Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade.
#TcellExhaustion #CheckpointBlockade #TumorImmunology #CD8Tcells #AntiPD1 #Tpex #ImmuneCheckpoint #CancerImmunotherapy
#tumorimmunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tumorimmunology, aggregated by home.social.
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New Visualization: PD-1 Surface Expression Across CD8+ TIL Differentiation States
I am sharing a violin-style visualization intended to communicate a well-established mechanistic trend in tumor immunology.
#TumorImmunology #TCellExhaustion #DataVisualization #PD1 #FlowCytometry
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Sharing a visualization from a conceptual synthesis of the CD8+ T cell terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes.
Figure: "Transcriptional and Epigenetic Architecture of CD8+ T Cell Exhaustion"
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T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356 -
'They identified the 11 most frequently occurring CD4TCRs in mice bearing an autochthonous tumor line. Three TCRs showed evidence of convergent evolution, because T cell clonotypes had different nucleotide sequences but identical TCR α and β chains.'
#Immunology #TumorImmunology #Immunology
https://www.science.org/doi/10.1126/sciimmunol.adp6529 -
"Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as type 1 conventional dendritic cells"
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'Here, we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition to treatment-naive glioblastoma tumors, harbors active lymphoid populations at the time of initial diagnosis'
#Immunology #TumorImmunology -
'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.'
#Immunology #TumorImmunology #Tregs #Immunotherapy -
"Together, our data indicate that GLUT10 is selectively required for glucose uptake of CD8+ T cells and identify that TME accumulated lactic acid inhibits CD8+ T cell effector function by directly binding to GLUT10 and reducing its glucose transport capacity. Last, our study suggests disrupting lactate-GLUT10 binding as a promising therapeutic strategy to enhance CD8+ T cell–mediated antitumor effects."
#Immunology #TumorImmunology #Immunotherapy https://www.science.org/doi/10.1126/scitranslmed.adk7399 -
'Late tumors repressed antitumor immunity genes, reducing infiltrating immune cells & tumor–immune cell communications. Innate immune genes, especially interferon-stimulated genes, dominated the list of downregulated tumor genes'
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'The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy.'
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'Herein, we describe a synapse formation between α-SMA+ CAFs and regulatory T cells (Tregs) in the TME. Foxp3+ Tregs were localized close to α-SMA+CAFs in diverse types of tumor models as well as biopsies from melanoma and colorectal cancer patients.'
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'Here, we use photo-labeling, combined with longitudinal transcriptomic and cellular analyses, to interrogate the fate of intratumoral NK cells. We reveal that NK cells rapidly lose effector functions and adopt a distinct phenotypic state with features associated with tissue residency.'
#Immunology #TumorImmunology #immunotherapy -
"Chronic viral infections are known to accelerate immune aging and to induce immune senescence (21, 22). We have shown that among 206 viruses with human tropism, only CMV seropositivity was associated with senescence of CD8+ T cells in patients with aNSCLC."
#Immunology #TumorImmunology #Immunotherapy -
"Animals lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses, showing that microglia are critical to promote anti-tumour immunity to suppress breast cancer brain metastasis."
#Immunology #TumorImmunology #Microglia -
Cool #neuroimmunology paper, linking stress with exhastion of CD8 T cells...
#immunology #chronic #infection #tumorimmunology -
'A single intramuscular injection of Lenti-HPV-07 into mice bearing established HPV-induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases.'
#TumorImmunology #Immunology #immunotherapy
Douguet et al @EmboMolMed -
'Here, we show in multiple cancer models that CXCR3+ Treg cells were increased in tumors compared with lymphoid tissues, exhibited an activated phenotype, and interacted preferentially with CXCL9-producing BATF3+ dendritic cells (DCs). Genetic ablation of CXCR3 in Treg cells disrupted DC1-Treg cell interactions and concomitantly increased DC-CD8+ T cell interactions.'
#Immunology #TumorImmunology #immunotherapy
https://www.cell.com/immunity/fulltext/S1074-7613(23)00260-1
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When discussing the role of microbiome in modulating immune responses to tumours, I did not expect that to require the actual bacteria translocating to the tumour!
#TumorImmunology #medicine #immunity #immunology #melanoma
@cellpress
https://www.cell.com/cell/fulltext/S0092-8674(23)00271-4?dgcid=raven_jbs_etoc_email -
Cool work from Michael Fischbach & collaborators: engineering skin bacteria to express tumoral antigens induces protective T cell responses - including at distal sites (in mice).
#immunology #immunotherapy #TumorImmunology -
'Thus, identifying the subset of patients for whom public neoantigens are relevant targets is a major challenge. Nevertheless, the ability provided by the expansion of standard-of-care next-generation sequencing to screen patients affords the opportunity for off-the-shelf precision immunotherapies against public neoantigens that would be broadly applicable to many patients and would have tremendous advantages in scalability relative to targeting private neoantigens'
#Immunology #Immunotherapy #TumorImmunology -
Tumor Immunology/Immunotherapy at Wash U @RPachynski
Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!
#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982 -
'In this issue of Nature Medicine, Cascone et al.2share the latest results of their phase 2 platform trial, NEOSTAR, which suggest that the addition of CTLA-4 blockade to neoadjuvant anti-PD-1 plus chemotherapy may augment anti-tumor responses.'
#LungCancer #Immunology #TumorImmunology #immunotherapy #checkpointinhibitors
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"Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity."
#Immunology #TumorImmunology #Immunotherapy #Metabolism
#InnateImmunity -
STING maintains cells with metastatic potential in a dormant state in a mouse LUAD model.
#Immunology #TumorImmunology #CancerImmunity -
"Thus, we performed a comprehensive screen of TE-chimeric transcripts across 10,357 tumors, 675 cancer cell lines and 11,686 Genotype-Tissue Expression (GTEx) adult tissues, and evaluated these TE-chimeric candidates for tumor specificity, antigenic potential, proteomic validation, HLA presentation and membrane presence."
#TumorImmunology #immunology -
"The induction of cellular cytotoxicity requires that the NK cell contacts its target cell and establishes a lytic immunological synapse. Previous reports have revealed that membrane protrusions may be a component of immune synapses. Here, we explored whether changes in the topology of intratumoral NK cell membranes relate to the formation of lytic immunological synapses."
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"Here we show that metabolic conditioning of CD8+ effector T cells induces an oxidized cellular redox balance at least in part mediated by increased mitochondrial reactive oxygen species (ROS). This redox shift contributes to enhanced in vivo persistence and tumor clearance."
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Tumor Immunology/Immunotherapy at Wash U @RPachynski
Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!
#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40536 -
Tumor Immunology/Immunotherapy at Wash U @RPachynski
Come join the Pachynski Lab and study #prostatecancer #immunotherapy and #tumorimmunology !!
#ScienceJobs #job #postdoc #postdocjobs #postdocpositions #immunotherapy @Si...
https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=40518 -
New publication alert in Cancer Discovery (@[email protected]) of a study my colleagues of Lead Pharma and I were involved in! Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha; see https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0244/716349/Discovery-of-Targets-for-Immune-Metabolic, in cooperation with Avinash Sahu, Xiaoman Wang, @[email protected], @[email protected], Keith Flaherty et al, and my colleagues and me at Lead Pharma. #cancerresearch #cancer #tumorimmunology #targetdiscovery #drugdevelopment #immunometabolism #tumormetabolism
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This March the Dutch Society for Immunology (DSI/NVVI) host the NVVI Spring Meeting. We host inspiring talks on many topics in #Immunology: #Infection, #Modeling, #Neuroscience, #Cytokines, #TumorImmunology.
It's a relatively small meeting, so you have plenty of opportunities to meet the speakers and other participants.Early bird registration ends February 16th.
More information:
https://www.nvvi-dsi.nl/events2/sring-symposium-2023 -
Looking to connect with anybody interested in #tumorimmunology and #invivobiology 👀🤓🐭🧬