aptamer das diese krankmachenden #Autoantikörper blockieren soll. Die klinische Phase-II-Studie reCOVer der Augenklinik des #Uniklinikums #Erlangen untersucht den molekularen Weg bestimmter Autoantikörper beim Post-COVID-Syndrom. In diesem Zusammenhang startet in …
(1/2)
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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First preprint about my work at Schrödinger:
We show how to predict ligand efficacy via absolute binding free energy perturbation on different receptor conformations — confirming and utilizing the principle that the functional response of a receptor is mainly determined by the thermodynamics of ligand binding.
https://chemrxiv.org/engage/chemrxiv/article-details/64b1cccaae3d1a7b0db45aa8
#FEP #FreeEnergy #LigandEfficacy #GPCR #DrugDiscovery #DrugDesign #Thermodynamics #GPCRs #BindingFreeEnergy
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Our favourite #Platynereis #opsin now in the mammalian brain as a new #optogenetic tool!
"Here we ... found that the Platynereis dumerilii ciliary opsin ... is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo "
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Previously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience -
In our new preprint we characterise neuropeptide signalling in the cnidarian #Nematostella.
https://www.biorxiv.org/content/10.1101/2023.07.03.547448v1
Daniel Thiel and Luis Yanez-Guerra screened 64 neuropeptides against 161 G-protein coupled receptors (#GPCR) and found activating peptide ligands for 31 receptors.
#cnidaria #neuropeptide #evolution #neuroscience -
🚨#Optogenetic preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #optogenetics #neuroscienceLink:
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In dieser Fallserie zur Behandlung von #LongCovid durch #Immunadsorption konnte leider keine Wirksamkeit festgestellt werden.
Mögliche Ursachen sind
- Membrangebundene #Autoantikörper konnten nicht entfernt werden.
- Die Krankheit war bereits chronifiziert.
- Autoantikörper sind nur ein Epiphänomen.
- Autoantikörper werden zu schnell nachgebildet. -
date: 2023-02-10 10:52:06
by: Peter Kenny 🇹🇹🇬🇧🇧🇷🇺🇦🌻🇪🇺🇲🇦#PhD opportunity - Analysis/prediction of ligand signaling pathways in G protein-coupled receptors at (University of Glasgow/Queens University Belfast UK) #GPCR #GPR48 #pharmacol #simulations #ML https://www.gla.ac.uk/colleges/mvls/graduateschool/northwestbio/projects/bioscience/integratedapproachesinpharmacologycomputersimulationsandmachinelearning/
🐦🔗: https://twitter.com/twitter/statuses/1623998237425139712
#PhdPosition -
Once in a while, I still wonder how a #GPCR with a fluorescent protein inserted in ICL3 can do any signaling.
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I closed my Twitter account this week.
Interested in #pancreaticislets #diabetes #metabolism #medicalresearch #gpcr #insulin -
Made our own #GPCR #gingerbread cookies. Few with some serious mutations 😂. h/t @cllantz for the fun cookie cutters
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"Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered. " https://www.sciencedirect.com/science/article/pii/S0969212621004172 … #GPCR #dynamics by Rajan Lamichhane, Matthew Eddy and co-authors
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New #preprint about PENSA, our flexible #OpenSource software package for comprehensive and thorough investigation of biomolecular conformational ensembles:
https://arxiv.org/abs/2212.02714
In three real-world examples, we show how it can be used to understand an #enzyme mechanism, #DNA #forcefield parameters, and #signaling in an #opioid #receptor.
Please share widely with the #MolecularDynamics #simulation #CompChem #MolBio #StructuralBiology #GPCR communities!
Feedback and ideas are always welcome. -
An overview paper on recent updates to GPCRdb:
https://doi.org/10.1093/nar/gkac1013