#trpchannels — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #trpchannels, aggregated by home.social.
-
more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint] -
more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint] -
quote from article:
"Notably, 10 of the 19 individuals who reported that they were pregnant when exposed [to tear gas] reported a subsequent miscarriage — that’s about twice the expected rate of miscarriage. "~
tear gas (2-chlorobenzalmalononitrile [CS]) targets TRPA1pepper spray (oleoresin capsicum [OC], capsaicin) targets TRPV1
~
"Although TRPV1 and TRPA1 have been shown in the human eutopic and ectopic endometrium, their regulation and functional importance are not known..."
https://doi.org/10.1530/JME-15-0184~
"CS exposure induced strong tissue swelling, plasma extravasation, and a dramatic increase in inflammatory cytokine levels in the mouse ear skin. We also showed that the effects of CS were not transient but caused persistent skin injuries. These injury parameters were reduced with TRPA1 inhibitor treatment. Further, we tested the pharmacologic activity of advanced TRPA1 antagonists in vitro. Our findings showed that TRPA1 is a crucial mediator of CS-induced nociception and tissue injury and that TRPA1 inhibitors are effective countermeasures that reduce key injury parameters when administered after exposure. "
https://doi.org/10.1124/jpet.123.001666 -
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman -
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman -
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman -
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman -
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
-
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
-
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
-
research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014 -
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
-
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
-
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
-
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
-
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
-
Today's reading topic to distract/entertain/self-soothe -
Would messing with ankyrin mess up both Piezo and TRP channel function? What would be the implications for immune function?
articles to read:
Human ankyrins and their contribution to disease biology: An update
https://www.ias.ac.in/article/fulltext/jbsc/045/0146Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus
https://doi.org/10.1152/ajpcell.00368.2020Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822220/Roles of TRP and PIEZO receptors in autoimmune diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140548/okay, that should be enough
also an hour of body scan meditation
& some Perilla tea#TRPchannels #Piezo #ENaC #ankyrin #autoimmunity #ImmuneSystem
-
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
-
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
-
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
-
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
-
CW: Erythromelalgia, pain, SCN9A / Nav1.7
I should probably mention that like the woman in 1st case report, I also have MCAS symptoms, as well as other pain and paresthesia in my hands and elsewhere. I had a colonoscopy a few months after this started and for the prep I ate mostly just white rice and tapioca - no fruit or veg. I felt much, much better on the colonoscopy prep diet. Since then my diet has become quite restricted as I noticed more pain when I ate cruciferous veg, alliums, legumes - lots of stuff.
So it is possible some of my erythromelalgia symptom improvement is due to having a limited diet - which is probably not so great for long term health overall.
I have wondered if there is TRP channel involvement since isothiocyanates and other food components can activate TRP channels, as can heat exposure.
Then there is the possibility of a connection to mast cells to consider.
-
CW: PHYSIOLOGY SHORTS: Antagonism of TRPV4 channels reduces mechanotransduction in rat skeletal muscle
"A mechanical stimulus to skeletal muscle activates the sympathetic nervous system during exercise. ... Our data suggests that TRPV4 plays an important role in mechanotransduction contributing to the cardiovascular responses during exercise. "
-
CW: Ultrasound Induces Torpor-Like State in Animals
news article:
https://www.sciencealert.com/ultrasound-induces-torpor-like-state-in-animals-experiment-shows"the ultrasound was activating the TRPM2 ion channel in neurons of the hypothalamus preoptic area, demonstrating this is an ultrasound-sensitive ion channel that plays a role in sending animals into
[ultrasound-induced hypothermia & hypometabolism]" -
CW: Ultrasound Induces Torpor-Like State in Animals
news article:
https://www.sciencealert.com/ultrasound-induces-torpor-like-state-in-animals-experiment-shows"the ultrasound was activating the TRPM2 ion channel in neurons of the hypothalamus preoptic area, demonstrating this is an ultrasound-sensitive ion channel that plays a role in sending animals into
[ultrasound-induced hypothermia & hypometabolism]"
