#trpchannels — Public Fediverse posts

@BenjaminHCCarr

quote from article:
"Notably, 10 of the 19 individuals who reported that they were pregnant when exposed [to tear gas] reported a subsequent miscarriage — that’s about twice the expected rate of miscarriage. "

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tear gas (2-chlorobenzalmalononitrile [CS]) targets TRPA1

pepper spray (oleoresin capsicum [OC], capsaicin) targets TRPV1

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"Although TRPV1 and TRPA1 have been shown in the human eutopic and ectopic endometrium, their regulation and functional importance are not known..."
https://doi.org/10.1530/JME-15-0184

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"CS exposure induced strong tissue swelling, plasma extravasation, and a dramatic increase in inflammatory cytokine levels in the mouse ear skin. We also showed that the effects of CS were not transient but caused persistent skin injuries. These injury parameters were reduced with TRPA1 inhibitor treatment. Further, we tested the pharmacologic activity of advanced TRPA1 antagonists in vitro. Our findings showed that TRPA1 is a crucial mediator of CS-induced nociception and tissue injury and that TRPA1 inhibitors are effective countermeasures that reduce key injury parameters when administered after exposure. "
https://doi.org/10.1124/jpet.123.001666

#TRPchannels #nocicieption
#TearGas

#ProteinEngineering #TRPChannels #SyntheticBiology #VisionRestoration #Retina #GeneTherapy

Study offers a potential pathway for safer, non-addictive pain management

https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx

"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."

They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -

Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y

#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

https://doi.org/10.1177/0960327119877460

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014

#ALDH2 #TRPV1 #TRPchannels #mitochondria #ToRead

Today's reading topic to distract/entertain/self-soothe -

Would messing with ankyrin mess up both Piezo and TRP channel function? What would be the implications for immune function?

articles to read:

Human ankyrins and their contribution to disease biology: An update
https://www.ias.ac.in/article/fulltext/jbsc/045/0146

Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus
https://doi.org/10.1152/ajpcell.00368.2020

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822220/

Roles of TRP and PIEZO receptors in autoimmune diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140548/

okay, that should be enough

also an hour of body scan meditation
& some Perilla tea

#TRPchannels #Piezo #ENaC #ankyrin #autoimmunity #ImmuneSystem

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/

#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption