#helicase — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #helicase, aggregated by home.social.
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@mzdravkov we've observed that in all runs, usually a few % of reads, sometimes over 10%. When you plot raw signals, you'll see strange stretches similar to homopolymer... we haven't observe anything like this in rna002, only in rna004.
my working hypothesis it that's because of helicase #stalling specific to new #RNA #helicase variant used in #rna004
@nanopore -
Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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#Microcephaly protein #DONSON is a novel factor needed for CMG #helicase assembly during vertebrate DNA #replication initiation
Yoshitami Hashimoto and colleagues
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage