#aginghallmarks — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #aginghallmarks, aggregated by home.social.
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WRN helicase (PDB: 2QZ2) — Walker A/B and Sensor 1 motifs coordinate ADP–Mg²⁺ in the post-hydrolysis state. C-terminal tail (L514) couples helicase and exonuclease activities.
WRN loss → Werner syndrome + simultaneous acceleration of telomere attrition, epigenetic dysregulation, and stem cell exhaustion. A structural window into multi-hallmark aging.
#WRN #WernerSyndrome #StructuralBiology #LongevityBiology #DNARepair #Biogerontology #AgingHallmarks