#trpm3 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #trpm3, aggregated by home.social.
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more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint] -
more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint]