#syntheticlethality — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #syntheticlethality, aggregated by home.social.
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Great news that the group Sebastian Pomplun of our LED3 hub and the Leiden Academic Centre for Drug Research has been awarded a 1.18 Mio € grant by KWF Kankerbestrijding to explore EXO1 as a synthetically lethal target in BRCA1-deficient tumors. The research will be performed in collaboration with the group of Sylvie Noordermeer at the Leiden University Medical Center.
Congratulations to all involved!
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What is the #molecular basis of #syntheticlethality between loss of Werner #helicase #WRN and #mismatchrepair #MMR proteins particularly in #cancer cells with #microsatellite instability?
Using #biochemcial assays, Petr Cejka and colleages, Bellinzona LRB, show how they synergistically and independently unfold #cruciform #DNA structures, with WRN preventing their cleavage by #SLX1-#SLX4 structure-specific #endonuclease and DNA breakage