#tumorimmunology — Public Fediverse posts

'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.'
#Immunology #TumorImmunology #Tregs #Immunotherapy

https://www.pnas.org/doi/10.1073/pnas.2404916121

Tumor Immunology/Immunotherapy at Wash U @RPachynski

Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!

https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982

#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982

'In this issue of Nature Medicine, Cascone et al.2share the latest results of their phase 2 platform trial, NEOSTAR, which suggest that the addition of CTLA-4 blockade to neoadjuvant anti-PD-1 plus chemotherapy may augment anti-tumor responses.'

#LungCancer #Immunology #TumorImmunology #immunotherapy #checkpointinhibitors

https://www.nature.com/articles/s41591-023-02246-2

STING maintains cells with metastatic potential in a dormant state in a mouse LUAD model.
#Immunology #TumorImmunology #CancerImmunity

https://www.nature.com/articles/s41586-023-05880-5

Tumor Immunology/Immunotherapy at Wash U @RPachynski

Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!

https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40536

#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40536

Tumor Immunology/Immunotherapy at Wash U @RPachynski

Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!

https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40518

#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40518

New publication alert in Cancer Discovery (@[email protected]) of a study my colleagues of Lead Pharma and I were involved in! Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha; see https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0244/716349/Discovery-of-Targets-for-Immune-Metabolic, in cooperation with Avinash Sahu, Xiaoman Wang, @[email protected], @[email protected], Keith Flaherty et al, and my colleagues and me at Lead Pharma. #cancerresearch #cancer #tumorimmunology #targetdiscovery #drugdevelopment #immunometabolism #tumormetabolism

#cartcells #cartcelltherapy #immunotherapy #genetherapy #IO #stemcell #stemcells #tumors #tumor #tumorimmunology #immunology

"Differing from its predecessor, ENLIGHT has been designed and evaluated with two real-world clinical scenarios in mind: personalized oncology, where one matches the best treatment to a patient based on a fixed decision threshold, and CTD, where the goal is to a priori exclude non-responding patients in the best possible manner. "

#immunotherapy #Immunology #TumorImmunology #Biomarker #PersonalisedMedicine

https://www.cell.com/med/fulltext/S2666-6340(22)00455-X#secsectitle0105