#smallfiberneuropathy — Public Fediverse posts

@AskPippa

"Genipin is being studied as a potential treatment for a rare degenerative nervous system disorder that is caused by a gene mutation. The condition is known as familial dysautonomia, which becomes evident during infancy. The hypothesis of this relatively large cadre of regenerative medicine researchers is that genipin from the humble gardenia plant—known scientifically as Gardenia jasminoides—possesses the secret to effective treatment."

~

I wonder if genipin could be used for small fiber neuropathy?

~

This genipin stuff looks like it might have helped my father, who had multiple system atrophy and peripheral neuropathy (which I think may have been small fiber neuropathy) -

Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage
https://www.nature.com/articles/s41467-023-37561-2

#genipin #NaturalProducts #dysautonomia #SmallFiberNeuropathy
#neuroscience

Association Between NK Cell Genetic Variants and the Development of #LongCOVID Associated- & Prepandemic #SmallFiberNeuropathy

https://onlinelibrary.wiley.com/doi/10.1002/jmv.70091

"we show that patients with #SFN unrelated to #SARSCoV2 infection exhibited markers of impaired NKG2C functions significantly more frequently than healthy controls, while this was not observed for patients with LC‐associated signs of smallfiber dysfunction, including patients with confirmed LC‐SFN”

@longcovid #pwlc #pasc

#SmallFiberNeuropathy after #COVID19: A Key to #LongCOVID

https://www.medrxiv.org/content/10.1101/2023.11.07.23297764v1

"92% of [the #PostCovid] patients reported post-exertional malaise characteristic of ME/ #CFS and six patients underwent invasive cardiopulmonary exercise testing (iCPET), which demonstrated neurovascular dysregulation & dysautonomia consistent with #mecfs "

"#SFN is responsive to treatment with #IVIG"

@longcovid
#PwLC #postcovid19 #LC #Covidlonghaulers @mecfs
#PwME @covid19 #Coronavirus
#COVIDー19 #COVID

New interesting paper from Spain

Dysautonomia and small fiber neuropathy in #postCOVID condition and #ChronicFatigueSyndrome*

Free full text:
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04678-3

*Fukuda
#SmallFiberNeuropathy #SFN #Dysautonomia @mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #MyalgicE #POTS [email protected] @dysautonomia @longcovid
#LongCovid #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

I painted my nails! I sparkle once more. (Colors are I'm Over Brew and Frost Light by Holo Taco.)

*happy dance*

The husband is off work tomorrow and Monday, so let's get this jolly holiday going!

Starting with some Critical Role in a half hour.

My life rocks.

#unironicHashtagBlessed #CriticalRole #happy #disabled #backOnMyMeds #adhd #SmallFiberNeuropathy #GrannysGotArthritis #HoloTaco #nailPolish #iSparkle

Made 3 red-tape phone calls today because the pharmacy still can't fill my ADHD meds. I discovered that at least 3 of my medications require prior authorization before the new insurance company will fill them and another med just flat out isn't covered. (WTF? It's not a controlled substance or kryptonite or some shit, it's for goddamn GERD.)

And--AND!--I showered. Not just a quickie, either. Full service complete with leg shaving.

WITNESS ME

Now, of course, my spoons are depleted and I still don't have my meds, but check it out, I did stuff.

(Why yes, I am in between projects at work at the moment, why do you ask? 🙃 )

#disabled #spoonie #adhd #SmallFiberNeuropathy #HandPain #dysautonomia