#trpm8 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #trpm8, aggregated by home.social.
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The study tested peppermint oil vs. Schweppes peppermint cordial as the placebo. The study authors state that since menthol is not listed on the ingredient list of the cordial, it did not contain menthol. The ingredient list* says it contains 'natural flavors' - do UK regulations preclude 'natural flavors' from containing menthol?
Does anyone know if Schweppes peppermint cordial elicits a cooling sensation?
I can't imagine a peppermint food item not doing so - it's kind of not peppermint if it doesn't.
Even if the cordial has a cooling effect, it may be too low a dose - so it wouldn't rule out TRPM8 activation as being the
mechanism for lowering BP and RHR.journal article:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0344538* Schweppes cordial ingredients (according to Spoonful):
https://spoonfulapp.com/products/schweppes-peppermint-flavour-cordial-1l/NTAwMDE5MzY0MDk4OQ==#NaturalProducts #FunctionalFoods #TRPM8 #BloodPressure #TRPchannels
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Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
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Moderate cold is sensed by #TRPM8 channels, but what about extreme cold?
Peter McNaughton, Tamara Buijs et al at Kings College London identify a #STIM1-#ORAI-mediated mechanism in sympathetic #neurons that may prevent #frostbite through cold‐induced#vasodilation
https://www.embopress.org/doi/10.15252/embj.2022111348