#ldn — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ldn, aggregated by home.social.
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more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint] -
more on LDN:
"The hypothesis may be broadened further in full consideration of work by Marshall-Gradisnik and colleagues [20]. They report that LDN restores function for one class of impaired calcium channels from the transient receptor potential (TRP) family
[21]. The specific channel (TRPM3) is
expressed on immune cells, which were isolated from ME patients to show in vitro dysfunction with rescue by LDN. On the surface, this heat-sensitive calcium channel appears unrelated to
microbiome-driven pathology in ME. However, a recent study reports that LPS activates several TRP channels, including TRPM3 [22] . As such, the bacterial microbiome conceivably plays an (as yet unelucidated) role in driving TRPM3 channelopathy seen in ME"-- Vijay Iyer, 2022, 'Efficacy of low-dose naltrexone (LDN) for ME/CFS arises via attenuation of
microbiome-driven pathology through its effects on bacterial pathogen-associated
molecular pattern (PAMP) receptor pathways' [preprint] -
CW: medical, glp1 (~ozempic) for medical reasons, LongCovid
She also said that taking LDN and glp1 at the same time isn't really an option. Eh. So now I don't know what to do. I guess I'll see what my friday appointment says.
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CW: medical, glp1 (~ozempic) for medical reasons, LongCovid
She also said that taking LDN and glp1 at the same time isn't really an option. Eh. So now I don't know what to do. I guess I'll see what my friday appointment says.
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CW: medical, glp1 (~ozempic) for medical reasons, LongCovid
She also said that taking LDN and glp1 at the same time isn't really an option. Eh. So now I don't know what to do. I guess I'll see what my friday appointment says.
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Hören 👉 #LageDerNation #LdN485
Der #MafiaStaat - Was ihr über #Russland wissen solltet
mit #GesineDornblüth, #Osteuropa-JournalistinWie unsere demokratischen Maßstäbe an der tief verwurzelten #GewaltKultur in der russischen Gesellschaft und dem #MafiaSystem auf allen Politikebenen zerschellen.
Wie #russische #Desinformation auf unserer #Friedenssehnsucht & romantisierenden Sicht auf Russland aufbaut.
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Hören 👉 #LageDerNation #LdN485
Der #MafiaStaat - Was ihr über #Russland wissen solltet
mit #GesineDornblüth, #Osteuropa-JournalistinWie unsere demokratischen Maßstäbe an der tief verwurzelten #GewaltKultur in der russischen Gesellschaft und dem #MafiaSystem auf allen Politikebenen zerschellen.
Wie #russische #Desinformation auf unserer #Friedenssehnsucht & romantisierenden Sicht auf Russland aufbaut.
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New from Spain:
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled...trial
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New from Spain:
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled...trial
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New from Spain:
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled...trial
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New from Spain:
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled...trial
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New from Spain:
Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled...trial
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Medscape:
“Low-dose naltrexone (LDN) failed to outperform placebo in reducing pain or improving secondary outcomes in women with fibromyalgia”
https://www.medscape.com/viewarticle/low-dose-naltrexone-fails-outperform-placebo-pain-2026a1000iy0 -
Medscape:
“Low-dose naltrexone (LDN) failed to outperform placebo in reducing pain or improving secondary outcomes in women with fibromyalgia”
https://www.medscape.com/viewarticle/low-dose-naltrexone-fails-outperform-placebo-pain-2026a1000iy0 -
@netbird
Im letzten #LdN Podcast wurde das gut analysiert. Viele Abgeordnete werden noch auf #XTwitter sein. Sie sind also der Meinung was da in der rechten Bubble gepostet wird, sei die Meinung 'der Bürger'.
Konsequenterweise müsste man in Bürgersprechstunden der MdBs gehen und ihnen sagen was wirklich ist.
@c_ozwei @chrisstoecker -
@netbird
Im letzten #LdN Podcast wurde das gut analysiert. Viele Abgeordnete werden noch auf #XTwitter sein. Sie sind also der Meinung was da in der rechten Bubble gepostet wird, sei die Meinung 'der Bürger'.
Konsequenterweise müsste man in Bürgersprechstunden der MdBs gehen und ihnen sagen was wirklich ist.
@c_ozwei @chrisstoecker -
#LdN: die #SozialstaatsReform macht Hoffnung!
sehr viel gute, aber teils total analoge Ideen! 🤦🏻♂️
#EinzelfallGerechtigkeit kann man problemlos herstellen: ein Computer hat kein Problem genau zu rechnen! Man muss ihn nur lassen!#DigitaleDisruption #AlexanderMarkowetz
“Die große Frage ist natürlich jetzt: schafft Deutschland die Umsetzung?
Weil natürlich mit einer Pauschalierung einhergeht, das nicht jeder Fall im Detail gerecht behandelt werden kann”https://podcasts.apple.com/podcast/id1092957894?i=1000747061017&r=2680&t=2763
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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Es wurden folgende Wirkstoffe von der "Expertengruppe Long COVID Off-Label-Use" positiv bewertet:
- Agomelatin
- Ivabradin
- Naltrexon (Low Dose)
- Vortioxetin
- MetforminDas Ergebnisprotokoll der 11. Sitzung der Expertengruppe am 02.04.2025 kann hier eingesehen werden: https://www.bfarm.de/DE/Arzneimittel/Zulassung/Zulassungsrelevante-Themen/Expertengruppe-Long-COVID-Off-Label-Use/Protokolle/EP_11-Sitzung_02-04-2025.html?nn=1628850
#OffLabelUse #MECFS #LongCovid #OffLabel #Expertengruppe #BfArM #Therapie #LDN #Metformin #Vortioxetin #Agomelatin #Ivabradin
2/2 -
Es wurden folgende Wirkstoffe von der "Expertengruppe Long COVID Off-Label-Use" positiv bewertet:
- Agomelatin
- Ivabradin
- Naltrexon (Low Dose)
- Vortioxetin
- MetforminDas Ergebnisprotokoll der 11. Sitzung der Expertengruppe am 02.04.2025 kann hier eingesehen werden: https://www.bfarm.de/DE/Arzneimittel/Zulassung/Zulassungsrelevante-Themen/Expertengruppe-Long-COVID-Off-Label-Use/Protokolle/EP_11-Sitzung_02-04-2025.html?nn=1628850
#OffLabelUse #MECFS #LongCovid #OffLabel #Expertengruppe #BfArM #Therapie #LDN #Metformin #Vortioxetin #Agomelatin #Ivabradin
2/2 -
Es wurden folgende Wirkstoffe von der "Expertengruppe Long COVID Off-Label-Use" positiv bewertet:
- Agomelatin
- Ivabradin
- Naltrexon (Low Dose)
- Vortioxetin
- MetforminDas Ergebnisprotokoll der 11. Sitzung der Expertengruppe am 02.04.2025 kann hier eingesehen werden: https://www.bfarm.de/DE/Arzneimittel/Zulassung/Zulassungsrelevante-Themen/Expertengruppe-Long-COVID-Off-Label-Use/Protokolle/EP_11-Sitzung_02-04-2025.html?nn=1628850
#OffLabelUse #MECFS #LongCovid #OffLabel #Expertengruppe #BfArM #Therapie #LDN #Metformin #Vortioxetin #Agomelatin #Ivabradin
2/2 -
Es wurden folgende Wirkstoffe von der "Expertengruppe Long COVID Off-Label-Use" positiv bewertet:
- Agomelatin
- Ivabradin
- Naltrexon (Low Dose)
- Vortioxetin
- MetforminDas Ergebnisprotokoll der 11. Sitzung der Expertengruppe am 02.04.2025 kann hier eingesehen werden: https://www.bfarm.de/DE/Arzneimittel/Zulassung/Zulassungsrelevante-Themen/Expertengruppe-Long-COVID-Off-Label-Use/Protokolle/EP_11-Sitzung_02-04-2025.html?nn=1628850
#OffLabelUse #MECFS #LongCovid #OffLabel #Expertengruppe #BfArM #Therapie #LDN #Metformin #Vortioxetin #Agomelatin #Ivabradin
2/2 -
Dokieli's ( https://dokie.li/ ) Share feature now includes:
* granting and changing access controls;
* copy URL to clipboard;
* sending notifications to contacts' inbox about the article.Screencast: https://dokie.li/media/video/dokieli-share.webm
Implements:
* https://solidproject.org/TR/protocol
* https://solidproject.org/TR/wac
* https://www.w3.org/TR/ldn/
* https://www.w3.org/2005/Incubator/webid/spec/identity/Source: https://github.com/dokieli/dokieli
#SolidProject #SolidProtocol #WAC #WebAccessControl #LinkedDataNotifications #LDN #ActivityStreams #WebID
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📣 We are pleased sponsors of 26th April #R Dev Day at Imperial College #LDN. 📊🔬🚀
This 🆓 satellite event to our #SatRdays conference(27th), is a platform to learn about contributing & opportunity to collaborate in base R.👨💻 👩💻
🥳🥳 Registered participants receive a 💫 40% SatRdays DISCOUNT CODE🎊🎉 on the 27th.🎡 🇬🇧
Don't miss out! Get Your Tickets 🎟️ & 40% Discount Now⬇️
#RStats #datascience #ai #machinelearning #programming #rprogramming #londonevent #python
https://www.meetup.com/r-contributors/events/299810000/ -
📣 We are pleased sponsors of 26th April #R Dev Day at Imperial College #LDN. 📊🔬🚀
This 🆓 satellite event to our #SatRdays conference(27th), is a platform to learn about contributing & opportunity to collaborate in base R.👨💻 👩💻
🥳🥳 Registered participants receive a 💫 40% SatRdays DISCOUNT CODE🎊🎉 on the 27th.🎡 🇬🇧
Don't miss out! Get Your Tickets 🎟️ & 40% Discount Now⬇️
#RStats #datascience #ai #machinelearning #programming #rprogramming #londonevent #python
https://www.meetup.com/r-contributors/events/299810000/ -
Jarred Younger:
A large remote clinical trial grant on low-dose naltrexone ( #LDN ) & cannabidiol ( #CBD ) for #GulfWarIllness was rejected. If you want to hear a bit about how I feel about rejected grants & how I handle them...https://www.youtube.com/watch?v=9fkfvFIDyWI
@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #GWI @fibromyalgia
#Fibromyalgia #Fibro #FMS #FM -
Jarred Younger:
A large remote clinical trial grant on low-dose naltrexone ( #LDN ) & cannabidiol ( #CBD ) for #GulfWarIllness was rejected. If you want to hear a bit about how I feel about rejected grants & how I handle them...https://www.youtube.com/watch?v=9fkfvFIDyWI
@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #GWI @fibromyalgia
#Fibromyalgia #Fibro #FMS #FM
