#nmd — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #nmd, aggregated by home.social.
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Nonsense-mediated mRNA decay (#NMD) is an RNA degradation pathway that is conserved in eukaryotes. Its study led to a better understanding of other major cellular processes, such as DNA transcription or mRNA translation. In a recent review, we highlight the impressive conservation of the molecular mechanisms involved in this pathway, from yeast to mammalian cells:
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https://www.europesays.com/afrique/70667/ une nouvelle feuille de route 2026-2032 pour renforcer la gouvernance des finances publiques #FinancesPubliques #gouvernance #Maroc #NMD #réforme
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Thank you #biorxiv staff for processing the pre-prints so quickly and nicely. Our latest manuscript addresses a rather specialized, albeit important, question in mRNA degradation in yeast. To what extent the Lsm1-7/Pat1 complex is involved in the degradation of mRNA by decapping activation ? By using a degron strain allowing rapid depletion of Lsm1, we find a slight impact of the complex on decapping, including changes in #NMD substrate levels.
https://www.biorxiv.org/content/10.64898/2025.12.17.694855v1
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@bsky.app.profile.cmcireland.bsky.social I enjoyed the Cór Linn & Cór na nÓg concert on Sunday with Mary Amond O'Brien, Ciarán Kelly, and the Leinster String quartet. Lovely pieces by Seán Doherty, the late Sue Furlong, Marian Ingoldsby, and Ciarán Kelly with Carl Corcoran. What a pleasure to see well-trained young singers really enjoying their performance!
#contemporarymusic #choral #dublin #NMD #NCH -
I'm looking forward to today's New Music Dublin concert in the NCH 12:30. Cór Linn and Cór na nÓg.
I have a personal connection to three of the composers.Seán Doherty All the Things Magicians Do (text by C.S. Lewis)
Sue Furlong Peace Songs from County Wexford
Marian Ingoldsby Mol an Óige (World Premiere) (texts: Irish proverb, Emily Dickinson,)
Sue Furlong Mo Ghile Mear
Ciarán Kelly / Carl Corcoran A Child of the Universe (World Premiere) (text by Max Ehrmann) -
In a recent pre-print for a project led by Gwenael Badis and with the first author Toni Gouhier, we show that #Upf1, the core helicase of nonsense-mediated mRNA decay (#NMD), can selectively bind short poly(A) RNA and help their degradation. This is a new function for NMD!
Images show the levels of short poly(A) tailed RNA in the Upf1-associated RNA fraction and the impact of the absence of Upf1 on the levels of this particular population (for a reporter).
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Nonsense mediated mRNA decay (#NMD) is frequently a target of viral proteins since an active NMD can limit viral replication. As shown by the lovely work of Fiorini and colleagues, the N protein of #SARS-CoV-2 physically and functionally interact with #Upf1 and #Upf2, two core NMD factors. These results complement previously published studies, such as the one from the Makino group, 2018, on the murine hepatitis virus, a related coronavirus.
https://pubmed.ncbi.nlm.nih.gov/39831305/
https://pubmed.ncbi.nlm.nih.gov/30297408/ -
🎉 It's New Monitor Day! 🎉
We just unboxed the MSI MPG 321URX QD-OLED—32" of ultra-sharp, buttery-smooth 4K goodness.
Time to put this beast to the test—let’s see what it can do! 🔥
Check out our new video now 👉 https://youtu.be/TGVZsbJA2dg?si=fnduxwmAn0zrzV2O
#NewMonitorDay #NMD #AstroAtomica #YouTuber #YouTube
#4k #QDOLED #OLED #Gaming #Editing #VideoEditing #unboxing #MSI #321URX #MPG321URX -
Ócio leva ao vício: #Óciocast nº 63, #DCCcomMarcelão 2024-05-04 Ascensão do Caos nº 1 + Informe aos assinantes do Telegram + #resenha #Xmen97 + Resenha de #DeadpooleWolverine + #SDN 2024-11-07, Secretaria de (não)Conservação + #NMD nº 16, #ASoC #podifusão #JP #jogodecartas https://ociolevaaovicio.blogspot.com/2024/12/ociocast-n-63-dcc-com-marcelao-2024-05.html
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New #paper! Structural and functional data from the Marc Graille lab, together with in vitro experiments from the Le Hir lab and our #yeast experiments, identified specific interactions between Upf1, the core #NMD RNA helicase and Nmd4, the yeast equivalent of SMG6 (the NMD #endonuclease in many organisms). Another surprising result showing how conserved NMD mechanisms are!
https://pubmed.ncbi.nlm.nih.gov/39331656/
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002821 -
Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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Does the mechanism of #NonsenseMediatedDecay (#NMD) differ between yeast & animals? @GrailleLab &co use the structure of Upf1 RNA #helicase in complex with Nmd4 to show that metazoan SMG6 NMD factor binds to Upf1 using a conserved binding mode #PLOSBiology https://plos.io/4eEZgtL
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An exhaustive analysis of #transcript isoforms in human cells suggests that 15% of the transcripts produced for protein-coding genes are unproductive and get degraded through #NMD. This is the most extensive analysis of the importance of NMD in clearing useless badly #spliced transcripts. (1/2)
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An exhaustive analysis of #transcript isoforms in human cells suggests that 15% of the transcripts produced for protein-coding genes are unproductive and get degraded through #NMD. This is the most extensive analysis of the importance of NMD in clearing useless badly #spliced transcripts. (1/2)
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An exhaustive analysis of #transcript isoforms in human cells suggests that 15% of the transcripts produced for protein-coding genes are unproductive and get degraded through #NMD. This is the most extensive analysis of the importance of NMD in clearing useless badly #spliced transcripts. (1/2)
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An exhaustive analysis of #transcript isoforms in human cells suggests that 15% of the transcripts produced for protein-coding genes are unproductive and get degraded through #NMD. This is the most extensive analysis of the importance of NMD in clearing useless badly #spliced transcripts. (1/2)
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New Monitor Day for Alli !!!
It's the MPG-321URX QD-OLED from MSI.
Now we both have the same monitor.
-- Should we review it?
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New YouTube video from Victoria Monét:
✨ “SOS (Sex On Sight)”ft. @usher 🆘 Listen now & watch me share all details on #NMD @AppleMusic
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New YouTube video from Nelly Furtado:
✨ LOVE YOU Zane Lowe 💯 Listen to “Love Bites” and full interview on @AppleMusic 💄🫦 #NMD
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Very happy to see the story led by Marc Graille and to which we collaborated published as a pre-print. It shows that specific protein-protein interaction motifs involved in nonsense-mediated #mRNA decay (#NMD) have been preserved over billions of years of evolution.
Yeast Nmd4 is probably the most reduced form equivalent of mammalian SMG-6 and enhances the binding of #Upf1 to RNA.
https://www.biorxiv.org/content/10.1101/2024.02.27.582253v1.full
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Watching worm #RNA: @mango_s_lab adapt the MS2-MCP system to visualize endogenous #mRNAs in #Celegans. Inactivating #NMD & expressing low levels of cytoplasmic MCP allows live imaging of functional transcripts in #nematodes @biozentrum #PLOSBiology https://plos.io/3wBaMpA
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East London based rapper / producer Parallax releases studio booth video for Checkmate. NMD on the buttons for this reality flow coming straight from Parallax's heart.
#Checkmate #ForestDLG #KMJ45 #NMD #parallax #parallaxofficial
https://www.britishhiphop.co.uk/downloads/video/parallax-checkmate-video.html
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Discussie over MPG / MKI
Er is een fundamentele discussie over aannames bij MPG/MKI berekeningen nodig: De Nationale Milieudatabase (NMD) meldde afgelopen week dat de warmtepomp zó slecht scoort qua milieuimpact, dat nieuwe gebouwen amper nog zouden voldoen aan de MPG eisen. (link)
De oorzaak
http://www.passievoorsystemen.nl/2023/03/aannames-bij-mpg-mki-berekeningen/
#Duurzaamheid #Economie #Techniek #berekenen #innovatie #MKI #model #modellen #MPG #Nationalemilieudatabase #NMD
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Discussie over MPG / MKI
Er is een fundamentele discussie over aannames bij MPG/MKI berekeningen nodig: De Nationale Milieudatabase (NMD) meldde afgelopen week dat de warmtepomp zó slecht scoort qua milieuimpact, dat nieuwe gebouwen amper nog zouden voldoen aan de MPG eisen. (link)
De oorzaak
http://www.passievoorsystemen.nl/2023/03/aannames-bij-mpg-mki-berekeningen/
#Duurzaamheid #Economie #Techniek #berekenen #innovatie #MKI #model #modellen #MPG #Nationalemilieudatabase #NMD
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Discussie over MPG / MKI
Er is een fundamentele discussie over aannames bij MPG/MKI berekeningen nodig: De Nationale Milieudatabase (NMD) meldde afgelopen week dat de warmtepomp zó slecht scoort qua milieuimpact, dat nieuwe gebouwen amper nog zouden voldoen aan de MPG eisen. (link)
De oorzaak
http://www.passievoorsystemen.nl/2023/03/aannames-bij-mpg-mki-berekeningen/
#Duurzaamheid #Economie #Techniek #berekenen #innovatie #MKI #model #modellen #MPG #Nationalemilieudatabase #NMD
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Discussie over MPG / MKI
Er is een fundamentele discussie over aannames bij MPG/MKI berekeningen nodig: De Nationale Milieudatabase (NMD) meldde afgelopen week dat de warmtepomp zó slecht scoort qua milieuimpact, dat nieuwe gebouwen amper nog zouden voldoen aan de MPG eisen. (link)
De oorzaak
http://www.passievoorsystemen.nl/2023/03/aannames-bij-mpg-mki-berekeningen/
#Duurzaamheid #Economie #Techniek #berekenen #innovatie #MKI #model #modellen #MPG #Nationalemilieudatabase #NMD
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This just published from Jeff Chao's lab
@MolecularCell"Single-molecule imaging reveals translation-dependent destabilization of mRNAs"
#mRNA #mRNADegradation #miRNA #translation #imaging #SingleMolecule #NMD
https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00033-3
When the bioRxiv came out (along with 2 others on similar topic), I wrote about it in my blog:
There are several additions in the print version, e.g. adding miR-21. but its just 1st impression. Have to read it.
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Pre-mRNA splicing patterns cannot be accurately defined from total RNA data, unless degradation pathways are inactive. An example, using NMD inactivation (wondering to what extent nuclear degradation could be also involved ?):
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#nmd is a collection of #publicdomain #singleheader libraries.
nmd is a set of #C libraries, including a (dis)assembler for #x86, a 2D graphics library, a sockets library, and a WIP C preprocessor. All nmd utilities are made in #C89 with cross platform support (including cross-framework), allowing for nmd libraries to be used on practically any platform, including #embedded.
Website 🔗️: https://github.com/Nomade040/nmd
