#aldh2 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #aldh2, aggregated by home.social.
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research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014 -
research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014 -
research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014 -
research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014 -
We have published several research articles along this line. It is one of my research projects that is purely based on my personal interest😉
Because acetaldehyde damages DNA, people (especially individual with heterozygous for this allele) shouldn't be drinking a lot. But people with homozygous for this mutation are not able to drink alcohol at all, so they never become alcoholic, which seems to be a positive effect🤔
#Alcohol #ALDH2 #Acetaldehyde #Drinking #Metabolism #Genetics
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Triple IPA - 11.5% alcohol 🤔
I like this bitterness and light citrus flavor. But I feel alcohol a lot, thinking about acetaldehyde, the primary metabolite of alcohol, although my enzyme (ALDH2) that detoxifies acetaldehyde has no mutation 😉
About half of East Asian people have a mutation in this enzyme. I am looking forward to seeing our kids’ genotypes 🤔#Alcohol #Acetaldehyde #Metabolism #Science #Genetics #AcetaldehydeDehydrogenase #ALDH2
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CW: The Aldehyde Hypothesis | Heran Darwin
NIH presentation, Sept 27, 2023
https://youtu.be/zLkq6a_W1nE?si=1GTVQAxEXAz4aT07Reactive aldehydes enhance the antimicrobial effect of nitric oxide - possibly an explanation for the maintenance of ALDH2* in Asian populations.
Acetaldehyde doesn't work - so drinking alcohol won't help treat TB infection.
Warburg Effect - anaerobic glycolysis produces aldehydes (methylglyoxal) [22:12, 54:26].#ALDH2 #NitricOxide
#Tuberculosis
#Microbiology
#Immunology #malondialdehyde #methylglyoxal #metabolism #WarburgEffect #Immunometabolism
#AldehydeHypothesis -
Some Long Covid symptoms, e.g., alcohol intolerance, could be due to lowered activity of aldehyde dehydrogenase, particularly ALDH2. I submitted a related hypothesis to the Patient-Led Hypothesis Generation Panel which provides background & refs (1).
Inhibition of aldehyde dehydrogenase causes lower sperm count & has been investigated as a means of male birth control (2).
1- https://docs.google.com/document/d/1XBe3xkZLUtcTUZjd07nH97jjL9QR5Vt3YS08zo7WpOY/edit?usp=sharing
2- https://www.bloomberg.com/news/features/2017-08-03/why-we-can-t-have-the-male-pill