#wrn — Public Fediverse posts

WRN helicase (PDB: 2QZ2) — Walker A/B and Sensor 1 motifs coordinate ADP–Mg²⁺ in the post-hydrolysis state. C-terminal tail (L514) couples helicase and exonuclease activities.

WRN loss → Werner syndrome + simultaneous acceleration of telomere attrition, epigenetic dysregulation, and stem cell exhaustion. A structural window into multi-hallmark aging.

#WRN #WernerSyndrome #StructuralBiology #LongevityBiology #DNARepair #Biogerontology #AgingHallmarks

#Trans #women should be #counted as #women in #Senedd #elections.

#Welsh #Labour and #PlaidCymru want to make #political #parties draw up equal #lists of #men and #women #candidates.

#Draft #legislation, leaked by the #Transphobic Hategroup #WRN, suggests the #lists of #women could include #candidates who are planning #GenderReassignment as required by #UK #Equalities #Law.

#Women #Transgender #LGBTQ #LGBTQIA #UK #TERFS #Hate #Bigotry #Transphobia #TERFIsland
https://www.bbc.com/news/uk-wales-politics-67261883

We welcome our new Weather Ready National Ambassador, Lorain County EMA. #ohwx #WRN

What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?

Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage

https://www.embopress.org/doi/10.15252/embj.2022111998

What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?

Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage

https://www.embopress.org/doi/10.15252/embj.2022111998

What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?

Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage

https://www.embopress.org/doi/10.15252/embj.2022111998

What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?

Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage

https://www.embopress.org/doi/10.15252/embj.2022111998

Grateful today for a great meeting with beloved colleagues, the #WomensRabbinicNetwork or #WRN. I told them about #BabkaSocial and I hope some will take me up on my offer of help getting on Mastodon.