#clonalhematopoiesis — Public Fediverse posts

Postdoctoral research fellow
University of Chicago

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/

#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744

Postdoctoral research fellow
University of Chicago

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/

#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554

Join us Thurs, April 27 at noon CT/1 pm ET as Dr. Fernando Camargo of Boston Children’s Hospital presents “Lineage Histories and Function in the Hematopoietic System.” Camargo’s work is aimed at dissecting the lineage trees of developing tissues and how understanding where cells come from might provide insights into the developmental origins of cancer. Register. https://bit.ly/SOCC23-MAS #SOCC23 #CancerResearch #ClonalHematopoiesis

Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease

Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease

Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease

Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease

Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease

Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics

Concise & timely review from my colleague Sarah Reed out in #AACR #ClinicalCancerResearch about #ClonalHematopoiesis in #SolidTumors. See the nice summary figure below and find the full text here: https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2598/711363/CHIP-Happens-Clonal-hematopoiesis-of-indeterminate #medicine #science #hematology #oncology #cancer #immunology

Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology

New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis

Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq

My initial #introduction was a bit sparse, so here are more areas where I engage: #health #healthcare #medicine #physicianscientist #MDPhD #DoubleDocs #science #research #academic #biology #humandisease #aging #hematology #haematology #hematopoiesis #blood #stemcells #germline #somaticgenetics #mosaicism #mutation #SNV #mCA #genetics #genomics #populationgenetics #AML #MDS #MPN #myeloid #ClonalHematopoiesis #CHIP #inflammation #bonemarrow #HSC #biobank #molecularbiology #geneediting #CRISPR #NGS