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#immunometabolism — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #immunometabolism, aggregated by home.social.

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  1. The latest collection of commentary and Essays in @PLOSBiology is devoted to #immunometabolism.

    We highlight how the interplay between systemic metabolism and the immune response impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism.

    ⚛️ Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches as discovery tools for new therapeutic targets

    💉 Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in metabolism can affect tissue-resident immune cells

    🦠 Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on lung pathogens

    🥗 On a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to target immunometabolism through pharmaceutical and lifestyle interventions, with a focus on cancer

    The collection was edited by Claudio Mauro, Lucas Smith and Joanna Clarke

    #immunology #metabolism #cancer #aging #inflammation #infection

    collections.plos.org/collectio

  2. Immunometabolism describes more than just metabolic shifts in immune cells. Our new collection of articles shines a light on the many facets of #immunometabolism, exploring the effects of molecular, cellular, and systemic metabolic mechanisms in health and disease.
    #immunology #metabolism plos.io/4c5z6Cn

  3. Immunometabolism is often disrupted in #cancer, suggesting it could be useful target for therapy. Heidi Ling & colleagues explore the potential for incorporating #lifestyle changes and drug therapies that target #immunometabolism into treatments for cancer. plos.io/4jNASKk

  4. Nicole Chapman & Hongbo Chi @stjuderesearch highlight how systems biology approaches are being used to unravel the complex process of metabolic regulation of immune function and advance our understanding of #immunometabolism in our new #PLOSBiology Perspective.
    plos.io/4aR959z

  5. Metabolites from both host and pathogen can affect the severity and outcomes of #infection. In their new Essay, Alice Prince & Griffin Gowdy of
    @columbiamed discuss how the study of #immunometabolism has revealed the molecular mechanisms underlying bacterial pulmonary infections
    plos.io/4jpVnNb

  6. CW: The Aldehyde Hypothesis | Heran Darwin

    NIH presentation, Sept 27, 2023
    youtu.be/zLkq6a_W1nE?si=1GTVQA

    Reactive aldehydes enhance the antimicrobial effect of nitric oxide - possibly an explanation for the maintenance of ALDH2* in Asian populations.
    Acetaldehyde doesn't work - so drinking alcohol won't help treat TB infection.
    Warburg Effect - anaerobic glycolysis produces aldehydes (methylglyoxal) [22:12, 54:26].

    #ALDH2 #NitricOxide
    #Tuberculosis
    #Microbiology
    #Immunology #malondialdehyde #methylglyoxal #metabolism #WarburgEffect #Immunometabolism
    #AldehydeHypothesis

  7. New publication alert in Cancer Discovery (@[email protected]) of a study my colleagues of Lead Pharma and I were involved in! Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha; see aacrjournals.org/cancerdiscove, in cooperation with Avinash Sahu, Xiaoman Wang, @[email protected], @[email protected], Keith Flaherty et al, and my colleagues and me at Lead Pharma. #cancerresearch #cancer #tumorimmunology #targetdiscovery #drugdevelopment #immunometabolism #tumormetabolism

  8. Updated #introduction time. I’m a postdoctoral research associate at the University of Glasgow, interested in energy homeostasis and sickness behaviour 
Research interests include #adipocytes #adiposetissue #metabolism #immunometabolism #immunity and #IL-17 ! 
I also founded The STEM Village, an initiative to promote visibility of #LGBTQ people in #STEM 🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️ you can find out more on our website thestemvillage.com or our #YouTube channel youtube.com/@thestemvillage309

  9. #Introduction time. I’m a postdoctoral research associate at the University of Glasgow
Research interests include #adipocytes #adiposetissue #metabolism #immunometabolism #immunity and #IL-17 ! 
I also founded The STEM Village, an initiative to promote visibility of #LGBTQ people in #STEM 🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️🏳️‍🌈🏳️‍⚧️ you can find out more on our website thestemvillage.com or our #YouTube channel youtube.com/channel/UCULuHvpzP

  10. #introduction I’ve been reluctant to engage with yet another social media platform, but this seems as good as any to keep up with others’ #science, which I do enjoy!

    I’m a #postdoc at Penn (Microbiology) working with @SunnyShinLab. My research interests include #immunometabolism, #InnateImmunity, and #HostDefense in the lung. I’m also passionate about #education, #mentorship, #MentalHealth, and #DEI in STEM.

    When not in lab, I’m either running and/or listening to the latest hard rock album!

  11. #Immunology #Metabolism #ImmunoMetabolism

    "Here, we reviewed a T Cell Receptor (TCR)-primed environmental cue-boosted model of adipose Treg cells’ tissue adaptation, especially in response to IL-33, IFN-α, insulin and androgen signals, which trigger sophisticated transcriptional cascades and ultimately establish unique transcriptional modules in adipose Treg cell subsets."

    onlinelibrary.wiley.com/doi/ab

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