#nejm — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #nejm, aggregated by home.social.
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I don't think I can recall one such paper from #NEJM, before this.
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Update. Three past editors of the New England Journal of Medicine (#NEJM) answer the attack on their journal from #RFKJr.
https://www.statnews.com/2025/06/30/rfk-jr-medical-journals-nejm-jama-lancet-editors-respond-medical-journals-ethics/
(#paywalled)"Kennedy claimed that one of us (Angell) said, 'We are no longer a science journal, we are a vessel for pharmaceutical propaganda.' In fact, what Angell said in a 2009 article was that 'it is simply no longer possible to believe much of the clinical research that is published,' due to researchers’ financial ties with pharmaceutical companies."
The editors also point out that the three journals named by Kennedy happen to have published editorials criticizing the #Trump admin assault of science.
#DefendResearch #Medicine #Pharma #ScholComm #TrumpVResearch #USPol #USPolitics
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Un nuevo agonista selectivo de los receptores tipo 2 de #Orexina que se administra por vía oral es eficaz para combatir la #narcolepsia, e incluso llega a causar #insomnio como efecto colateral 😄
#Oveporexton #Narcolepsy #Orexin #Neurology #Neurología #SleepMedicine #MedicinaDelDormir #NEJM
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It reminds me of #AtlasShrugged.
“We are probably going to stop publishing in the Lancet, the New England Journal of Medicine (#NEJM), #JAMA and those other journals because they are all corrupt."
Kennedy said agencies within the #HHS will create their own “in-house” journals. “They are going to become the preeminent journals, because if you get #NIH funding it is anointing you as a good, legitimate scientist,” he said.
https://thehill.com/policy/healthcare/5322269-robert-kennedy-jr-bans-medical-journals/
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"Robert F. Kennedy Jr., the nation’s health secretary, singled out N.E.J.M in an interview with the “Dr. Hyman Show” podcast last year as an example of a medical journal that has participated in “lying to the public” and “retracting the real science.”
. . .“I’m going to litigate against you under the racketeering laws, under the general tort laws,” he said. “I’m going to find a way to sue you unless you come up ...”"
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#RFKJr, #Trump’s *#health* secy, singled out #NEJM in an interview w/the “Dr. Hyman Show” podcast last year as an example of a #medical journal that has participated in “lying to the public” & “retracting the real science.”
Andrew Nixon, a spox for the #HHS, declined to comment on whether RFKJr had any involvement w/the letters.
In the interview, RFKJr said he would seek to prosecute medical journals under federal anti-corruption laws.
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Amanda Shanor, a #FirstAmendment expert at the University of Pennsylvania, said the information published in reputable #medical journals like #NEJM is broadly protected by the #Constitution.
In most cases, journals have the same robust rights that apply to newspapers — the strongest the Constitution provides, she added.
#law #censorship #democracy #Trump #AbuseOfPower #authoritarianism #tyranny #dictatorship #AntiIntellectualism #science #medicine
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Do they accept submissions from scientists with “competing viewpoints”? What do they do if the authors whose work they published “may have misled their readers”? Are they transparent about influence from “supporters, funders, advertisers & others”?
News of the letter to #NEJM was reported earlier by STAT, a health news outlet.
#EdMartin also asked about the role of the #NIH, which funds some of the #research the journals publish, & the agency’s role “in the development of submitted articles.”
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A federal prosecutor in Washington has contacted The New England Journal of Medicine, considered the world’s most prestigious #medical journal, w/questions that suggested without evidence that it was biased against certain views & influenced by external pressures.
Dr. Eric Rubin, the editor in chief of #NEJM, described the letter as “vaguely threatening” in an interview with NYT.
#law #censorship #FirstAmendment #Constitution #Trump #AbuseOfPower #AmericanAutocracy #tyranny #science #medicine
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Madness #AmericanAutocracy
‘Vaguely Threatening’: #Trump Federal Prosecutor #EdMartin Queries Leading #Medical Journal
The New England Journal of Medicine [#NEJM] received a letter suggesting that it was biased & compromised by external pressure. Other journals have also received the letter.
#law #censorship #FirstAmendment #Constitution #democracy #AbuseOfPower #authoritarianism #tyranny #dictatorship #AntiIntellectualism #science #medicine
https://www.nytimes.com/2025/04/25/health/nejm-prosecutor-letter.html?smid=nytcore-ios-share&referringSource=articleShare&sgrp=p&pvid=68CE025A-703F-4C94-87AA-8D0D7D06D23B -
Not Surprising: Endovascular treatment (EVT) is beneficial in persons with an acute ischemic stroke caused by a large-vessel occlusion, but its efficacy not evident for treatment of stroke caused by occlusion of medium or distal vessels.
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#NEJM #Outbreaks #Update — #H5N1, https://www.nejm.org/doi/full/10.1056/NEJMe2502267?query=TOC&cid=DM2392650_Non_Subscriber&bid=-1425531110
In this NEJM Outbreaks Update, Editor-in-Chief Eric #Rubin and Deputy Editor Lindsey Baden are joined by veterinarian and #virologist Yoshihiro #Kawaoka to discuss avian influenza and its current impact on chickens, cows, cats, and humans.
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Gotta give thumbs up to #NEJM Pain Management modules
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Gotta give thumbs up to #NEJM Pain Management modules
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Entering a New Era in #SleepApnea Treatment
TL:DR Tirzepatide resulted in 50% reduction in AHI (apnea-hypoxia index) and a lowering of blood pressure (which may reduce risk of stroke and heart attack!)
#ObstructiveSleepApnea is one of the most common respiratory disorders worldwide. Persons with obstructive sleep apnea can have loud #Snoring that is detrimental to social relationships and have breathing problems that result in recurrent nocturnal awakenings, unrefreshing sleep, and excessive daytime sleepines —effects that together can substantially impair quality of life
#obesity #osa #stroke #heart #nejm
https://www.nejm.org/doi/full/10.1056/NEJMe2407117 -
““Blessed Be the Fruit”
The Contemporary Rise of Pronatalism
“In interviews, novelist Margaret Atwood explains that her inspiration for her 1985 novel The Handmaid’s Tale arose from the U.S. political climate of the time.
Specifically, changing voter demographics and policy attitudes after the civil rights and second-wave feminist movements prompted some Reagan-era politicians to build alliances with religious traditionalists.”
#NEJM #Pronatalism #trump #jdvance #Christiannationalism #fascism
https://www.nejm.org/doi/full/10.1056/NEJMp2410208 -
Woman drips with sweat from a bite of food due to rare nerve-wiring mix-up - Enlarge (credit: Getty | MICHAEL KAPPELER)
The human body is f... - https://arstechnica.com/?p=2048913 #gustatoryhyperhidrosis #nerveregeneration #freyssyndrome #salivarygland #sweating #science #health #nerves #nejm
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A few belated points about the surprising and slightly troubling #NEJM study (https://www.nejm.org/doi/full/10.1056/NEJMoa2400645) on cognitive motor dissociation in #DisordersOfConsciousness, which I think have been underemphasized in the conversation so far:
The topline finding was that 25% of patients without observable responses to commands had fMRI or EEG evidence of awareness (physiologically meaningful activity modulation to specific commands). This is quite a bit higher than in earlier, smaller studies, many only using either fMRI or EEG.
A very surprising finding to me was in Figure S5. This shows even with the lowest possible bedside CRS-R score of 0, clinically doing nothing at the bedside, someone could have fMRI or EEG evidence of awareness. Some prior literature considers threshold scores in the range of 8 to 10, but the figure suggests that no bedside examination procedure can exclude preserved conscious awareness. This is super-humbling.
Also, 25% is really conservative, and almost certainly an underestimate. The fMRI and EEG tasks and statistical thresholds are demanding; maybe because they're from #cogsci research, they're designed to limit the likelihood of false positives. This comes at the cost of many false negatives, as seen in light blue (merely the known false negatives, there are still more undetected false negatives)--these patients follow commands at the bedside but their fMRI and EEG tests are negative. Also, given behavioral variability over time, serial assessments would have revealed more positives. While in science it's a priority to avoid false positives, arguably in the clinical setting false negative findings about consciousness are a bigger problem.
And: while this study used formal CRS-R scoring procedures from research, we know that informal clinical diagnoses of coma or the vegetative state are even less sensitive to signs of consciousness than the CRS-R. So overall in clinical settings we can presume there are many more patients falsely assessed as unconscious.
I don't do clinical work anymore with patients with disorders of consciousness, but I would take this study as a humbling reminder of how much we still don't know about consciousness and the brain. It reinforces the clinical teaching I received to treat every clinically comatose and vegetative person as if they might be covertly aware. Our bedside examination procedures and these new high-tech tests are highly specific for consciousness but also very insensitive and nonconcordant.
Philosophically and conceptually, there's important work to be done to design more sensitive and less stringent indicators of awareness, and to think more about the balance to strike between false positive and false negative findings in tests for these patients.
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Un ejercicio necesario que comienzan a hacer algunas publicaciones científicas como el #NEJM: durante siglos han perpetuado (y promovido) discriminación con presunto aval científico que nunca lo tuvo.
https://www.nejm.org/doi/full/10.1056/NEJMp2407068
A Legacy of Cruelty to Sexual and Gender Minority Groups
"This article is part of an invited series by independent historians, focused on biases and injustice that the Journal has historically helped to perpetuate..." -
Man suffers rare bee sting directly to the eyeball—it didn’t go well - Enlarge / Bees fly to their hive. (credit: Getty | Federico Gambarini) ... - https://arstechnica.com/?p=2034341 #ophthalmology #beesting #science #health #nejm #eye
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Die #Vogelgrippe #H5N1 ging in einem einmaligen Event auf Rinder über. Das ist das Ergebnis einer im #NEJM veröffentlichten virologischen Untersuchung. Knapp zuvor war es zu einem Reassortment des Virus gekommen.
➡️ Eine zufällige Mutation sorgte also offenbar für eine bessere Anpassung an Rinder (und andere Säugetiere?).
➡️ Das Virus breitete sich dann wohl von Rind zu Rind aus.Das kommt nicht überraschend, ist aber trotzdem keine gute Nachricht. Eine Anpassung des Virus an Säugetiere ist genau das, was wir nicht wollen.
Edit: Ach ja, Pasteurisierte Milch ist wohl nicht ansteckend. Das hat die Forschungsgruppe auch gezeigt.
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Update. Kudos to the Association of Health Care Journalists (#AHCJ) for its campaign against the #NEJM embargo against news outlets serving physicians. #NEJM just dropped the embargo.
https://healthjournalism.org/blog/2024/05/ahcj-advocacy-prompts-nejm-group-to-abandon-unfair-credential-policy/ -
Update. Here's some background on the candid self-examination undertaken by the New England Journal of Medicine (@nejm, #NEJM).
https://news.harvard.edu/gazette/story/2024/05/how-do-you-read-organizations-silence-over-rise-of-nazism/"In December, one of the world’s leading medical journals…began a process of self-examination, publishing articles about…its handling of a series of key historical injustices in medicine, including eugenics, slavery, oppression of Native Americans, and, in an issue published in April, the rise of Nazi Germany."
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Physiological Integration of #Taste and #Metabolism
“You don’t know what you’re missing till it’s gone” is a truism that certainly applies to taste. It took a #pandemic for taste to get attention. Severe acute respiratory syndrome #coronavirus 2 (#SARS-CoV-2) infections can cause acute loss or distortions of taste as a result of infection within taste buds1 and, in some cases, can result in long-term taste dysfunction.2,3 Since chemosensory disorders can substantially dampen a person’s enjoyment of life, this is an opportune time to appreciate recent advances in our understanding of taste.”
#covid #nejm
https://www.nejm.org/doi/full/10.1056/NEJMra2304578 -
Update. The New England Journal of Medicine (@nejm, #NEJM) continues its candid self-examination with a study of its history during the #CivilRights era.
https://www.nejm.org/doi/10.1056/NEJMp2307360"Occasionally it…took strong stands for desegregation. At the same time, it hosted a spectrum of opinions in the profession, including those of commentators who were nervous about, even hostile to, the social change swirling around them…Throughout this period…nearly all [its authors] were White."
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"The New England Journal of Medicine (#NEJM) is cutting off certain publications from advanced access to its embargoed journal articles. News outlets that report for physician readers will no longer meet criteria for embargoed access."
https://www.medpagetoday.com/special-reports/exclusives/109756PS: In other words, the readers who most need unembargoed access (for patient care and clinical application) will be denied unembargoed access.
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Teen’s vocal cords act like coin slot in worst-case ingestion accident - Enlarge (credit: Getty | Archive Photos)
Most of the time, whe... - https://arstechnica.com/?p=2015621 #foreignobject #science #health #airway #coin #nejm
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Teen’s vocal cords act like coin slot in worst-case ingestion accident - Enlarge (credit: Getty | Archive Photos)
Most of the time, whe... - https://arstechnica.com/?p=2015621 #foreignobject #science #health #airway #coin #nejm
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Teen’s vocal cords act like coin slot in worst-case ingestion accident - Enlarge (credit: Getty | Archive Photos)
Most of the time, whe... - https://arstechnica.com/?p=2015621 #foreignobject #science #health #airway #coin #nejm
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Teen’s vocal cords act like coin slot in worst-case ingestion accident - Enlarge (credit: Getty | Archive Photos)
Most of the time, whe... - https://arstechnica.com/?p=2015621 #foreignobject #science #health #airway #coin #nejm
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Teen’s vocal cords act like coin slot in worst-case ingestion accident - Enlarge (credit: Getty | Archive Photos)
Most of the time, whe... - https://arstechnica.com/?p=2015621 #foreignobject #science #health #airway #coin #nejm
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“Chemical pollution tied to fossil fuel operations poses serious risks to human health, warns a new analysis published in the New England Journal of Medicine #NEJM on Wednesday.
Citing data from dozens of studies, the report points to an alarming rise in #neurodevelopmental issues, #diabetes, chronic #respiratory disease, and certain #cancers in young people taking place amid what the paper’s author calls “explosive growth” in the petrochemical industry. “ https://mastodon.energy/@CarbonBubble/112061179143565037
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A very important result for #cancer #immunotherapy #Tecentriq in #ASPS #sarcoma. Stunning Duration of Response and PFS - hints at insights into MOA and immunity. A breakthrough for the patients whom suffer from this disease, including the 77% that are under 40 Years of Age. #NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2303383?query=featured_home
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Couple develops rare disease after beetles eating their furniture get mites - Enlarge / The common furniture beetle (Anobium punctatum). (credit: Get... - https://arstechnica.com/?p=1950055 #pyemotesventricosus #furniturebeetles #strawitchmite #dermatitis #parasites #science #beetles #disease #health #mites #toxin #nejm
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Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?
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Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?
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Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?
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Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?
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Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?
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子陵在听歌
2023-01-09 https://weibo.com/1251560221/MnseR2Rx3#新型冠状病毒 SARS-CoV-2是一个正链#RNA病毒，不是#逆转录病毒，它没有#逆转录酶。#阿兹夫定 是一个活性不强的#HIV 逆转录酶#抑制剂，对SARS-CoV-2没有#抗病毒活性。而#Paxlovid 中的有效成分#Nirmatrelvir 是用最先进的#药化设计 方法根据SARS-CoV-2蛋白酶Mpro（3CL）#构象结构 修饰出来的（https://weibo.com/1251560221/LbrLu7UAZ ）。
阿兹夫定没有任何发表在#同行审阅 杂志上的有效性#临床试验 结果（https://weibo.com/7597822550/Mn9EBCRlo ）。Paxlovid的有效性#3期临床试验 结果发表在全世界最权威的医学杂志#NEJM 上，是目前唯一能降低SARS-CoV-2#病毒载量 的#小分子抗病毒药（https://weibo.com/1251560221/M4Ut7y5TQ ）；在其上市后多个独立的第三方机构在权威#医学杂志 上发表了其真实世界有效性数据。
其实每个国家都有相关政策保护自己的#民族工业，对我而言，这并不陌生。如果去翻我之前的微博，我在微博上追踪了#抗病毒药 十几年，见证了很多重磅抗病毒药在#CDE 和#医保局 来来回回洽谈多年，比如#DTG 和#必妥维。HIV药物可以用几年来谈，但是在#重大传染病 #公共卫生 危机中，还用惯性方法去处理危机，可见一些机构的优先级是什么。当然，没有医学#科学训练、也非#医药卫生行业 从业者的人可能为此叫好，但接受过相关训练的从业者则无话可说。
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分析#阿兹夫定 的#临床试验数据：一个打死不冤的伪#新冠特效药
Y博的科普园 一个生物狗的科普小园 2023-01-07 https://mp.weixin.qq.com/s/IrIfACWflj6ZwGe6CqHERw
申明：仅代表个人观点，不代表任何组织与单位
这几天有报道说阿兹夫定的#三期临床试验 公布，显著缩短核酸转阴时间。这个药之前写过很多，#有效性极为可疑，安全性上的#遗传、#生殖毒性 问题更无法解决（详见二条）。
但很多人还在问，所以就去看了所谓显示有效的#巴西 三期临床试验，其实根本谈不上显示有效性，部分内容也与之前相关药企IPO文件里提到的其它#临床试验 结果冲突。此药能上架就已荒唐，如果你有（不）幸拿到阿兹夫定，扔了算了。 -
@thelizarmy patient-investigator extraordinaire publishes her #POV on awake #craniotomy for her #BrainTumor, provider-#patient #communication, #SharedDecisionMaking in #NEJM — check it out!
NEJM (paywall): https://www.nejm.org/doi/full/10.1056/NEJMp2210418
Birdsite: https://twitter.com/thelizarmy/status/1599873193439039488
#PatientEngagement #PatientEmpowerment #MedEd #MedMastodon #mediverse #PatientVoice
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I've used #OpenAPS every day for the past 8 years. It works! Thousands of people have used it and similar open source AID systems over the years.
Recently, the #OpenAPS algorithm I designed - by teaching someone how I manage #diabetes manually and realizing we could 'teach' a computer the same rules - was also proven safe and effective in a randomized control trial (RCT) in both children and adults.
Results from the RCT were published in #NEJM: https://bit.ly/3AWqlqf
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Mehr was für die Medizin-Bubble:
In diesem heute erschienenen #NEJM-Paper wurde bei Menschen mit fortgeschrittener Niereninsuffizienz (GFR <30) geschaut, ob das Absetzen von ACE-Hemmern bzw AT1-Blockern die weitere Verschlechterung verlangsamt.
Tat es nicht. Und auch Adverse Events waren mit und ohne RAAS-Blockade praktisch gleich.
Ich würde das Ergebnis umgekehrt interpretieren: Es gibt keinen Grund, RAAS-Blocker bei schlechter werdender chron. Niereninsuffizienz abzusetzen. Auch bei GFR 20 darf man die Herzinsuffizienz behandeln.