#evidencesynthesis — Public Fediverse posts

Trial retention is now an HTA evidence-governance issue: missing outcomes can weaken comparative estimates, utility inputs, and reimbursement models. https://www.mattheneus.com/editorial/trial-retention-outcome-data-completeness-hta-evidence-governance-playbook-2026-04-22 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

HTA evidence teams are hitting a fragmentation wall: ITC, MAIC, NMA, RWE, modelling, and reporting now need one traceable workflow, not stitched-together handoffs. https://www.mattheneus.com/editorial/abangelabs-hta-studio-itc-foundation-end-to-end-hta-evidence-platform-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis #HealthEconomics

G-BA says concizumab's added benefit is not proven in haemophilia A because comparator alignment still decides whether evidence lands or unravels. https://www.mattheneus.com/editorial/g-ba-concizumab-haemophilia-a-added-benefit-not-proven-comparator-mismatch-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis

NICE’s fezolinetant decision is a live case study in how reimbursement can clear despite uncertain indirect evidence beyond placebo. The real lesson is comparator-bridge discipline, not false certainty. https://www.mattheneus.com/editorial/nice-fezolinetant-menopause-final-guidance-indirect-comparison-uncertainty-2026-04-02 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

HAS France NMA Acceptability Framework: A Cross-Agency Evidence Planning Playbook.

https://www.mattheneus.com/editorial/fallback-canary-has-france-nma-acceptability-framework-evidence-planning-playbook-2026-03-27

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Bridging HAS and IQWiG Evidence Standards: A Cross-Border Network Meta-Analysis Planning Playbook.

https://www.mattheneus.com/editorial/fallback-canary-has-iqwig-cross-border-nma-evidence-planning-playbook-2026-03-26

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

MHRA's patient-information modernisation and device advice refresh set a new evidence-operations baseline.

https://www.mattheneus.com/editorial/mhra-improving-patient-information-device-regulatory-advice-evidence-operations-playbook-2026-03-19

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

EMA Management Board ePI roadmap turns product-information governance into an HTA evidence operations priority.

https://www.mattheneus.com/editorial/ema-management-board-epi-roadmap-evidence-operations-playbook-2026-03-14

#HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Governance gets stronger when patient and consumer voice is formalized early in HTA. https://www.mattheneus.com/editorial/hta-consumer-panel-governance-playbook-singapore-ace-2026-03-29 #HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

EMA weekly PIP and PSUSA cadence is now an evidence-maintenance signal, not admin noise. https://www.mattheneus.com/editorial/ema-pip-psusa-weekly-cadence-evidence-maintenance-playbook-2026-03-10 #HTA #MAIC #EvidenceSynthesis #RegulatoryAffairs

CADTH Reimbursement Reviews: ITC and NMA Evidence Standards for Canadian Market Access. https://www.mattheneus.com/editorial/cadth-reimbursement-review-itc-nma-evidence-standards-canada-market-access-playbook-2026-03-26 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

Top-journal NMA quality gaps now demand transitivity-first governance in HTA evidence programs

https://www.mattheneus.com/editorial/nma-reporting-rigor-top-medical-journals-transitivity-governance-playbook-2026-03-24

#HTA #NMA #MAIC #EvidenceSynthesis #Pharma

Adaptive trial outputs are colliding with economic modelling timelines: an HTA evidence governance playbook https://www.mattheneus.com/editorial/adaptive-trial-to-economic-model-lineage-hta-evidence-governance-playbook-2026-03-23 #HTA #NMA #MAIC #HealthEconomics #EvidenceSynthesis

Cross-country HTA evidence transfer is now a credibility bottleneck: a new 2026 review finds inverse-odds weighting dominates practice while true transportability remains limited. What’s your governance plan for target-population assumptions? https://www.mattheneus.com/editorial/hta-transportability-iosw-cross-country-evidence-transfer-playbook-2026-03-23 #HTA #MAIC #NMA #EvidenceSynthesis #RWE

IQWiG reports added benefit not proven for lisocabtagene maraleucel in relapsed or refractory mantle cell lymphoma. https://www.mattheneus.com/editorial/iqwig-lisocabtagene-maraleucel-mcl-added-benefit-not-proven-unanchored-maic-2026-03-16 #HTA #MAIC #EvidenceSynthesis #Pharma

Cross-domain NMA transitivity stress-testing: a March 2026 playbook for decision teams https://www.mattheneus.com/editorial/cross-domain-nma-transitivity-stress-testing-playbook-2026-03-16 #HTA #NMA #MAIC #RegulatoryAffairs #EvidenceSynthesis

Depression HTA decisions can fail when outcome scales are misaligned across trials—this playbook shows how to keep ITC/NMA comparisons decision-grade. https://www.mattheneus.com/editorial/depression-outcome-measurement-heterogeneity-itc-nma-comparability-playbook-2026-03-15 #HTA #NMA #MAIC #EvidenceSynthesis #RWE

New editorial: NICE TA1121 recommends acoramidis and formalises a comparator-bridge evidence standard in transthyretin cardiomyopathy
https://www.mattheneus.com/editorial/nice-acoramidis-ta1121-recommendation-maic-comparator-bridge-2026-03-15
#HTA #MAIC #EvidenceSynthesis #Pharma

New HTA brief: SMC accepts Alyftrek for restricted NHSScotland use, with evidence lineage anchored in active-comparator CFTR-modulator studies

https://www.mattheneus.com/editorial/smc-alyftrek-restricted-acceptance-cftr-modulator-active-comparator-lineage-2026-03-14

#HTA #NMA #MAIC #EvidenceSynthesis #RWE

SMC submission-route mix in March 2026 signals a four-lane evidence architecture for faster HTA readiness

https://www.mattheneus.com/editorial/smc-submission-type-routing-evidence-readiness-playbook-2026-03-14

#HTA #NMA #MAIC #EvidenceSynthesis

Anchored comparator discipline is becoming the differentiator for HTA-ready indirect evidence this year. https://www.mattheneus.com/editorial/anchored-itc-common-comparator-governance-playbook-2026-03-14
#HTA #MAIC #NMA #EvidenceSynthesis #RegulatoryAffairs

SMC acceptance in grade 2 glioma sharpens the evidence signal for earlier treatment sequencing discussions. https://www.mattheneus.com/editorial/smc-vorasidenib-voranigo-acceptance-grade2-glioma-phase3-lineage-2026-03-09 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

PRAC safety updates can ripple into access strategy faster than most teams expect. https://www.mattheneus.com/editorial/ema-ixchiq-prac-aseptic-meningitis-product-information-update-2026-03-12 #HTA #NMA #MAIC #EvidenceSynthesis #RegulatoryAffairs

AbangeLabs ITC Studio: From MAIC-Centric Workflow to a Three-Ecosystem ITC Architecture. https://www.mattheneus.com/editorial/abangelabs-itc-studio-three-ecosystem-upgrade-executive-overview-2026-03-13 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

AI reporting lineage controls are becoming the decisive factor for HTA-ready evidence synthesis. https://www.mattheneus.com/editorial/ai-reporting-lineage-controls-hta-evidence-readiness-playbook-2026-03-12 #HTA #NMA #MAIC #EvidenceSynthesis #Pharma

This was a huge work that we just got published on trends and patterns in evidence synthesis within the field of Forestry and Forest-based Sector (F&FS) . The study investigates potential biases in evidence synthesized by examining different forms of synthesis (i.e. systematic and non-systematic), topics covered and geographical distribution of underpinning studies.
Reviewed topics are dominated by #ForestManagement, #Biodiversity and #ClimateChange, even though the field is sprawling away from core silviculture themes and into more transdisciplinary issues.
https://kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2Fauthors.elsevier.com%2Fsd%2Farticle%2FS1389-9341(25)00272-2/1/0102019bb8f33f70-22cdeb05-eff2-4afb-8f03-b9eb7a3813b3-000000/ERe2uC45FU6T7aRnqe4DgN9NIdQ=460
#bibliometrics #Forests #Forestry #ForestResearch #ForestBasedSector #EvidenceSynthesis
#AcademicChatter

And here it is: where you can request free access to Policy Commons to search for #GreyLit for an #EvidenceSynthesis project:
https://docs.google.com/forms/d/e/1FAIpQLSe8qQKZ6lvye6ZKD0wh0TInKOoBulPOynnxdcpo5qzsz1QIug/viewform

Just learned about the Result Assessment Tool (RAT)

Is anyone using this for #GreyLit in #EvidenceSynthesis #systematicreviews ?
#medlibs

In June I'm doing a free webinar: "Information retrieval for evidence synthesis: How researchers in limited-resource environments can do comprehensive searches"

https://www.campbellcollaboration.org/news-and-events/events/campbell-events/campbell-webinar-series-2023.html

Please sign up, and tell your #EvidenceSynthesis / #SystematicReview friends!
#medlibs #libraries #OpenAccess #LMIC #ResearchCapacity

In June I'm doing a free webinar: "Information retrieval for evidence synthesis: How researchers in limited-resource environments can do comprehensive searches"

https://www.campbellcollaboration.org/news-and-events/events/campbell-events/campbell-webinar-series-2023.html

Please sign up, and tell your #EvidenceSynthesis / #SystematicReview friends!
#medlibs #libraries #OpenAccess #LMIC #ResearchCapacity

In June I'm doing a free webinar: "Information retrieval for evidence synthesis: How researchers in limited-resource environments can do comprehensive searches"

https://www.campbellcollaboration.org/news-and-events/events/campbell-events/campbell-webinar-series-2023.html

Please sign up, and tell your #EvidenceSynthesis / #SystematicReview friends!
#medlibs #libraries #OpenAccess #LMIC #ResearchCapacity

In June I'm doing a free webinar: "Information retrieval for evidence synthesis: How researchers in limited-resource environments can do comprehensive searches"

https://www.campbellcollaboration.org/news-and-events/events/campbell-events/campbell-webinar-series-2023.html

Please sign up, and tell your #EvidenceSynthesis / #SystematicReview friends!
#medlibs #libraries #OpenAccess #LMIC #ResearchCapacity

In June I'm doing a free webinar: "Information retrieval for evidence synthesis: How researchers in limited-resource environments can do comprehensive searches"

https://www.campbellcollaboration.org/news-and-events/events/campbell-events/campbell-webinar-series-2023.html

Please sign up, and tell your #EvidenceSynthesis / #SystematicReview friends!
#medlibs #libraries #OpenAccess #LMIC #ResearchCapacity

Serious question: why would someone *want* to do an #EvidenceSynthesis project - #ScopingReview, #SystematicReview, #RapidReview, whatever - without writing a good protocol?
You're going to have to write up the methods *eventually* so why not do it now as you are starting, and get all the project management/clear communication benefits?
#medlibs @medlibs