#helicase — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #helicase, aggregated by home.social.
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@mzdravkov we've observed that in all runs, usually a few % of reads, sometimes over 10%. When you plot raw signals, you'll see strange stretches similar to homopolymer... we haven't observe anything like this in rna002, only in rna004.
my working hypothesis it that's because of helicase #stalling specific to new #RNA #helicase variant used in #rna004
@nanopore -
@mzdravkov we've observed that in all runs, usually a few % of reads, sometimes over 10%. When you plot raw signals, you'll see strange stretches similar to homopolymer... we haven't observe anything like this in rna002, only in rna004.
my working hypothesis it that's because of helicase #stalling specific to new #RNA #helicase variant used in #rna004
@nanopore -
Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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CMG #helicase disassembly is essential and driven by two pathways in budding yeast
Karim Labib and colleagues show that Pif1-family helicases mediate an ancestral pathway for ‘old’ #replisome disassembly during the subsequent S-phase
https://www.embopress.org/doi/full/10.1038/s44318-024-00161-x -
CMG #helicase disassembly is essential and driven by two pathways in budding yeast
Karim Labib and colleagues show that Pif1-family helicases mediate an ancestral pathway for ‘old’ #replisome disassembly during the subsequent S-phase
https://www.embopress.org/doi/full/10.1038/s44318-024-00161-x -
#Microcephaly protein #DONSON is a novel factor needed for CMG #helicase assembly during vertebrate DNA #replication initiation
Yoshitami Hashimoto and colleagues
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#Microcephaly protein #DONSON is a novel factor needed for CMG #helicase assembly during vertebrate DNA #replication initiation
Yoshitami Hashimoto and colleagues
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Basic fundamental research on how DNA functions and how our cells work on a molecular level is critical to broader insights and innovations.
Delft University of Technology scientists have more precisely found how the helicase CMG unwinds DNA during replication and its full functionality in doing so with a new mechanism.
#Science #DNA #Replication #Helicase #CMG #Biology #Biochemistry #Molecular #SciComm
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Basic fundamental research on how DNA functions and how our cells work on a molecular level is critical to broader insights and innovations.
Delft University of Technology scientists have more precisely found how the helicase CMG unwinds DNA during replication and its full functionality in doing so with a new mechanism.
#Science #DNA #Replication #Helicase #CMG #Biology #Biochemistry #Molecular #SciComm
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage