Today is the last day to register for the UK Membrane Traffic Meeting (organised by Chris Stefan and Jez Carlton in London).
#membranetraffic — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #membranetraffic, aggregated by home.social.
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The “full collapse vs kiss-and-run” debate for synaptic vesicle fusion dates back to the 1970s. In the last 10 years ultrafast endocytosis was proposed as a reconciliation. A paper out in Science today describes “Kiss-shrink-run” and hyperfast recycling…
Their observation of vesicles that shrink upon exocytosis is cool and the technology that enabled this cryoET is very impressive. As for resolving any debate - let's see.
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^ if this paper is of interest. There's a related preprint from van der Groot, Dal Peraro and D’Angelo labs:
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This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport.
The mechanistic basis of cargo selection during Golgi maturation
Taylor, Zubkov, Ciazynska et al.
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Gabrielle is giving a talk today in the Warwick SLS-WMS Postdoc Association Seminar Series.
"Hacking the logic of clathrin-coated vesicle creation”
10 am in A1.51, Gibbet Hill
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A riddle for Golgi Day: how many Golgis can you spot in this photo? #membranetraffic #CellBiology
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I’m currently looking for a post-doc in the UK, particularly to work on projects that employ in-vitro reconstitution and quantitative #microscopy approaches to study #cellbiology processes (esspecially #membranetraffic) + would be grateful for sign-posting towards openings! 🙏 #academicchatter
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We received this payment card protector to incentivise us to take part in an Office for National Statistics Crime survey.
I said, ‘ah they’ve used the classic Biorender concentric-ring endoplasmic reticulum icon as their logo.’
My partner responded, ‘I think that’s meant to be a finger print because it talks about protecting your identity.’
Only the real ones would understand… #CellBiology #membranetraffic -
EMBO Workshop
From molecules to organisms: An integrative view of cell biology
16 – 21 March 2025 | Radstadt, AustriaOrganised by Sharon Tooze and Marino Zerial
Deadline is 1st Dec
https://meetings.embo.org/event/25-cell-bio -
And now for some new News!
This week we welcomed Anneline Moret to our lab. Anneline is a EUTOPIA co-tutelle student between our lab and Paris Cergy University. She'll be working on engineered membrane traffic of integrin in a cancer context.
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In September, Mary's paper on ATG9A-flavour INVs was posted on bioRxiv.
ATG9 vesicles are a subtype of intracellular nanovesicle
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This was a highlight from the UK Membrane Traffic meeting last year. Looks like there is some new analysis in here compared to the preprint.
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
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As I’m writing an overview of membrane trafficking mechanisms for my PhD thesis introduction, I’m remembering Prof David Stephens (1971-2024) and Dr Ian Moore (1964-2018) and how they shaped my thinking and nurtured my enthusiasm through conversations that have stuck with me for many years or comprehensive and captivatingly written reviews. I’m sure countless other scientists can say the same. Both were gone too soon, but their legacy will continue to inspire us #CellBiology #MembraneTraffic
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As I ponder the molecular anatomy of the trafficking organelles I’ve been working on during my PhD in the final stretch of my thesis writing, I remain in awe of this tour-de-force of a paper that tackled this question nearly 20 years ago. Takamori et al., Cell (2006): https://www.cell.com/cell/fulltext/S0092-8674(06)01400-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867406014000%3Fshowall%3Dtrue
The v-ATPases visibly poking out of the vesicle membranes in their electron tomograms look so cute - they’re my all-time favourite proteins!
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This is an interesting paper from Min Lui and Alan Jian Zhu about EHPB1 inhibiting the clathrin adaptor protein1 (AP1) to ensure wingless is delivered to both the apical and basolateral surfaces.
https://www.embopress.org/doi/full/10.1038/s44319-024-00289-1
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Deeply saddened by the news that my friend David Stephens died last night.
David was an outstanding cell biologist based at Bristol whose work spanned #MembraneTraffic #cytoskeleton #ciliogenesis and more. He was “one of the good guys”. Kind, supportive, generous with his time, and rigorous about his science. I’ll miss him.
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Gabrielle is giving today's @Warwick_CMCB talk at 13.05 in T0.08/09
“Hacking the logic of clathrin-coated vesicle formation”
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UK #MembraneTraffic people: this year's meeting is organised by Jez Carlton and Chris Stefan. It'll be at KCL (Guy's) 16th Dec.
There's a call for talks and sign up. If you're interested but not on the email list, HMU. -
Just a note of appreciation for this review of phosphoinositide signalling in membrane trafficking from Volker Haucke’s lab: https://www.nature.com/articles/s41580-022-00490-x
It’s so comprehensive + the graphics are beautiful. I’ve regularly referred to it over the last couple of years to find the primary literature references I was after and every time I open the PDF I still go, ‘wow, that’s amazing!’ #CellBiology #membranetraffic #thesiswriting #PhDlife -
Hooray for #MembraneTraffic #CellBiology
Scott Emr and Wesley Sundquist Awarded 2024 Horwitz Prize for Discovering the ESCRT Pathway
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Seeing these vesicles zooming around the cell + then darting over to the mitochondria within seconds after you add the drug to trap them there never gets old 🔬🤩 #CellBiology #microscopy #membranetraffic #BiologyIsBeautiful
From: @steveroyle
https://biologists.social/@steveroyle/113125154969359577 -
We have a new preprint out!
It's about the molecularly diverse world of Intracellular Nanovesicles (INVs).ATG9 vesicles are a subtype of intracellular nanovesicle
https://www.biorxiv.org/content/10.1101/2024.09.12.612637v1@MAFesenko @Moore_cell Peyton Ewbank
@roylelab @Warwick_CMCB -
I was in Cambridge yesterday to do a PhD viva of Jessica Eden, the first PhD from the lab of David Gershlick at CIMR. For anyone interested, her main thesis paper is up on bioRxiv investigating RABGAP1 in trafficking and processing of APP (amyloid precursor protein).
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In today’s dispatches from the ‘scope I bring you very hungry HeLa cells with giant autophagosomes labelled with an antibody for the canonical autophagosome marker LC3. Most other cells in my samples have much smaller autophagosomes so these ones are outliers I won’t be including in further analysis. I thought I’d just leave them here! I wonder what was getting degraded inside those autophagosomes when I fixed those cell 🤔 #CellBiology #microscopy #membranetraffic
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What's the best format for a research community to share information and resources?
I recently attended a GRC and one of the attendees wanted to start a LinkedIn group for our field so we can more easily communicate with one another about upcoming events, publications, or discoveries of bad reagents.
The only examples I have of this are e-mail feeds like the pombe listserv.
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This project, spearheaded by @sahilkamboj in collaboration with Ambroise Lambert and co. at CY Cergy Paris University, has been lots of fun. We show that a5b1 integrins can be removed from the cell surface by triggered endocytosis, and then look at the consequences for cell-cell interactions.
#cellbiology #microscopy #MembraneTraffic #bioengeneering https://biologists.social/@biorxivpreprint/112689130956517175 -
Hey #membranetraffic ppl. Wanna learn about the most important protein family that you’ve probably never heard of?
I’m giving a talk at membrane traffic online this Thursday 11am est on the heatr5 family of proteins.
Thanks to Felix Fran and Ishier for the invite!!
Info on getting a zoom link is here
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Wow look at Flotillin. What a beast! New preprint from Rod MacKinnon's group looking at Flotillins in situ by cryoEM
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Comment by Rob Parton, Justin Taraska and Richard Lundmark on whether endocytosis by caveolae is dynamin-dependent. There are now several lines of evidence to suggest that it is not.
The 1990s evidence for dynamin scission was largely circumstantial and driven by an assumption that caveolae were analogous to clathrin-coated pits. Re-evaluating these ideas 25+ years later with modern techniques is long overdue. -
I had a fun day hanging out with Chris MacDonald, yeast membrane traffic wizard, who visited Warwick today. His group are doing really cool imaging combined with the power of yeast genetics. #MembraneTraffic
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Fantastic to see @David_Stephens recognised by the Royal Microscopy Society with a Scientific Achievement Award. Spanning #MembraneTraffic #cytoskeleton and #cilia, work from his lab is always high quality. He's an inspirational scientist as the linked citation spells out.
I've tagged him here although I'm sure he has better things to do than read Mastodon these days :)
https://www.rms.org.uk/resource/professor-david-stephens-receives-rms-scientific-achievement-award.html -
I had a fun morning in the microscope room (a.k.a. the disco) trying to get photostimulation working. Spent a lot of time being dazzled by vesicles 🤩
#cellbiology #MembraneTraffic #microscopy -
@MarkFrankBio “Macroautophagy (hereafter referred to as autophagy)”
https://pubmed.ncbi.nlm.nih.gov/?term=macroautophagy+AND+hereafter
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Chris Stefan and Dan Cutler are running the UK #MembraneTrafficking Meeting at UCL on 18th Dec.
Register (£25) by 8th Dec
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I enjoyed this Perspective article on the role of membranes as surfaces to organise cellular activities.
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This preprint from Groza et al. (Helge Ewers lab) looks really interesting. Exploring how particles (such as virions) gain entry to cells. Really neat application of synthetic tools to show that overcoming energy for membrane deformation is the key step to endocytosis.
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#Introduction (just moved to new instance)
I am a cell biologist running a research group (@roylelab) focused on membrane traffic and cell division in human cells. My lab is in @Warwick_CMCB at #WarwickUni. My posts are mainly about #science and #CellBiology but also #music, #running and #cycling.
#Microscopy #ImageAnalysis #MembraneTraffic #Mitosis #OpenScience #RStats
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I really like the idea of microPublications. This one is an intriguing observation:
https://www.micropublication.org/journals/biology/micropub-biology-000737
I’m sure many labs have some interesting results tucked away that suit this format.
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Enjoyable day here at Instituto Gulbenkian de Ciência serving on the PhD jury for Margarida Araújo (Telley + Oliveira labs) who passed with flying colours. Fun project looking at the role of ER in mitotic spindle function in drosophila. You can read her work here:
https://www.life-science-alliance.org/content/6/1/e202201540
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My lab has a #vacancy for a #PostDoc working on a #MembraneTraffic project. It will be of interest to #microscopy people with an interest in neuronal cell biology. Closing 12th Feb.
Boosts appreciated! -
And so to Mastodon. Exploring use here for #science #research #academia #sciencepolicy #cellbiology #cilia #membranetraffic #membranetraffcking (needs a unified tag!)
Starting again seems good.
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I am slightly biased but Méghane just gave a fantastic talk here on vesicle movement in cells #CellBiology #MembraneTraffic