#hta — Public Fediverse posts

Trial retention is now an HTA evidence-governance issue: missing outcomes can weaken comparative estimates, utility inputs, and reimbursement models. https://www.mattheneus.com/editorial/trial-retention-outcome-data-completeness-hta-evidence-governance-playbook-2026-04-22 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

Gold rush for APL member gardens at Harrogate Spring Flower Show https://www.allforgardening.com/1736328/gold-rush-for-apl-member-gardens-at-harrogate-spring-flower-show/ #APL #garden #HarrogateSpringFlowerFestival #HTA

HTA evidence teams are hitting a fragmentation wall: ITC, MAIC, NMA, RWE, modelling, and reporting now need one traceable workflow, not stitched-together handoffs. https://www.mattheneus.com/editorial/abangelabs-hta-studio-itc-foundation-end-to-end-hta-evidence-platform-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis #HealthEconomics

G-BA says concizumab's added benefit is not proven in haemophilia A because comparator alignment still decides whether evidence lands or unravels. https://www.mattheneus.com/editorial/g-ba-concizumab-haemophilia-a-added-benefit-not-proven-comparator-mismatch-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis

NICE’s fezolinetant decision is a live case study in how reimbursement can clear despite uncertain indirect evidence beyond placebo. The real lesson is comparator-bridge discipline, not false certainty. https://www.mattheneus.com/editorial/nice-fezolinetant-menopause-final-guidance-indirect-comparison-uncertainty-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

Single-arm evidence can price in uncertainty unless HTA assumptions are explicitly governed. https://www.mattheneus.com/editorial/gene-therapy-single-arm-hta-economic-evidence-playbook-2026-03-27 #HTA #MAIC #HealthEconomics #RegulatoryAffairs

HAS France NMA Acceptability Framework: A Cross-Agency Evidence Planning Playbook.

https://www.mattheneus.com/editorial/fallback-canary-has-france-nma-acceptability-framework-evidence-planning-playbook-2026-03-27

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Bridging HAS and IQWiG Evidence Standards: A Cross-Border Network Meta-Analysis Planning Playbook.

https://www.mattheneus.com/editorial/fallback-canary-has-iqwig-cross-border-nma-evidence-planning-playbook-2026-03-26

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

MHRA's patient-information modernisation and device advice refresh set a new evidence-operations baseline.

https://www.mattheneus.com/editorial/mhra-improving-patient-information-device-regulatory-advice-evidence-operations-playbook-2026-03-19

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

EMA Management Board ePI roadmap turns product-information governance into an HTA evidence operations priority.

https://www.mattheneus.com/editorial/ema-management-board-epi-roadmap-evidence-operations-playbook-2026-03-14

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Governance gets stronger when patient and consumer voice is formalized early in HTA. https://www.mattheneus.com/editorial/hta-consumer-panel-governance-playbook-singapore-ace-2026-03-29 #HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

EMA weekly PIP and PSUSA cadence is now an evidence-maintenance signal, not admin noise. https://www.mattheneus.com/editorial/ema-pip-psusa-weekly-cadence-evidence-maintenance-playbook-2026-03-10 #HTA #MAIC #EvidenceSynthesis #RegulatoryAffairs

CADTH Reimbursement Reviews: ITC and NMA Evidence Standards for Canadian Market Access. https://www.mattheneus.com/editorial/cadth-reimbursement-review-itc-nma-evidence-standards-canada-market-access-playbook-2026-03-26 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

Top-journal NMA quality gaps now demand transitivity-first governance in HTA evidence programs

https://www.mattheneus.com/editorial/nma-reporting-rigor-top-medical-journals-transitivity-governance-playbook-2026-03-24

#HTA #NMA #MAIC #EvidenceSynthesis #Pharma

Adaptive trial outputs are colliding with economic modelling timelines: an HTA evidence governance playbook https://www.mattheneus.com/editorial/adaptive-trial-to-economic-model-lineage-hta-evidence-governance-playbook-2026-03-23 #HTA #NMA #MAIC #HealthEconomics #EvidenceSynthesis

Cross-country HTA evidence transfer is now a credibility bottleneck: a new 2026 review finds inverse-odds weighting dominates practice while true transportability remains limited. What’s your governance plan for target-population assumptions? https://www.mattheneus.com/editorial/hta-transportability-iosw-cross-country-evidence-transfer-playbook-2026-03-23 #HTA #MAIC #NMA #EvidenceSynthesis #RWE

IQWiG reports added benefit not proven for lisocabtagene maraleucel in relapsed or refractory mantle cell lymphoma. https://www.mattheneus.com/editorial/iqwig-lisocabtagene-maraleucel-mcl-added-benefit-not-proven-unanchored-maic-2026-03-16 #HTA #MAIC #EvidenceSynthesis #Pharma

FDA approves dupilumab efficacy supplement for allergic fungal rhinosinusitis with AIMS trial basis

https://www.mattheneus.com/editorial/fda-dupixent-afrs-efficacy-supplement-aims-nct04684524-2026-02-23

#HTA #NMA #MAIC #RegulatoryAffairs #Pharma

EMA operationalises new PRIME tools and resets evidence-readiness expectations for 2026 submissions. https://www.mattheneus.com/editorial/ema-prime-three-feature-evidence-readiness-playbook-2026-03-18 #HTA #MAIC #RegulatoryAffairs #Pharma

NICE TA1140 final guidance recommends ruxolitinib cream for non-segmental vitiligo after rapid review https://www.mattheneus.com/editorial/nice-ruxolitinib-cream-ta1140-final-guidance-non-segmental-vitiligo-2026-03-17 #HTA #MAIC #RegulatoryAffairs #HealthEconomics

Cross-domain NMA transitivity stress-testing: a March 2026 playbook for decision teams https://www.mattheneus.com/editorial/cross-domain-nma-transitivity-stress-testing-playbook-2026-03-16 #HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Depression HTA decisions can fail when outcome scales are misaligned across trials—this playbook shows how to keep ITC/NMA comparisons decision-grade. https://www.mattheneus.com/editorial/depression-outcome-measurement-heterogeneity-itc-nma-comparability-playbook-2026-03-15 #HTA #NMA #MAIC #EvidenceSynthesis #RWE

New editorial: NICE TA1121 recommends acoramidis and formalises a comparator-bridge evidence standard in transthyretin cardiomyopathy
https://www.mattheneus.com/editorial/nice-acoramidis-ta1121-recommendation-maic-comparator-bridge-2026-03-15
#HTA #MAIC #EvidenceSynthesis #Pharma

New HTA brief: SMC accepts Alyftrek for restricted NHSScotland use, with evidence lineage anchored in active-comparator CFTR-modulator studies

https://www.mattheneus.com/editorial/smc-alyftrek-restricted-acceptance-cftr-modulator-active-comparator-lineage-2026-03-14

#HTA #NMA #MAIC #EvidenceSynthesis #RWE

SMC submission-route mix in March 2026 signals a four-lane evidence architecture for faster HTA readiness

https://www.mattheneus.com/editorial/smc-submission-type-routing-evidence-readiness-playbook-2026-03-14

#HTA #NMA #MAIC #EvidenceSynthesis

Anchored comparator discipline is becoming the differentiator for HTA-ready indirect evidence this year. https://www.mattheneus.com/editorial/anchored-itc-common-comparator-governance-playbook-2026-03-14
#HTA #MAIC #NMA #EvidenceSynthesis #RegulatoryAffairs

SMC acceptance in grade 2 glioma sharpens the evidence signal for earlier treatment sequencing discussions. https://www.mattheneus.com/editorial/smc-vorasidenib-voranigo-acceptance-grade2-glioma-phase3-lineage-2026-03-09 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

PRAC safety updates can ripple into access strategy faster than most teams expect. https://www.mattheneus.com/editorial/ema-ixchiq-prac-aseptic-meningitis-product-information-update-2026-03-12 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

AbangeLabs ITC Studio: From MAIC-Centric Workflow to a Three-Ecosystem ITC Architecture. https://www.mattheneus.com/editorial/abangelabs-itc-studio-three-ecosystem-upgrade-executive-overview-2026-03-13 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

AI reporting lineage controls are becoming the decisive factor for HTA-ready evidence synthesis. https://www.mattheneus.com/editorial/ai-reporting-lineage-controls-hta-evidence-readiness-playbook-2026-03-12 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

British Garden Centres meet with MP Priti Patel to highlight mounting financial pressures facing the horticultural sector https://www.allforgardening.com/1623812/british-garden-centres-meet-with-mp-priti-patel-to-highlight-mounting-financial-pressures-facing-the-horticultural-sector/ #BritishGardenCentres #garden #HTA

HTA celebrate 20 years of the Garden Press Event https://www.allforgardening.com/1615907/hta-celebrate-20-years-of-the-garden-press-event/ #garden #GardenPressEvent #HTA

Fałszywe repozytoria GitHub z narzędziami OSINT rozprzestrzeniają złośliwe oprogramowanie

Osoby związane z szeroko rozumianym IT, zarządzające systemami czy tworzące oprogramowanie, to szczególnie łakomy kąsek dla grup przestępczych działających w cyfrowym świecie. Nie jest to nowe zjawisko. Tym razem mamy do czynienia z pewną ewolucją. TLDR: Cyberprzestępcy zamiast łamać platformy zdecydowali się uderzyć w nasz najczulszy punkt, jakim jest zaufanie....

#Aktualności #Fileless #Github #Hta #Kryptowaluty #Malware #OSINT #RAT

https://sekurak.pl/falszywe-repozytoria-github-z-narzedziami-osint-rozprzestrzeniaja-zlosliwe-oprogramowanie/

Will I, despite all the angst and disappointment, have managed to include a slide about Sampdoria in my talk on missing data, at tomorrow ISPOR conference session?

Come and find out for yourself... 😉

#HTA #isporEurope #missingdata #bayesianmodelling

Webinar: Making Health Economic Models Shiny — Excel → R & Shiny

Tue Nov 18 · 8am PT / 11am ET / 4pm GMT

Practical migration tips for HTA teams: pitfalls, workflows, reproducibility.

Speakers: Dr Robert Smith, Dr Wael Mohammed (Dark Peak Analytics)

Register: https://r-consortium.org/webinars/making-health-economic-models-shiny.html

#rstats #Shiny #HTA #healthcare

Ejecución sin archivos: cargadores HTA y PowerShell ejecutan RATs https://blog.elhacker.net/2025/05/fileless-remcos-rat-hta-lnk-powershell.html #powershell #fileless #Malware #hta #lnk #rat

European #HTA agencies and the #EMA developed joint positions for better #evidence

A key result of the workshops: Drug studies should be designed in such a way that they address both regulatory questions and the essential research questions of benefit assessments.

Our press release: https://www.iqwig.de/en/presse/press-releases/press-releases-detailpage_143936.html

Europäische #HTA-Agenturen und die #EMA erarbeiten gemeinsame Positionen für bessere #Evidenz

Zentrales Ergebnis: Arzneimittelstudien sollten so gestaltet sein, dass sie sowohl Zulassungsfragen als auch die wesentlichen Fragen der Nutzenbewertung klären.

Unsere Meldung: https://www.iqwig.de/presse/pressemitteilungen/pressemitteilungen-detailseite_143936.html

#EbM

SideWinder targets the maritime and nuclear sectors with an updated toolset – Source: securelist.com https://ciso2ciso.com/sidewinder-targets-the-maritime-and-nuclear-sectors-with-an-updated-toolset-source-securelist-com/ #rssfeedpostgeneratorecho #APT(Targetedattacks) #MalwareDescriptions #MalwareTechnologies #CyberSecurityNews #Targetedattacks #Defenseevasion #Windowsmalware #securelistcom #spearphishing #APTreports #JavaScript #SideWinder #shellcode #Malware #.NET #APT #HTA

SideWinder targets the maritime and nuclear sectors with an updated toolset – Source: securelist.com https://ciso2ciso.com/sidewinder-targets-the-maritime-and-nuclear-sectors-with-an-updated-toolset-source-securelist-com/ #rssfeedpostgeneratorecho #APT(Targetedattacks) #MalwareDescriptions #MalwareTechnologies #CyberSecurityNews #Targetedattacks #Defenseevasion #Windowsmalware #securelistcom #spearphishing #APTreports #JavaScript #SideWinder #shellcode #Malware #.NET #APT #HTA

2025-01-09 (Thursday):

#CVE-2017-0199 Excel (#XLS) file --> #HTA --> #VBS --> #steganography --> #DBatLoader or #GuLoader style malware for #AgentTesla. Data exfil over FTP. A #pcap from an infection, the associated malware, and more info available at www.malware-traffic-analysis.net/2025/01/09/index.html

Cloud Atlas seen using a new tool in its attacks – Source: securelist.com https://ciso2ciso.com/cloud-atlas-seen-using-a-new-tool-in-its-attacks-source-securelist-com/ #rssfeedpostgeneratorecho #MalwareDescriptions #MalwareTechnologies #CyberSecurityNews #Windowsmalware #Cloudservices #securelistcom #CloudAtlas #PowerShell #datatheft #backdoor #Phishing #Telegram #Malware #DLL #HTA #VBS

Cloud Atlas seen using a new tool in its attacks – Source: securelist.com https://ciso2ciso.com/cloud-atlas-seen-using-a-new-tool-in-its-attacks-source-securelist-com/ #rssfeedpostgeneratorecho #MalwareDescriptions #MalwareTechnologies #CyberSecurityNews #Windowsmalware #Cloudservices #securelistcom #CloudAtlas #PowerShell #datatheft #backdoor #Phishing #Telegram #Malware #DLL #HTA #VBS

Cloud Atlas seen using a new tool in its attacks – Source: securelist.com https://ciso2ciso.com/cloud-atlas-seen-using-a-new-tool-in-its-attacks-source-securelist-com/ #rssfeedpostgeneratorecho #MalwareDescriptions #MalwareTechnologies #CyberSecurityNews #Windowsmalware #Cloudservices #securelistcom #CloudAtlas #PowerShell #datatheft #backdoor #Phishing #Telegram #Malware #DLL #HTA #VBS

New release (v. 2.0.2)for #survHE now on CRAN

https://gianluca.statistica.it/software/survhe/

#rstats #HTA #survival

Топ опасных уязвимостей июля. Под угрозой пользователи ОС Windows и Linux

Хабр, привет! Я Александр Леонов, ведущий эксперт лаборатории PT Expert Security Center. Мы с коман­­дой аналитиков Positive Technologies каждый месяц исследуем информацию об уязвимостях из баз и бюллетеней безопасности вендоров, социальных сетей, блогов, телеграм-каналов, баз эксплойтов, публичных репозиториев кода и выявляем во всем этом многообразии трендовые уязвимости. То есть те недостатки безопасности, которые либо уже эксплуатируются вживую, либо могут начать эксплуатироваться в ближайшее время. Сегодня расскажу про самые опасные уязвимости июля. Всего таких уязвимостей было три: 1️⃣ Уязвимость, приводящая к спуфингу, в движке для обработки и отображения HTML-страниц Microsoft Windows MSHTML Platform (CVE-2024-38112). 2️⃣ Уязвимость, связанная с выполнением произвольного кода в интерпретаторе PostScript и PDF-документов Ghostscript (CVE-2024-29510). 3️⃣ Уязвимость, связанная с выполнением произвольного кода в гиперконвергентной [1] платформе Acronis Cyber Infrastructure (CVE-2023-45249). Узнать самые опасные уязвимости июля

https://habr.com/ru/companies/pt/articles/834630/

#трендовые_уязвимости #эксплойт #linux #windows #hta #internet_explorer #ghostscript #metasploit #aci

Jetzt noch mitmachen: Ende Juli endet die diesjährige Einreichungsrunde für unseren ThemenCheck Medizin!

Worum und wie das geht und welche medizinischen Fragen Bürger*innen uns in den jetzten Jahren schon gestellt haben - all das steht hier: https://www.iqwig.de/sich-einbringen/themencheck-medizin/

#HTA #HealthTechnologyAssessment

Registrations are open for the online Health Technology Assessment (HTA) summer workshop the R for Health Technology Assessment Academic Consortium offers! 🌐📊 https://r-hta.org/

Join us to enhance your HTA skills using R. Learn more and register here: https://r-hta.org/events/workshop/2024/

#HTA #HealthTech #RStats #Workshop

Realising the potential of HTA Reform [Promoted content] https://www.euractiv.com/section/health-consumers/opinion/realising-the-potential-of-hta-reform/?utm_source=dlvr.it&utm_medium=mastodon #Accesstomedicines #healthcare #HTA #Innovation #lifesciences

Hot off the press with Spyridon Poulimenos and Jeff Round

https://journals.sagepub.com/doi/abs/10.1177/0272989X241239899

#hta #bayesianMethodsHealthEconomics #utility #uncertainty