#rnai — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #rnai, aggregated by home.social.
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Custom RNA Oligos Market in Italy | Report – IndexBox
Italy Custom RNA Oligos Marke…
#Italy #Europe #Europa #EU #2'-O-methyl) #Antisenseoligonucleotideresearch #biopharmamarketreport #CustomRNAoligos #Diagnosticprobedevelopment #forecast #Geneediting(CRISPRgRNA) #Genesilencing(siRNA #marketanalysis #Massspectrometry(MS)forQC #Modificationchemistry(2'-fluoro #Reverse-phaseandion-exchangeHPLCpurification #RNAi) #Solid-phasephosphoramiditesynthesis
https://www.europesays.com/italy/14486/ -
La vida como científico es sacrificada pero también gratificante. Y a veces gratamente inesperada. Hoy la empresa @alnylam experta en terapias #RNAi para #enfermedadesraras inaugura una sala de seminarios en su sede en Madrid a la que ha decidido poner mi nombre. Un inmenso honor
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Traditionally, vaccines contain either a dead or modified, live version of a virus. The body’s immune system recognizes a protein in the virus and mounts an immune response.
This response produces T-cells that attack the virus and stop it from spreading.
It also produces “memory” B-cells that train your immune system to protect you from future attacks.
The new vaccine also uses a live, modified version of a virus.
However, it does not rely on the vaccinated body having this traditional immune response or immune active proteins
— which is the reason it can be used by babies whose immune systems are underdeveloped, or people suffering from a disease that overtaxes their immune system.Instead, this relies on small, silencing RNA molecules.
“A host — a person, a mouse, anyone infected— will produce small "interfering RNAs" as an immune response to viral infection.
These #RNAi then knock down the virus,” said Shouwei Ding, distinguished professor of microbiology at UCR, and lead paper author.
The reason viruses successfully cause disease is because they produce proteins that block a host’s RNAi response.
👉“If we make a mutant virus that cannot produce the protein to suppress our RNAi, we can weaken the virus.
It can replicate to some level, but then loses the battle to the host RNAi response,” Ding said.
“A virus weakened in this way can be used as a vaccine for boosting our RNAi immune system.”
When the researchers tested this strategy with a mouse virus called Nodamura, they did it with mutant mice lacking T and B cells.
With one vaccine injection, they found the mice were protected from a lethal dose of the unmodified virus for at least 90 days.
Note that some studies show nine mouse days are roughly equivalent to one human year.
There are few vaccines suitable for use in babies younger than six months old.
However, even newborn mice produce small RNAi molecules, which is why the vaccine protected them as well.
UC Riverside has now been issued a US patent on this RNAi vaccine technology
https://scitechdaily.com/no-more-endless-boosters-scientists-develop-one-for-all-virus-vaccine/
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Bees, like all other organisms, have a lot of parasites. And it is likely that these are the main contributors to issues like colony collapse disorder (CCD).
UT Austin scientists have targeted one such deadly fungal parasite, Nosema ceranae, and have genetically modified a bacteria commonly found in bee guts to produce an RNA interference system preventing the fungus from making spores.
#Bees #Bacteria #Fungi #Biology #Biotech #Biotechnology #RNAi #Science #Scicomm
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As part of our 20th anniversary, @Psarkies looks back at a classic #PLOSBiology paper that provided an early glimpse of the complexity of #RNAi pathways in #plants and how it acted as a springboard for further exploration of this extravagant universe https://plos.io/3DZgvps
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Mosquitoes and the disease they spread are a concern worldwide, especially in regards to invasive species that bring diseases less common in a region and those species that focus on biting humans.
A consortium of European researchers have come together to target the asian tiger mosquito by using RNA interference and food sources that the larva will take up, preventing their reproduction.
#Mosquito #RNA #RNAi #Europe #Science #Biotech #Biotechnology #Biology #Scicomm
https://www.sciencedirect.com/science/article/pii/S0734975023000745?via%3Dihub
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Repeated cycles of #SexChromosome conflict in #Drosophila simulans, involving X-linked protamine-derived loci & their autosomal #RNAi suppressors, drive #genome evolution, remodel #gametogenesis & may mediate reproductive isolation @lucksmith #PLOSBiology https://plos.io/43NIa7N
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New on Entomology Today: A study evaluating one of the first insecticides developed to use RNA interference as a mode of action finds significant effects on mobility, pupation, and reproduction of the target insect, the Colorado potato beetle. #entomology #insects #IPM #RNAi https://entomologytoday.org/2023/04/06/rna-interference-biopesticide-ledprona-colorado-potato-beetle/
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Eleven Therapeutics (Cambridge, UK) is looking for a molecular biologist. PhD, with experience in #RNA, #DNA, mammalian, #NGS, high-throughput.
I am not connected to this company, but i've been engaging with Yaniv Erlich, the founder/CEO, on the twitter for several years now and he has awesome ideas.
They already published cool paper on #RNAi therapy for #COVID.
So, if you're interested, i reccomend.https://docs.google.com/document/d/1EcnmbrHvFlJvEw8hE0jgskci93MQMHN2Vo1A0_RmwQE/edit?usp=drivesdk
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Electron transport chain RNAi in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster
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🧬🥔🛡️⚔️🐞🎆
Xu et al. illustrate the powerful potential of PM-RNAi
to control #Coccinellidae pests (like the 28-spotted #potato ladybird) in solanaceous crops.
https://doi.org/10.1111/jipb.13411
@wileyplantsci
#JIPB #PlantScience #phytopathology #CropScience #agriculture #RNAi -
great seminar by @[email protected] yesterday for our DB dept talk @[email protected], delivering the gospel of #meioticdrive with a new metaphor. you may have seen his faculty application in your pile, snap him up before someone else does! #genomeconflict #speciation #RNAi
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Este meme sale en mi próximo artículo/charla sobre microARN. XDDD #xp
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RT @DNA_RNA_Uni
I laughed so hard 😆😅😚#RNAi #siRNA #miRNA #featuredpaper https://mdpi.com/1422-0067/23/23/14755
https://twitter.com/DNA_RNA_Uni/status/1597927406136086528 -
Love this story: the crazy RNA pUG tails Scott Kennedy previously showed target RNAs for heritable silencing in worms turn out to make a crazy beautiful structure that recruits RdRP:
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Our discovery of mutations in the CIDEB gene that protect against liver disease is published in @NEJM, leading to possible #RNAi therapeutics for NASH by Regeneron & Alnylam.
Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2117872. Press release: https://investor.regeneron.com/news-releases/news-release-details/regeneron-genetics-center-discovers-rare-mutations-cideb-gene “That could enter clinical stages of development in the next year”. For anyone still doubting the usefulness of gwas. -
Right, having moved servers: #Drosophila #Virus #Evolution #PopGen #Phylogeny #Genome #Insect #RNAi #Metagenomics #Fly #Preprint