#clonalhematopoiesis — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #clonalhematopoiesis, aggregated by home.social.
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Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=5744 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=4554 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=2405 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=2405 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=2405 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=2405 -
Genetic Study Suggests Ways to Catch Blood Cancer Earlier
Newswise — As we age, our cells replicate, and the DNA in these cells can acquire mistakes —…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #AllJournalNews #Biotech #blood #cancer #clonalhematopoiesis;BloodCancer;CancerRisk #EthicsandResearchMethods #Healthcare #Nature(journal) #Newswise #Science #Stemcells #WashingtonUniversityinSt.Louis
https://www.newsbeep.com/us/102355/ -
Genetic Study Suggests Ways to Catch Blood Cancer Earlier
Newswise — As we age, our cells replicate, and the DNA in these cells can acquire mistakes —…
#NewsBeep #News #Genetics #AllJournalNews #AU #Australia #Biotech #Blood #Cancer #clonalhematopoiesis;BloodCancer;CancerRisk #EthicsandResearchMethods #Healthcare #naturejournal #Newswise #Science #StemCells #WashingtonUniversityinSt.Louis
https://www.newsbeep.com/au/87474/ -
https://www.europesays.com/uk/364638/ Genetic Study Suggests Ways to Catch Blood Cancer Earlier #AllJournalNews #Biotech #Blood #Cancer #ClonalHematopoiesis;BloodCancer;CancerRisk #EthicsAndResearchMethods #Genetics #Healthcare #Nature(journal) #Newswise #Science #StemCells #UK #UnitedKingdom #WashingtonUniversityInSt.Louis
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Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=1005 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=1005 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=1005 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=1005 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=795 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=795 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=795 -
Postdoctoral research fellow
University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/
#ClonalHematopoiesis #drugdiscovery #leukemia #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-chicago-27778-postdoctoral-research-fellow/?fsp_sid=795 -
Join us Thurs, April 27 at noon CT/1 pm ET as Dr. Fernando Camargo of Boston Children’s Hospital presents “Lineage Histories and Function in the Hematopoietic System.” Camargo’s work is aimed at dissecting the lineage trees of developing tissues and how understanding where cells come from might provide insights into the developmental origins of cancer. Register. https://bit.ly/SOCC23-MAS #SOCC23 #CancerResearch #ClonalHematopoiesis
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Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease
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Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease
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Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease
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Interesting new paper in #Nature finds that #ClonalHematopoiesis mutations in the blood can contribute to #ChronicLiverDisease. The authors use a combination of human cohort data and mouse models to show that these mutations lead to more #inflammatory changes in the #liver. https://www.nature.com/articles/s41586-023-05857-4 #science #medicine #genomics #hematology #hepatology #LiverDisease
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While #ClonalHematopoiesis mutations in the blood are known to contribute to #IschemicCardiovascularDisease, most studies have focused on the impact on the heart. A new study looks at the prevalence of #CHIP mutations in young #stroke patients and finds high enrichment (>3 times greater than general population studies). Moreover, there was a high prevalence of CHIP even among youngest patients with stroke (age < 40 years old). Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041416 #medicine #science #genomics #neurology
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While #ClonalHematopoiesis mutations in the blood are known to contribute to #IschemicCardiovascularDisease, most studies have focused on the impact on the heart. A new study looks at the prevalence of #CHIP mutations in young #stroke patients and finds high enrichment (>3 times greater than general population studies). Moreover, there was a high prevalence of CHIP even among youngest patients with stroke (age < 40 years old). Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041416 #medicine #science #genomics #neurology
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While #ClonalHematopoiesis mutations in the blood are known to contribute to #IschemicCardiovascularDisease, most studies have focused on the impact on the heart. A new study looks at the prevalence of #CHIP mutations in young #stroke patients and finds high enrichment (>3 times greater than general population studies). Moreover, there was a high prevalence of CHIP even among youngest patients with stroke (age < 40 years old). Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041416 #medicine #science #genomics #neurology
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While #ClonalHematopoiesis mutations in the blood are known to contribute to #IschemicCardiovascularDisease, most studies have focused on the impact on the heart. A new study looks at the prevalence of #CHIP mutations in young #stroke patients and finds high enrichment (>3 times greater than general population studies). Moreover, there was a high prevalence of CHIP even among youngest patients with stroke (age < 40 years old). Link: https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041416 #medicine #science #genomics #neurology
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Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics
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Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics
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Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics
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Wanted to share this great work on curating #ClonalHematopoiesis (#CHIP) in biobanks just published in #Blood. This work, led by Dr. Caitlyn Vlasschaert, used known CHIP associations with #aging, #germline variants, and #HealthOutcomes to carefully define variant calling criteria in All of Us and UK Biobank studies (N > 500K). The call sets are in the process of being returned to the biobanks so that they may be used by researchers anywhere! Link: https://doi.org/10.1182/blood.2022018825 #medicine #genomics
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Concise & timely review from my colleague Sarah Reed out in #AACR #ClinicalCancerResearch about #ClonalHematopoiesis in #SolidTumors. See the nice summary figure below and find the full text here: https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2598/711363/CHIP-Happens-Clonal-hematopoiesis-of-indeterminate #medicine #science #hematology #oncology #cancer #immunology
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Concise & timely review from my colleague Sarah Reed out in #AACR #ClinicalCancerResearch about #ClonalHematopoiesis in #SolidTumors. See the nice summary figure below and find the full text here: https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-2598/711363/CHIP-Happens-Clonal-hematopoiesis-of-indeterminate #medicine #science #hematology #oncology #cancer #immunology
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Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology
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Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology
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Interesting study in #ScientificReports that did #transcriptome profiling of surgically-removed calcified aortic valves from patients with/without #ClonalHematopoiesis. The authors found broad changes to immune cell infiltrates but also to #antibody profiles that correlated with survival. This last point is cool because CH's impact on #myeloid biology is often discussed, but it can obviously have important effects on #lymphoid cells, too: https://www.nature.com/articles/s41598-022-24130-8 #science #medicine #cardiology
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Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine
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Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine
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Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine
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Nice review on the #biology of #ClonalHematopoiesis that covers both acquired point mutations (i.e., CHIP) and large mosaic chromosomal alterations (mCAs). I especially like this figure summarizing known risk factors for each. Full text here: https://www.sciencedirect.com/science/article/abs/pii/S1931524422002511 #hematology #genetics #genomics #science #medicine
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One way that mutated immune cells might lead to an observed increase in #cardiovascular disease is through secretion of inflammatory #cytokines. In this recent abstract, the authors analyzed levels of 1,300 serum proteins for their association with #ClonalHematopoiesis mutations, finding that #TET2 mutations had several strong associations. Interesting to me that different CH mutations have different cytokine profiles, despite converging on increased #CVD risk: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.15719 #omics
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One way that mutated immune cells might lead to an observed increase in #cardiovascular disease is through secretion of inflammatory #cytokines. In this recent abstract, the authors analyzed levels of 1,300 serum proteins for their association with #ClonalHematopoiesis mutations, finding that #TET2 mutations had several strong associations. Interesting to me that different CH mutations have different cytokine profiles, despite converging on increased #CVD risk: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.15719 #omics
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New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis
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New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis
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New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis
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New research in #Rheumatology shows that #ClonalHematopoiesis is much more common in patients with #Lupus (#SLE) than the overall population. However, the prevalence didn't appear to be associated with use of immunosuppressive therapies: https://academic.oup.com/rheumatology/article-abstract/61/11/4355/6530303 #medicine #science
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New research in #Rheumatology shows that #ClonalHematopoiesis is much more common in patients with #Lupus (#SLE) than the overall population. However, the prevalence didn't appear to be associated with use of immunosuppressive therapies: https://academic.oup.com/rheumatology/article-abstract/61/11/4355/6530303 #medicine #science
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New research in #Rheumatology shows that #ClonalHematopoiesis is much more common in patients with #Lupus (#SLE) than the overall population. However, the incidence didn't appear to be associated with use of immunosuppressive therapies: https://academic.oup.com/rheumatology/article-abstract/61/11/4355/6530303 #medicine #science
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Nice review on #ClonalHematopoiesis and #heartdisease. Discusses how acquired mutations affecting immune cells can potentiate coronary artery disease through multiple inflammatory pathways: https://www.nature.com/articles/s44161-022-00154-1 #genomics #hematology #cardiology #medicine #science
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Nice review on #ClonalHematopoiesis and #heartdisease. Discusses how acquired mutations affecting immune cells can potentiate coronary artery disease through multiple inflammatory pathways: https://www.nature.com/articles/s44161-022-00154-1 #genomics #hematology #cardiology #medicine #science
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Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq
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Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq
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Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq
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Here's a new American Heart Association abstract from some of my colleagues, who used #scRNAseq to look at transcriptional changes in mutated blood cells (which they identified as mutant via tagging mitochondrial transcript mutations). They found myeloid bias in all the #ClonalHematopoiesis samples but also distinct inflammatory gene expression profiles depending on the mutation: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.14781 #Genomics #Hematology
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Here's a new American Heart Association abstract from some of my colleagues, who used #scRNAseq to look at transcriptional changes in mutated blood cells (which they identified as mutant via tagging mitochondrial transcript mutations). They found myeloid bias in all the #ClonalHematopoiesis samples but also distinct inflammatory gene expression profiles depending on the mutation: https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.14781 #Genomics #Hematology