Live and recent posts from across the Fediverse tagged #clonalhematopoiesis, aggregated by home.social.
Postdoctoral research fellow
University of Chicago
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744
Postdoctoral research fellow
University of Chicago
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554
Postdoctoral research fellow
University of Chicago
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=2405
Genetic Study Suggests Ways to Catch Blood Cancer Earlier
Newswise — As we age, our cells replicate, and the DNA in these cells can acquire mistakes —…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #AllJournalNews #Biotech #blood #cancer #clonalhematopoiesis;BloodCancer;CancerRisk #EthicsandResearchMethods #Healthcare #Nature(journal) #Newswise #Science #Stemcells #WashingtonUniversityinSt.Louis
https://www.newsbeep.com/us/102355/
Genetic Study Suggests Ways to Catch Blood Cancer Earlier
Newswise — As we age, our cells replicate, and the DNA in these cells can acquire mistakes —…
#NewsBeep #News #Genetics #AllJournalNews #AU #Australia #Biotech #Blood #Cancer #clonalhematopoiesis;BloodCancer;CancerRisk #EthicsandResearchMethods #Healthcare #naturejournal #Newswise #Science #StemCells #WashingtonUniversityinSt.Louis
https://www.newsbeep.com/au/87474/
https://www.europesays.com/uk/364638/ Genetic Study Suggests Ways to Catch Blood Cancer Earlier #AllJournalNews #Biotech #Blood #Cancer #ClonalHematopoiesis;BloodCancer;CancerRisk #EthicsAndResearchMethods #Genetics #Healthcare #Nature(journal) #Newswise #Science #StemCells #UK #UnitedKingdom #WashingtonUniversityInSt.Louis
Postdoctoral research fellow
University of Chicago
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=1005
Postdoctoral research fellow
University of Chicago
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=795
Join us Thurs, April 27 at noon CT/1 pm ET as Dr. Fernando Camargo of Boston Children’s Hospital presents “Lineage Histories and Function in the Hematopoietic System.” Camargo’s work is aimed at dissecting the lineage trees of developing tissues and how understanding where cells come from might provide insights into the developmental origins of cancer. Register. https://bit.ly/SOCC23-MAS #SOCC23 #CancerResearch #ClonalHematopoiesis
Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease
While #ClonalHematopoiesis mutations in the blood are known to contribute to #IschemicCardiovascularDisease, most studies have focused on the impact on the heart. A new study looks at the prevalence of #CHIP mutations in young #stroke patients and finds high enrichment (>3 times greater than general population studies). Moreover, there was a high prevalence of CHIP even among youngest patients with stroke (age < 40 years old). Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041416 #medicine #science #genomics #neurology
Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics
Concise & timely review from my colleague Sarah Reed out in #AACR #ClinicalCancerResearch about #ClonalHematopoiesis in #SolidTumors. See the nice summary figure below and find the full text here: https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2598/711363/CHIP-Happens-Clonal-hematopoiesis-of-indeterminate #medicine #science #hematology #oncology #cancer #immunology
Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology
Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine
One way that mutated immune cells might lead to an observed increase in #cardiovascular disease is through secretion of inflammatory #cytokines. In this recent abstract, the authors analyzed levels of 1,300 serum proteins for their association with #ClonalHematopoiesis mutations, finding that #TET2 mutations had several strong associations. Interesting to me that different CH mutations have different cytokine profiles, despite converging on increased #CVD risk: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.15719 #omics
New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis
New research in #Rheumatology shows that #ClonalHematopoiesis is much more common in patients with #Lupus (#SLE) than the overall population. However, the prevalence didn't appear to be associated with use of immunosuppressive therapies: https://academic.oup.com/rheumatology/article-abstract/61/11/4355/6530303 #medicine #science
Nice review on #ClonalHematopoiesis and #heartdisease. Discusses how acquired mutations affecting immune cells can potentiate coronary artery disease through multiple inflammatory pathways: https://www.nature.com/articles/s44161-022-00154-1 #genomics #hematology #cardiology #medicine #science
Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq
Here's a new American Heart Association abstract from some of my colleagues, who used #scRNAseq to look at transcriptional changes in mutated blood cells (which they identified as mutant via tagging mitochondrial transcript mutations). They found myeloid bias in all the #ClonalHematopoiesis samples but also distinct inflammatory gene expression profiles depending on the mutation: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.14781 #Genomics #Hematology
Seeing a lot of awesome #neuroscience people on here - while I mostly focus on #hematology, here's a thought-provoking manuscript that has some crossover. In it, the authors find that individuals with somatic mutation in the #blood (AKA #ClonalHematopoiesis or #CHIP) are less likely to have #Alzheimers disease: https://www.medrxiv.org/content/10.1101/2021.12.10.21267552v1.full
My initial #introduction was a bit sparse, so here are more areas where I engage: #health #healthcare #medicine #physicianscientist #MDPhD #DoubleDocs #science #research #academic #biology #humandisease #aging #hematology #haematology #hematopoiesis #blood #stemcells #germline #somaticgenetics #mosaicism #mutation #SNV #mCA #genetics #genomics #populationgenetics #AML #MDS #MPN #myeloid #ClonalHematopoiesis #CHIP #inflammation #bonemarrow #HSC #biobank #molecularbiology #geneediting #CRISPR #NGS