#immunecheckpoint — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunecheckpoint, aggregated by home.social.
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Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.
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Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.